A dust scattered halo in starburst galaxy M82?

The source of the halo about M82 has been under discussion for several years. One explanation for it is the dust model of Solinger, Morrison and Markert in which they propose a diffuse cloud of dust through the M81 group, with M82 traveling through the group holding a denser cloud of dust around it. The feasibility of the dust theory is examined in the X-ray range, using the halo in the X-ray image of M82 taken by the Einstein Observatory. To this end the X-ray cross section for dust is presented, along with the single scattered image of an X-ray source surrounded by a dust cloud; multiply scattered images were simulated with a Monte Carlo program; profiles of the halo along the major and minor axes of M82 are presented. Also presented is an accounting for line spectrographs of M82 that show unusual splitting, using the dust model. The final model proposed for the X-ray image requires dust of radius 50 to 300 A, with density on the order of 10 to the -7th power cu cm, out to a distance of about 9 kpc for some regions

Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome

Wolfram syndrome (WS) is a recessive multisystem disorder defined by the association of diabetes mellitus and optic atrophy, reminiscent of mitochondrial diseases. The role played by mitochondria remains elusive, with contradictory results on the occurrence of mitochondrial dysfunction. We evaluated 13 recessive WS patients by deep clinical phenotyping, including optical coherence tomography (OCT), serum lactic acid at rest and after standardized exercise, brain Magnetic Resonance Imaging, and brain and muscle Magnetic Resonance Spectroscopy (MRS). Finally, we investigated mitochondrial bioenergetics, network morphology, and calcium handling in patient-derived fibroblasts. Our results do not support a primary mitochondrial dysfunction in WS patients, as suggested by MRS studies, OCT pattern of retinal nerve fiber layer loss, and, in fibroblasts, by mitochondrial bioenergetics and network morphology results. However, we clearly found calcium mishandling between endoplasmic reticulum (ER) and mitochondria, which, under specific metabolic conditions of increased energy requirements and in selected tissue or cell types, may turn into a secondary mitochondrial dysfunction. Critically, we showed that Wolframin (WFS1) protein is enriched at mitochondrial-associated ER membranes and that in patient-derived fibroblasts WFS1 protein is completely absent. These findings support a loss-of-function pathogenic mechanism for missense mutations in WFS1, ultimately leading to defective calcium influx within mitochondria

Refining the prediction for OJ 287 next impact flare arrival epoch

The bright blazar OJ~287 routinely parades high brightness bremsstrahlung flares which are explained as being a result of a secondary supermassive black hole (SMBH) impacting the accretion disk of a primary SMBH in a binary system. We begin by showing that these flares occur at times predicted by a simple analytical formula, based on the Kepler equation, which explains flares since 1888. The next impact flare, namely the flare number 26, is rather peculiar as it breaks the typical pattern of two impact flares per 12 year cycle. This will be the third bremsstrahlung flare of the current cycle that follows the already observed 2015 and 2019 impact flares from OJ~287. Unfortunately, astrophysical considerations make it difficult to predict the exact arrival epoch of the flare number 26. In the second part of the paper, we describe our recent OJ~287 observations. They show that the pre-flare light curve of flare number 22, observed in 2005, exhibits similar activity as the pre-flare light curve in 2022, preceding the expected flare number 26 in our model. We argue that the pre-flare activity most likely arises in the primary jet whose activity is modulated by the transit of the secondary SMBH through the accretion disk of the primary. Observing the next impact flare of OJ~287 in October 2022 will substantiate the theory of disk impacts in binary black hole systems.Comment: 16 pages, 2 figure

Refining the 2022 OJ 287 impact flare arrival epoch

The bright blazar OJ~287 routinely parades high brightness bremsstrahlung flares, which are explained as being a result of a secondary supermassive black hole (SMBH) impacting the accretion disc of a more massive primary SMBH in a binary system. The accretion disc is not rigid but rather bends in a calculable way due to the tidal influence of the secondary. Below we refer to this phenomenon as a variable disc level. We begin by showing that these flares occur at times predicted by a simple analytical formula, based on general relativity inspired modified Kepler equation, which explains impact flares since 1888. The 2022 impact flare, namely flare number 26, is rather peculiar as it breaks the typical pattern of two impact flares per 12-year cycle. This is the third bremsstrahlung flare of the current cycle that follows the already observed 2015 and 2019 impact flares from OJ~287. It turns out that the arrival epoch of flare number 26 is sensitive to the level of primary SMBH's accretion disc relative to its mean level in our model. We incorporate these tidally induced changes in the level of the accretion disc to infer that the thermal flare should have occurred during July-August 2022, when it was not possible to observe it from the Earth. Thereafter, we explore possible observational evidence for certain pre-flare activity by employing spectral and polarimetric data from our campaigns in 2004/05 and 2021/22. We point out theoretical and observational implications of two observed mini-flares during January-February 2022.Comment: 29 pages, 6 figures, 1 table. arXiv admin note: text overlap with arXiv:2209.0836

On the need of an ultramassive black hole in OJ 287

The highly variable blazar OJ~287 is commonly discussed as an example of a binary black hole system. The 130 year long optical light curve is well explained by a model where the central body is a massive black hole of 18.35$\times$10$^9$ solar mass that supports a thin accretion disc. The secondary black hole of 0.15$\times$10$^9$ solar mass impacts the disc twice during its 12 year orbit, and causes observable flares. Recently, it has been argued that an accretion disc with a typical AGN accretion rate and above mentioned central body mass should be at least six magnitudes brighter than OJ~287's host galaxy and would therefore be observationally excluded. Based on the observations of OJ~287's radio jet, detailed in Marscher and Jorstad (2011), and up-to-date accretion disc models of Azadi et al. (2022), we show that the V-band magnitude of the accretion disc is unlikely to exceed the host galaxy brightness by more than one magnitude, and could well be fainter than the host. This is because accretion power is necessary to launch the jet as well as to create electromagnetic radiation, distributed across many wavelengths, and not concentrated especially on the optical V-band. Further, we note that the claimed V-band concentration of accretion power leads to serious problems while interpreting observations of other Active Galactic Nuclei. Therefore, we infer that the mass of the primary black hole and its accretion rate do not need to be smaller than what is determined in the standard model for OJ~287

Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy

Leber's hereditary optic neuropathy (LHON), a disease associated with a mitochondrial DNA mutation, is characterized by blindness due to degeneration of retinal ganglion cells (RGCs) and their axons, which form the optic nerve. We show that a sustained pathological autophagy and compartment-specific mitophagy activity affects LHON patient-derived cells and cybrids, as well as induced pluripotent-stem-cell-derived neurons. This is variably counterbalanced by compensatory mitobiogenesis. The aberrant quality control disrupts mitochondrial homeostasis as reflected by defective bioenergetics and excessive reactive oxygen species production, a stress phenotype that ultimately challenges cell viability by increasing the rate of apoptosis. We counteract this pathological mechanism by using autophagy regulators (clozapine and chloroquine) and redox modulators (idebenone), as well as genetically activating mitochondrial biogenesis (PGC1-α overexpression). This study substantially advances our understanding of LHON pathophysiology, providing an integrated paradigm for pathogenesis of mitochondrial diseases and druggable targets for therapy

VERITAS discovery of very high energy gamma-ray emission from S3 1227+25 and multiwavelength observations

We report the detection of very high energy gamma-ray emission from the blazar S3 1227+25 (VER J1230+253) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS). VERITAS observations of the source were triggered by the detection of a hard-spectrum GeV flare on May 15, 2015 with the Fermi-Large Area Telescope (LAT). A combined five-hour VERITAS exposure on May 16th and May 18th resulted in a strong 13$\sigma$ detection with a differential photon spectral index, $\Gamma$ = 3.8 $\pm$ 0.4, and a flux level at 9% of the Crab Nebula above 120 GeV. This also triggered target of opportunity observations with Swift, optical photometry, polarimetry and radio measurements, also presented in this work, in addition to the VERITAS and Fermi-LAT data. A temporal analysis of the gamma-ray flux during this period finds evidence of a shortest variability timescale of $\tau_{obs}$ = 6.2 $\pm$ 0.9 hours, indicating emission from compact regions within the jet, and the combined gamma-ray spectrum shows no strong evidence of a spectral cut-off. An investigation into correlations between the multiwavelength observations found evidence of optical and gamma-ray correlations, suggesting a single-zone model of emission. Finally, the multiwavelength spectral energy distribution is well described by a simple one-zone leptonic synchrotron self-Compton radiation model.Comment: 18 pages, 6 figures. Accepted for publication in the Astrophysical Journal (ApJ

Observational Implications of OJ 287’s Predicted 2022 Disk Impact in the Black Hole Binary Model

We present a summary of the results of the OJ 287 observational campaign, which was carried out during the 2021/2022 observational season. This season is special in the binary model because the major axis of the precessing binary happens to lie almost exactly in the plane of the accretion disc of the primary. This leads to pairs of almost identical impacts between the secondary black hole and the accretion disk in 2005 and 2022. In 2005, a special flare called “blue flash” was observed 35 days after the disk impact, which should have also been verifiable in 2022. We did observe a similar flash and were able to obtain more details of its properties. We describe this in the framework of expanding cloud models. In addition, we were able to identify the flare arising exactly at the time of the disc crossing from its photo-polarimetric and gamma-ray properties. This is an important identification, as it directly confirms the orbit model. Moreover, we saw a huge flare that lasted only one day. We may understand this as the lighting up of the jet of the secondary black hole when its Roche lobe is suddenly flooded by the gas from the primary disk. Therefore, this may be the first time we directly observed the secondary black hole in the OJ 287 binary system

The 2009 december gamma-ray flare of 3C 454.3: The multifrequency campaign

During the month of 2009 December, the blazar 3C 454.3 became the brightest gamma-ray source in the sky, reaching a peak flux F 2000 × 10 -8 photons cm-2 s-1 for E > 100 MeV. Starting in 2009 November intensive multifrequency campaigns monitored the 3C 454 gamma-ray outburst. Here, we report on the results of a two-month campaign involving AGILE, INTEGRAL, Swift/XRT, Swift/BAT, and Rossi XTE for the high-energy observations and Swift/UVOT, KANATA, Goddard Robotic Telescope, and REM for the near-IR/optical/UV data. GASP/WEBT provided radio and additional optical data. We detected a long-term active emission phase lasting 1 month at all wavelengths: in the gamma-ray band, peak emission was reached on 2009 December 2-3. Remarkably, this gamma-ray super-flare was not accompanied by correspondingly intense emission in the optical/UV band that reached a level substantially lower than the previous observations in 2007-2008. The lack of strong simultaneous optical brightening during the super-flare and the determination of the broadband spectral evolution severely constrain the theoretical modeling. We find that the pre- and post-flare broadband behavior can be explained by a one-zone model involving synchrotron self-Compton plus external Compton emission from an accretion disk and a broad-line region. However, the spectra of the 2009 December 2-3 super-flare and of the secondary peak emission on 2009 December 9 cannot be satisfactorily modeled by a simple one-zone model. An additional particle component is most likely active during these states. © 2010. The American Astronomical Society. All rights reserved