Single versus multiple human-equivalent doses of C. parvum in mice: neutralization of the anti-metastatic effect.

The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated animals spleen weight peaked at 2 weeks and then fell. A single low dose caused a 3-fold increase, a single high dose or multiple low doses a 6-fold increase. Liver weight changes followed a similar pattern. Hepatosplenomegaly was prolonged by multiple doses. The effects of these treatments on Lewis tumour metastases were studied. A single high dose and a single low dose on the day of tumour implantation (Day 0) were equally effective at inhibiting pulmonary metastases. Repeated low doses starting on Day 0 were no more effective than a single dose. The effect of CP on survival after primary-tumour excision on Day 10 was observed. Low dose CP on Day 7 doubled the harmonic mean of survival time. Repeated doses were no more effective than a single dose. Low-dose prophylaxis up to 2 weeks before tumour significantly inhibited metastases. However, when repeated low-dose prophylaxis was combined with a single low dose on Day 0, the anti-metastatic effect was abrogated. This neutralization of the anti-metastatic effect of CP given on Day 0 was found to persist after a 13-week treatment-free interval. Possible mechanisms for this phenomenon are discussed

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine

The Fornax Spectroscopic Survey I. Survey Strategy and Preliminary Results on the Redshift Distribution of a Complete Sample of Stars and Galaxies

The Fornax Spectroscopic Survey will use the Two degree Field spectrograph (2dF) of the Anglo-Australian Telescope to obtain spectra for a complete sample of all 14000 objects with 16.5<=Bj<=19.7 in a 12 square degree area centred on the Fornax Cluster. By selecting all objects---both stars and galaxies---independent of morphology, we cover a much larger range of surface brightness and scale size than previous surveys. In this paper we present results from the first 2dF field. Redshift distributions and velocity structures are shown for all observed objects in the direction of Fornax, including Galactic stars, galaxies in and around the Fornax Cluster, and for the background galaxy population. The velocity data for the stars show the contributions from the different Galactic components, plus a small tail to high velocities. We find no galaxies in the foreground to the cluster in our 2dF field. The Fornax Cluster is clearly defined kinematically. The mean velocity from the 26 cluster members having reliable redshifts is 1560+/-80 km/s. They show a velocity dispersion of 380+/-50 km/s. Large-scale structure can be traced behind the cluster to a redshift beyond z=0.3. Background compact galaxies and low surface brightness galaxies are found to follow the general galaxy distribution.Comment: LaTeX format; uses aa.cls (included). Accepted for publication in Astronomy and Astrophysic

ATLBS Extended Source Sample: The evolution in radio source morphology with flux density

Based on the ATLBS survey we present a sample of extended radio sources and derive morphological properties of faint radio sources. 119 radio galaxies form the ATLBS-Extended Source Sample (ATLBS-ESS) consisting of all sources exceeding 30" in extent and integrated flux densities exceeding 1 mJy. We give structural details along with information on galaxy identifications and source classifications. The ATLBS-ESS, unlike samples with higher flux-density limits, has almost equal fractions of FR-I and FR-II radio galaxies with a large fraction of the FR-I population exhibiting 3C31-type structures. Significant asymmetry in lobe extents appears to be a common occurrence in the ATLBS-ESS FR-I sources compared to FR-II sources. We present a sample of 22 FR-Is at z>0.5 with good structural information. The detection of several giant radio sources, with size exceeding 0.7 Mpc, at z>1 suggests that giant radio sources are not less common at high redshifts. The ESS also includes a sample of 28 restarted radio galaxies. The relative abundance of dying and restarting sources is indicative of a model where radio sources undergo episodic activity in which an active phase is followed by a brief dying phase that terminates with restarting of the central activity; in any massive elliptical a few such activity cycles wherein adjacent events blend may constitute the lifetime of a radio source and such bursts of blended activity cycles may be repeated over the age of the host. The ATLBS-ESS includes a 2-Mpc giant radio galaxy with the lowest surface brightness lobes known to date.Comment: 69 pages, 119 figures, 4 tables, to appear in ApJ

The extragalactic radio-source population at 95 GHz

We have used the Australia Telescope Compact Array (ATCA) at 95GHz to carry out continuum observations of 130 extragalactic radio sources selected from the Australia Telescope 20GHz (AT20G) survey. Over 90% of these sources are detected at 95 GHz, and we use a triple-correlation method to measure simultaneous 20 and 95 GHz flux densities. We show that the ATCA can measure 95GHz flux densities to ~10% accuracy in a few minutes for sources above ~50mJy. The median 20-95GHz spectral index does not vary significantly with flux density for extragalactic sources with S20>150 mJy. This allows us to estimate the extragalactic radio source counts at 95GHz by combining our observed 20-95GHz spectral-index distribution with the accurate 20GHz source counts measured in the AT20G survey. The resulting 95GHz source counts down to 80 mJy are significantly lower than those found by several previous studies. The main reason is that most radio sources with flat or rising spectra in the frequency range 5-20GHz show a spectral turnover between 20 and 95 GHz. As a result, there are fewer 95GHz sources (by almost a factor of two at 0.1 Jy) than would be predicted on the basis of extrapolation from the source populations seen in lower-frequency surveys. We also derive the predicted confusion noise in CMB surveys at 95GHz and find a value 20-30% lower than previous estimates. The 95GHz source population at the flux levels probed by this study is dominated by QSOs with a median redshift z~1. We find a correlation between optical magnitude and 95GHz flux density which suggests that many of the brightest 95 GHz sources are relativistically beamed, with both the optical and millimetre continuum significantly brightened by Doppler boosting.Comment: Replaced with final version (MNRAS, in press), 15 pages plus two landscape data table

