164 research outputs found
Compact Representation of Photosynthesis Dynamics by Rule-based Models (Full Version)
Traditional mathematical models of photosynthesis are based on mass action
kinetics of light reactions. This approach requires the modeller to enumerate
all the possible state combinations of the modelled chemical species. This
leads to combinatorial explosion in the number of reactions although the
structure of the model could be expressed more compactly. We explore the use of
rule-based modelling, in particular, a simplified variant of Kappa, to
compactly capture and automatically reduce existing mathematical models of
photosynthesis. Finally, the reduction procedure is implemented in BioNetGen
language and demonstrated on several ODE models of photosynthesis processes.
This is an extended version of the paper published in proceedings of 5th
International Workshop on Static Analysis and Systems Biology (SASB) 2014.Comment: SASB 2014 full pape
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Debugging real accelerators
Particle losses and emittance growth in the injection process can result form mismatched injected beams arising from quadrupole errors in the ring and injection line. We describe a method, based on carefully analyzing the BPM-corrector response matrix, which allows the accurate determination of quadrupole errors and, at the same time, determines BPM and corrector calibration errors as well as the BPM resolution. Results from SPEAR, NSLS, ALS, and CELSIUS will be briefly described
The making of nickel and nickel-alloy shapes by casting, powder metallurgy, electroforming, chemical vapor deposition, and metal spraying
Casting, powder metallurgy, electroforming, metal spraying, and chemical vapor deposition techniques for producing nickel and nickel-alloy shape
Prevalence of non-O157:H7 shiga toxin-producing Escherichia coli in diarrheal stool samples from Nebraska.
We determined the prevalence of Shiga toxin-producing Escherichia coli (STEC) in diarrheal stool samples from Nebraska by three methods: cefixime-tellurite sorbitol MacConkey (CT- SMAC) culture, enterohemorrhagic E. coli (EHEC) enzyme immunoassay, and stx1,2 polymerase chain reaction (PCR). Fourteen (4.2%) of 335 specimens were positive by at least one method (CT-SMAC culture [6 of 14], EHEC enzyme immunoassay [13 of 14], stx1,2 PCR [14 of 14]). Six contained serogroup O157, while non-O157 were as prevalent as O157 serogroups
Regional investigation of a cyclosporiasis outbreak linked to imported romaine lettuce – Nebraska and Iowa, June–August 2013
A regional, multistate investigation into a June–August 2013 cyclosporiasis outbreak was conducted in Nebraska, Iowa, and neighbouring states. Cases were confirmed on the basis of laboratory and clinical findings. Of 227 cases in Iowa (n = 140) and Nebraska (n=87) residents, 162 (71%) reported dining at chain A/B restaurants – 96% reported house salad consumption. A case-control study identified chain A/B house salad as the most likely vehicle. Traceback was conducted to ascertain production lot codes of bagged salad mix (iceberg and romaine lettuce, red cabbage, and carrots) served as house salad in implicated restaurants. A single production lot code of salad mix supplied by both a common producer and distributor was linked to the majority of confirmed cases in persons reporting regional chain A/B exposure. The salad mix linked to illnesses contained imported romaine lettuce from two separate single-grower fields-of-origin and 51 additional field from another grower
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Coupling Correction and Beam Dynamics at Ultralow Vertical Emittance in the ALS
For synchrotron light sources and for damping rings of linear colliders it is important to be able to minimize the vertical emittance and to correct the spurious vertical dispersion. This allows one to maximize the brightness and/or the luminosity. A commonly used tool to measure the skew error distribution is the analysis of orbit response matrices using codes like LOCO. Using the new Matlab version of LOCO and 18 newly installed power supplies for individual skew quadrupoles at the ALS the emittance ratio could be reduced below 0.1% at 1.9 GeV yielding a vertical emittance of about 5 pm. At those very low emittances, additional effects like intra beam scattering become more important, potentially limiting the minimum emittance for machine like the damping rings of linear colliders
Ceftriaxone-Resistant Salmonella Infection Acquired by a Child from Cattle
Background The emergence of resistance to antimicrobial agents within the salmonellae is a worldwide problem that has been associated with the use of antibiotics in livestock. Resistance to ceftriaxone and the fluoroquinolones, which are used to treat invasive salmonella infections, is rare in the United States. We analyzed the molecular characteristics of a ceftriaxone-resistant strain of Salmonella enterica serotype typhimurium isolated from a 12-year-old boy with fever, abdominal pain, and diarrhea. Methods We used pulsed-field gel electrophoresis and analysis of plasmids and β-lactamases to compare the ceftriaxone-resistant S. enterica serotype typhimurium from the child with four isolates of this strain obtained from cattle during a local outbreak of salmonellosis. Results The ceftriaxone-resistant isolate from the child was indistinguishable from one of the isolates from cattle, which was also resistant to ceftriaxone. Both ceftriaxone-resistant isolates were resistant to 13 antimicrobial agents; all but one of the resistance determinants were on a conjugative plasmid of 160 kb that encoded the functional group 1 β-lactamase CMY-2. Both ceftriaxone-resistant isolates were closely related to the three other salmonella isolates obtained from cattle, all of which were susceptible to ceftriaxone. Conclusions This study provides additional evidence that antibiotic-resistant strains of salmonella in the United States evolve primarily in livestock. Resistance to ceftriaxone, the drug of choice for invasive salmonella disease, is a public health concern, especially with respect to children, since fluoroquinolones, which can also be used to treat this disease, are not approved for use in children
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