Damar on Fridays

Abstract These poems are about the first hand witnessing of the Balkan war and its visceral repercussions, ripping of families across generations and continents due to religious intolerance, and an identity crisis within the diaspora of the former Yugoslav people. They interact with appeals of loss, in terms of bodies, memory, and material, despair within the identity of the self in and outside of religion, and the perception of love and belonging, but not necessarily in that order. They are largely inspired by victim story-telling, translations of conversations with natives of the former Yugoslavia and their children, and ramifications of searching for the self and a place to call home

Clinical epigenomics: Genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

PURPOSE: We describe the clinical implementation of genome-wide DNA methylation analysis in rare disorders across the EpiSign diagnostic laboratory network and the assessment of results and clinical impact in the first subjects tested. METHODS: We outline the logistics and data flow between an integrated network of clinical diagnostics laboratories in Europe, the United States, and Canada. We describe the clinical validation of EpiSign using 211 specimens and assess the test performance and diagnostic yield in the first 207 subjects tested involving two patient subgroups: the targeted cohort (subjects with previous ambiguous/inconclusive genetic findings including genetic variants of unknown clinical significance) and the screening cohort (subjects with clinical findings consistent with hereditary neurodevelopmental syndromes and no previous conclusive genetic findings). RESULTS: Among the 207 subjects tested, 57 (27.6%) were positive for a diagnostic episignature including 48/136 (35.3%) in the targeted cohort and 8/71 (11.3%) in the screening cohort, with 4/207 (1.9%) remaining inconclusive after EpiSign analysis. CONCLUSION: This study describes the implementation of diagnostic clinical genomic DNA methylation testing in patients with rare disorders. It provides strong evidence of clinical utility of EpiSign analysis, including the ability to provide conclusive findings in the majority of subjects tested

ON MAXIMAL FUNCTION AND V-CONJUGATION

In this paper we prove that on the 3-series field H1 cannot be defined by means of the V-conjugation. In other words, the norms kfkH1 and k ˜ fkL1 are not equivalent in the case of the 3-series field. This gives a new proof to the result of Memić [7], which answers a question raised by P. Simon [13]. Also, we prove that the mean value of function f ∈ L1(G) on the coset IN−1(x) is dominated by either MN−1 or MN on some translated element

Bihevioralnogenetičke osnove petofaktorskog modela ličnosti

Petofaktorski model ličnosti pretpostavlja da se osobine ličnosti mogu razumeti u terminima bazičnih pet domena: neuroticizma, ekstraverzije, otvorenosti ka iskustvu, prijatnosti i savesnosti. Pošto je razvoj ličnosti posledica složenih odnosa gena i sredine, osnovno teorijsko i istraživačko pitanje savremene bijevioralne genetike jeste na koji način geni i sredina oblikuju osobine. Osnovni ciljevi istraživanja bili su ispitivanje genskih i sredinskih faktora koji doprinose objašnjenju individualnih razlika na domenima i aspektima petofaktorskog modela ličnosti i veze između genotipova HTR1A, TPH2, BDNF, COMT, DRD2 i OXTR gena, njihovih epistatičkih efekata i dimenzija ličnosti petofaktorskog modela. U Studiji 1 učestvovala su 362 monozigotna i 210 dizigotna blizanaca iz Republike Srbije (M = 24,88; SD = 6,94). U Studiji 2 učestvovalo je 474 ispitanika iz Studije 1 (M = 24,48; SD = 7,58). Korišćeni instrumenti su revidirani NEO-PI-R inventar ličnosti (Costa & McCrae, 2019, adaptacija Knežević et al., 2004), zigotnost procenjena iz DNK bukalnog brisa i pojedinačni nukleotidni polimorfizmi HTR1A (rs6295), TPH2 (rs4570625), BDNF (rs6265), COMT (rs4680), DRD2 (rs1800497) i OXTR (rs53576) gena. Rezultati Studije 1 ukazuju na to da osobine ličnosti petofaktorskog modela pokazuju značajne aditivne genske i nedeljene sredinske doprinose, kao i da neki aspekti unutar domena imaju jake zajedničke osnove, dok su neki drugi gotovo nezavisni. Studija 2 sugeriše da serotoninski, dopaminski, oksitocin i moždani neurotrofni faktor sistemi gena leže u osnovi kompleksnih ponašanja, sa potencijalno različitim efektima na pojedinačne osobine ličnosti. Uloga dopaminskog genskom sistema najznačajnija je za domen ekstraverzije, otvorenosti ka iskustvu i savesnosti, serotoninski sistem učestvuje u mehanizmima povezanim sa povlačenjem i ihnibicijom, ali ima potencijalno značajnu ulogu u obradi i pozitivnih i negativnih stimulusa, dok moždani neurotrofni faktor pokazuje ulogu u kognitivnoj eksploraciji i plasticitetu ostalih sistema. Teorijske i praktične implikacije dobijenih rezultata komentarisane su u radu

