Applications of GridProbe technology for traffic monitoring on high-capacity backbone networks, data-link layer simulation approach

This paper covers the on-going research on MASTSproject. The project objectives are to set-up and exploit a trafficmonitoring system for the UKLIGHT international high capacityexperimental network. The proposed system will record data flowand topological information at a range of time scales (fromfractions of a second to years). It will make this informationavailable to the community as a web service and managementinterfaces. In this paper the focus is on development of simulationplatforms that enable testing the analysis algorithms and Webservices output

An exploratory study of the vortex sheets shed from the leading edges of slender wings

Analysis of vortex sheets shed from leading edges of slender wing

A theoretical investigation of the aerodynamics of slender wing-body combinations exhibiting leading-edge separation

Theoretical investigation of aerodynamics of slender wing-body combinations exhibiting leading edge separatio

Modified NASA-Lewis chemical equilibrium code for MHD applications

A substantially modified version of the NASA-Lewis Chemical Equilibrium Code was recently developed. The modifications were designed to extend the power and convenience of the Code as a tool for performing combustor analysis for MHD systems studies. The effect of the programming details is described from a user point of view

Theoretical and experimental study of the elastic behavior of the human brachial and other human and canine arteries

Elastic behavior of human brachial and other human and canine arteries analyzed by nonlinear membrane theor

Interactional Structure Applied to the Identification and Generation of Visual Interactive Behavior: Robots that (Usually) Follow the Rules

Peer reviewe

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nutrients to promote the abundance and activity of UCP1 is not well established. Caffeine consumption has been associated with loss of body weight and increased energy expenditure, but whether it can activate UCP1 is unknown. This study examined the effect of caffeine on BAT thermogenesis in vitro and in vivo. Stem cell-derived adipocytes exposed to caffeine (1 mM) showed increased UCP1 protein abundance and cell metabolism with enhanced oxygen consumption and proton leak. These functional responses were associated with browning-like structural changes in mitochondrial and lipid droplet content. Caffeine also increased peroxisome proliferator-activated receptor gamma coactivator 1-alpha expression and mitochondrial biogenesis, together with a number of BAT selective and beige gene markers. In vivo, drinking coffee (but not water) stimulated the temperature of the supraclavicular region, which co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis. Taken together, these results demonstrate that caffeine can promote BAT function at thermoneutrality and may have the potential to be used therapeutically in adult humans