A study of the effects of a social problem solving intervention with emotionally disturbed youth at a special services school

The purpose of this pretest-posttest descriptive study was to examine the efficacy of a SPS training intervention for emotionally disturbed children in the special education system, with respect to social skills acquisition, family environment, reduction in non-compliant behaviors and sociometric status. Participants included eighteen students in four self-contained classrooms of a Special Services Regional Day School. The sample included one white female, eleven white males, three black and three Hispanic males with a mean age of eleven years and ten months. All classes were exposed to a six month program with lessons from the Readiness Phase of Elias and Clabby\u27s (1989) Social Decision-Making Skills: A Curriculum Guide for Elementary Grades. Teachers completed the Social Problem Solving Checklist at pre and postintervention. Ex post facto data were collected from student files and sociometric data came from teacher interviews. In general, percentage of change indicated that SPS training had positive effects on self-control and group participation skills and non-compliant behaviors decreased. This study highlighted the efficacy of preventative approaches and longitudinal research was recommended to evaluate the long term benefits of SPS training of emotionally disturbed children

Advanced feed system component interaction analysis Quarterly status letter, 30 Jun. - 30 Sep. 1969

Dynamic model of Mars Mariner 1969 pressure regulato

Factors Affecting the Production of Staphylocoagulase in a Chemically Defined Medium

Author Institution: Department of Biology and College of Pharmacy, University of Toledo, Toledo 6, Ohi

A Bayesian approach to analysing cortico-cortical associative stimulation induced increases in the excitability of corticospinal projections in humans

Repeated pairing of transcranial magnetic stimulation (TMS) over left and right primary motor cortex (M1), at intensities sufficient to generate descending volleys, produces sustained increases in corticospinal excitability. In other paired associative stimulation (PAS) protocols, in which peripheral afferent stimulation is the first element, changes in corticospinal excitability achieved when the second stimulus consists of brief bursts of transcranial alternating current stimulation (tACS), are comparable to those obtained if TMS is used instead (McNickle and Carson 2015). The present aim was to determine whether associative effects are induced when the first stimulus of a cortico-cortical pair is tACS, or alternatively subthreshold TMS. Bursts of tACS (500 ms; 140 Hz; 1 mA) were associated (180 stimulus pairs) with single magnetic stimuli (120% resting motor threshold rMT) delivered over the opposite (left) M1. The tACS ended 6 ms prior to the TMS. In a separate condition, TMS (55% rMT) was delivered to right M1 6 ms before (120% rMT) TMS was applied over left M1. In a sham condition, TMS (120% rMT) was delivered to left M1 only. The limitations of null hypothesis significance testing are well documented. We therefore employed Bayes factors to assess evidence in support of experimental hypotheses—defined precisely in terms of predicted effect sizes, that these two novel variants of PAS increase corticospinal excitability. Although both interventions induced sustained (~ 20–30 min) increases in corticospinal excitability, the evidence in support of the experimental hypotheses (over specified alternatives) was generally greater for the paired TMS-TMS than the tACS-TMS conditions

The effects of maternal social phobia on mother-infant interactions and infant social responsiveness

Background: Social phobia aggregates in families. The genetic contribution to intergenerational transmission is modest, and parenting is considered important. Research on the effects of social phobia on parenting has been subject to problems of small sample size, heterogeneity of samples and lack of specificity of observational frameworks. We addressed these problems in the current study.Methods: We assessed mothers with social phobia (N = 84) and control mothers (N = 89) at 10 weeks in face-to-face interactions with their infants, and during a social challenge, namely, engaging with a stranger. We also assessed mothers with generalised anxiety disorder (GAD) (N = 50). We examined the contribution to infant social responsiveness of early infant characteristics (neonatal irritability), as well as maternal behaviour. Results: Mothers with social phobia were no less sensitive to their infants during face-to-face interactions than control mothers, but when interacting with the stranger they appeared more anxious, engaged less with the stranger themselves, and were less encouraging of the infant's interaction with the stranger; infants of index mothers also showed reduced social responsiveness to the stranger. These differences did not apply to mothers with GAD and their infants. Regression analyses showed that the reduction in social responsiveness in infants of mothers with social phobia was predicted by neonatal irritability and the degree to which the mother encouraged the infant to interact with the stranger.Conclusions: Mothers with social phobia show specific parenting difficulties, and their infants show early signs of reduced social responsiveness that are related to both individual infant differences and a lack of maternal encouragement to engage in social interactions