Preliminary archaeoentomological analyses of permafrost-preserved cultural layers from the pre-contact Yup’ik Eskimo site of Nunalleq, Alaska : implications, potential and methodological considerations

Acknowledgements Site excavation and samples collection were conducted by archaeologists from the University of Aberdeen, with the help of archaeologists and student excavators from the University of Aberdeen University of Alaska Fairbanks and Bryn Mawr College, Kuskokwim Campus, College of Rural Alaska and residents of Quinhagak and Mekoryuk. This study is funded through AHRC grant to the project ‘Understanding Cultural Resilience and Climate Change on the Bering Sea through Yup’ik Ecological Knowledge, Lifeways, Learning and Archaeology’ to Rick Knecht, Kate Britton and Charlotta Hillderal (University of Aberdeen; AH/K006029/1). Thanks are due to Qanirtuuq Inc. and Quinhagak, Alaska for sampling permissions and to entomologists working at the CNC in Ottawa for allowing access to reference collections of beetles, lice and fleas. Yves Bousquet, Ales Smetana and Anthony E. Davies are specially acknowledged for their help with the identification of coleopteran specimens. Finally, we would also like to thank Scott Elias for useful comments on the original manuscript.Peer reviewedPublisher PD

A Close Look at Star Formation around Active Galactic Nuclei

We analyse star formation in the nuclei of 9 Seyfert galaxies at spatial resolutions down to 0.085arcsec, corresponding to length scales of less than 10pc in some objects. Our data were taken mostly with the near infrared adaptive optics integral field spectrograph SINFONI. The stellar light profiles typically have size scales of a few tens of parsecs. In two cases there is unambiguous kinematic evidence for stellar disks on these scales. In the nuclear regions there appear to have been recent - but no longer active - starbursts in the last 10-300Myr. The stellar luminosity is less than a few percent of the AGN in the central 10pc, whereas on kiloparsec scales the luminosities are comparable. The surface stellar luminosity density follows a similar trend in all the objects, increasing steadily at smaller radii up to 10^{13}L_sun/kpc^2 in the central few parsecs, where the mass surface density exceeds 10^4M_sun/pc^2. The intense starbursts were probably Eddington limited and hence inevitably short-lived, implying that the starbursts occur in multiple short bursts. The data hint at a delay of 50--100Myr between the onset of star formation and subsequent fuelling of the black hole. We discuss whether this may be a consequence of the role that stellar ejecta could play in fuelling the black hole. While a significant mass is ejected by OB winds and supernovae, their high velocity means that very little of it can be accreted. On the other hand winds from AGB stars ultimately dominate the total mass loss, and they can also be accreted very efficiently because of their slow speeds.Comment: 51 pages, including 27 figures; accepted by ApJ (paper reorganised, but results & conclusions the same

Dusty Nuclear Disks and Filaments in Early Type Galaxies

We examine the dust properties of a nearby distance-limited sample of early type galaxies using the WFPC2 of the Hubble Space Telescope. Dust is detected in 29 out of 67 galaxies (43%), including 12 with small nuclear dusty disks. In a separate sample of 40 galaxies biased for the detection of dust by virtue of their detection in the IRAS 100 micron band, dust is found in ~78% of the galaxies, 15 of which contain dusty disks. In those galaxies with detectable dust, the apparent mass of the dust correlates with radio and far infrared luminosity, becoming more significant for systems with filamentary dust. A majority of IRAS and radio detections are also associated with dusty galaxies rather than dustless galaxies. This indicates that thermal emission from clumpy, filamentary dust is the main source of the far-IR radiation in early type galaxies. Dust in small disk-like morphology tends to be well aligned with the major axis of the host galaxies, while filamentary dust appears to be more randomly distributed with no preference for alignment with any major galactic structure. This suggests that, if the dusty disks and filaments have a common origin, the dust originates externally and requires time to dynamically relax and settle in the galaxy potential in the form of compact disks. More galaxies with visible dust than without dust display emission lines, indicative of ionized gas, although such nuclear activity does not show a preference for dusty disk over filamentary dust. There appears to be a weak relationship between the mass of the dusty disks and central velocity dispersion of the galaxy, suggesting a connection with a similar recently recognized relationship between the latter and the black hole mass.Comment: 17 pages, including 10 figures & 7 tables, to be published in the Astronomical Journa

Radio Sources in Low-Luminosity Active Galactic Nuclei. I. VLA Detections of Compact, Flat-Spectrum Cores

We report a 0.2" resolution, 15 GHz survey of a sample of 48 low-luminosity active galactic nuclei with the Very Large Array. Compact radio emission has been detected in 57% (17 of 30) of LINERs and low-luminosity Seyferts, at least 15 of which have a flat to inverted radio spectrum (alpha > -0.3). The compact radio cores are found in both type 1 (i.e. with broad Halpha) and type 2 (without broad Halpha) nuclei. The 2 cm radio power is significantly correlated with the emission-line ([OI] lambda6300) luminosity. While the present observations are consistent with the radio emission originating in star-forming regions, higher resolution radio observations of 10 of the detected sources, reported in a companion paper (Falcke et al. 2000), show that the cores are very compact (= 10^8K) and probably synchrotron self-absorbed, ruling out a starburst origin. Thus, our results suggest that at least 50% of low-luminosity Seyferts and LINERs in the sample are accretion powered, with the radio emission presumably coming from jets or advection-dominated accretion flows. We have detected only 1 of 18 `transition' (i.e. LINER + HII) nuclei observed, indicating their radio cores are significantly weaker than those of `pure' LINERs.Comment: To appear in the Astrophysical Journal, October 20, 200