Nietypowy przypadek złamania prowadnika podczas pierwotnej przezskórnej angioplastyki wieńcowej - obserwacja dwuletnia

We report a case of inferior myocardial infarction treated with primary percutaneous coronary intervention. During the procedure, the guide wire fractured within the right coronary artery. Despite many attempts, the piece of wire could not be removed. The options were to take the fractured wire out (either percutaneously or surgically) or to leave it in the patient. After discussion with cardiac surgeons, we managed the patient medically. The motto of this case report is that, although percutaneous and surgical management may be the primary options, medical management with dual antiplatelet drugs is possible. Kardiol Pol 2010; 68, 11: 1291-129

Evaluation of therelationship between epicardial adipose tissue and myocardial performance (Tei) index

WOS: 000341255900015PubMed: 25035785Aim: Epicardial adipose tissue (EAT) is a tissue around the heart with visceral adipose properties. It can affect the structure and functions of the myocardium and coronary arteries through inflammatory markers and regulators. The myocardial performance (Tei) index is a parameter capable of globally assessing systolic and diastolic heart functions. This study investigated the relation between EAT thickness and the Tei index. Methods: The study population was selected from patients without structural heart disease. EAT thickness was measured with two-dimensional imaging in parasternal long axis view and from the anterior face of the right ventricle. Tei index measurement was calculated with tissue Doppler echocardiography from the mitral lateral annulus. The relation between the Tei index and EAT was assessed using multivariate linear regression analysis. Results: Forty-three patients (36 female, 7 male; mean age 50.2 +/- 10.6 years) were included in the study. Mean Tei index was 0.39 +/- 0.09, and mean EAT thickness 4.7 +/- 2.4 mm. A significant correlation was determined between tissue Doppler Tei index and EAT thickness at correlation analysis (r = 0.522, P < 0.001). EAT thickness was independently correlated with Tei index at multivariate linear regression analysis (Beta = 0.443, t = 3.522, P = 0.001). Conclusion: EAT thickness is independently correlation with Tei index. Increased EAT thickness may therefore be a predictor of left ventricular dysfunction

Effects of α-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in sub-chronic thinner-addicted rats

Abstract: The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant− antioxidant balance, the relation between toxicity and oxidative stress, and a possible protective effect of α-lipoic acid against thinner toxication in rats. Sprague−Dawley rats were divided into 5 groups as follows: control (K), olive oil (Z), α-lipoic acid (L), thinner (T), and α-lipoic acid + thinner (LAT). Each group was composed of 15 rats, and the study lasted 8 weeks. After completing the animal studies malondialdehyde (MDA), reduced glutathione (GSH), methemoglobin (MetHb), toluol, and mononuclear leucocyte damage levels; protein oxidation, nitric oxide (NOx) metabolites, total antioxidant capacity (TAC), glucose, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were determined from blood specimens of the rats. The data obtained from the study were statistically analyzed using SPSS, and both ANOVA and Duncan tests were performed. P < 0.05 was accepted as statistically significant. The results indicated that α-lipoic acid has a protective and balancing effect against complications derived from thinner inhalation in rats.TÜBİTAK, project no.: 107T61

The effect of sleep disorders on quality of life in patients with epilepsy: A multicenter study from Turkey

Objective: We aimed to investigate sleep disorders in patients with epilepsy (PWE) and to investigate the effects of sleep disorders on quality of life. Methods: In our multicenter study conducted in Turkey, 1358 PWE were evaluated. The demographic and clinical data of the patients were recorded. The Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and Quality of Life in Epilepsy Inventory-10 (QOLIE-10) were administered. Results: The mean age of 1358 patients was 35.92 ± 14.11 (range, 18–89) years. Seven hundred fifty-one (55.30 %) were women. Some 12.7 % of the patients had insomnia (ISI > 14), 9.6 % had excessive daytime sleepiness (ESS > 10), 46.5 % had poor sleep quality (PSQI > 5), and 354 patients (26.1 %) had depressive symptoms (BDI > 16). The mean QOLIE-10 score was 22.82 ± 8.14 (10–48). Resistant epilepsy was evaluated as the parameter with the highest risk affecting quality of life Adjusted odds ratio (AOR = 3.714; 95 % confidence interval (CI): [2.440–5.652] < 0.001)). ISI (AOR = 1.184; 95 % CI: [1.128–1.243]; p < 0.001), ESS (AOR = 1.081; 95 % CI: [1.034–1.130]; p < 0.001), PSQI (AOR = 0.928; 95 % CI: [0.867 – 0.994]; p = 0.034), BDI (AOR = 1.106; 95 % CI: [1.084–1.129]; p < 0.001), epilepsy duration (AOR = 1.023; 95 % CI: [1.004–1.041]; p = 0.014), were determined as factors affecting quality of life. Significance: Sleep disorders are common in PWE and impair their quality of life. Quality of life can be improved by controlling the factors that may cause sleep disorders such as good seizure control, avoiding polypharmacy, and correcting the underlying mood disorders in patients with epilepsy