Higher Education: The Impact on Bosnian Women Who Came as Refugees to the United States

This study examines the impact college education has on Bosnian refugee women who resettled to the United States. The research findings help us better understand the effect higher education has on female students who came to the United States as refugees, their self-sufficiency and their overall integration into their new society. Using Kunz’s refugee theory and Bourdieu’s theory on social and cultural capital as a theoretical framework, the study explores socio-cultural factors that enable and constrain the ability of Bosnian women to navigate the facets of higher education, and how those factors affect their self-sufficiency and overall integration. The participants came to the United States from Bosnia and Herzegovina as refugees during the mid-1990s and early 2000, and are first generation Bosnian or Bosnian-Americans living throughout the United States. The Bosnian women range in age from 26 to 40, and achieved levels of education ranging from a current undergraduate to doctorates. Narrative inquiry methodology was used to represent the ten participants through their personal stories. Data collection methods included recorded individual in-depth interviews along with field notes, and a focus group follow-up. The study results illustrate how Bosnian women’s multiple uprooted experiences as refugees affected their educational experiences and their disposition toward a college education. A rich account of the women’s complex experiences in their native country, temporary exile, and the United States, provides educators, educational policy makers, professional staff, and the host community a framework for how to efficiently support Bosnian refugee students as they integrate into their new community and bridge into higher education. Recommendations for other refugee communities and the U.S. refugee policy makers to support effective integration of refugees are also provided

Bihevioralnogenetičke osnove petofaktorskog modela ličnosti

Petofaktorski model ličnosti pretpostavlja da se osobine ličnosti mogu razumeti u terminima bazičnih pet domena: neuroticizma, ekstraverzije, otvorenosti ka iskustvu, prijatnosti i savesnosti. Pošto je razvoj ličnosti posledica složenih odnosa gena i sredine, osnovno teorijsko i istraživačko pitanje savremene bijevioralne genetike jeste na koji način geni i sredina oblikuju osobine. Osnovni ciljevi istraživanja bili su ispitivanje genskih i sredinskih faktora koji doprinose objašnjenju individualnih razlika na domenima i aspektima petofaktorskog modela ličnosti i veze između genotipova HTR1A, TPH2, BDNF, COMT, DRD2 i OXTR gena, njihovih epistatičkih efekata i dimenzija ličnosti petofaktorskog modela. U Studiji 1 učestvovala su 362 monozigotna i 210 dizigotna blizanaca iz Republike Srbije (M = 24,88; SD = 6,94). U Studiji 2 učestvovalo je 474 ispitanika iz Studije 1 (M = 24,48; SD = 7,58). Korišćeni instrumenti su revidirani NEO-PI-R inventar ličnosti (Costa & McCrae, 2019, adaptacija Knežević et al., 2004), zigotnost procenjena iz DNK bukalnog brisa i pojedinačni nukleotidni polimorfizmi HTR1A (rs6295), TPH2 (rs4570625), BDNF (rs6265), COMT (rs4680), DRD2 (rs1800497) i OXTR (rs53576) gena. Rezultati Studije 1 ukazuju na to da osobine ličnosti petofaktorskog modela pokazuju značajne aditivne genske i nedeljene sredinske doprinose, kao i da neki aspekti unutar domena imaju jake zajedničke osnove, dok su neki drugi gotovo nezavisni. Studija 2 sugeriše da serotoninski, dopaminski, oksitocin i moždani neurotrofni faktor sistemi gena leže u osnovi kompleksnih ponašanja, sa potencijalno različitim efektima na pojedinačne osobine ličnosti. Uloga dopaminskog genskom sistema najznačajnija je za domen ekstraverzije, otvorenosti ka iskustvu i savesnosti, serotoninski sistem učestvuje u mehanizmima povezanim sa povlačenjem i ihnibicijom, ali ima potencijalno značajnu ulogu u obradi i pozitivnih i negativnih stimulusa, dok moždani neurotrofni faktor pokazuje ulogu u kognitivnoj eksploraciji i plasticitetu ostalih sistema. Teorijske i praktične implikacije dobijenih rezultata komentarisane su u radu