Movers and shakers: Granular damping in microgravity

The response of an oscillating granular damper to an initial perturbation is studied using experiments performed in microgravity and granular dynamics mulations. High-speed video and image processing techniques are used to extract experimental data. An inelastic hard sphere model is developed to perform simulations and the results are in excellent agreement with the experiments. The granular damper behaves like a frictional damper and a linear decay of the amplitude is bserved. This is true even for the simulation model, where friction forces are absent. A simple expression is developed which predicts the optimal damping conditions for a given amplitude and is independent of the oscillation frequency and particle inelasticities.Comment: 9 pages, 9 figure

Structuring Joint Action Routines: A Strategy for Facilitating Communication and Language Development in the Classroom

The study of early child language has produced a wealth of new data and con­comitant theories over the past decade, and these new perspectives offer important im­plications to those of us engaged in clinical practice. We have noted elsewhere that this current literature on early child language has specific implications for designing ap­propriate targets, contexts, and procedures for language therapy (McLean and Snyder-­McLean, 1978; McLean, Snyder-McLean, and Sack, 1983). In this article, we will con­centrate on these two latter areas: contexts and procedures for language intervention and, more specifically, on the combination of these elements in the form of structured joint action routines

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria

Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have been promising with regard to its revival in malaria therapy. The objective of this study was to assess the safety and efficacy of two MB-based malaria combination therapies, MB-artesunate (AS) and MB-amodiaquine (AQ), compared to the local standard of care, AS-AQ, in Burkina Faso. Open-label randomised controlled phase II study in 180 children aged 6-10 years with uncomplicated falciparum malaria in Nouna, north-western Burkina Faso. Follow-up was for 28 days and analysis by intention-to-treat. The treatment groups were similar in baseline characteristics and there was only one loss to follow-up. No drug-related serious adverse events and no deaths occurred. MB-containing regimens were associated with mild vomiting and dysuria. No early treatment failures were observed. Parasite clearance time differed significantly among groups and was the shortest with MB-AS. By day 14, the rates of adequate clinical and parasitological response after PCR-based correction for recrudescence were 87% for MB-AS, 100% for MB-AQ (p = 0.004), and 100% for AS-AQ (p = 0.003). By day 28, the respective figure was lowest for MB-AS (62%), intermediate for the standard treatment AS-AQ (82%; p = 0.015), and highest for MB-AQ (95%; p<0.001; p = 0.03). MB-AQ is a promising alternative drug combination against malaria in Africa. Moreover, MB has the potential to further accelerate the rapid parasite clearance of artemisinin-based combination therapies. More than a century after the antimalarial properties of MB had been described, its role in malaria control deserves closer attention. ClinicalTrials.gov NCT00354380

Gating of aqùaporins by light and reactive oxygen species in leaf parenchyma cells of the midrib of Zea mays

Changes of the water permeability aqùaporin (AQP) activity of leaf cells were investigated in response to different light regimes (low versus high). Using a cell pressure probe, hydraulic properties (half-time of water exchange, T1/2 ∞ 1/water permeability) of parenchyma cells in the midrib tissue of maize (Zea mays L.) leaves have been measured. A new perfusion technique was applied to excised leaves to keep turgor constant and to modify the environment around cells by perfusing solutions using a pressure chamber. In response to low light (LL) of 200 μmol m−2 s−1, T1/2 decreased during the perfusion of a control solution of 0.5 mM CaCl2 by a factor of two. This was in line with earlier results from leaf cells of intact maize plants at a constant turgor. In contrast, high light (HL) at intensities of 800 μmol m−2 s−1 and 1800 μmol m−2 s−1 increased the T1/2 in two-thirds of cells by factors of 14 and 35, respectively. The effects of HL on T1/2 were similar to those caused by H2O2 treatment in the presence of Fe2+, which produced ·OH (Fenton reaction; reversible oxidative gating of aquaporins). Treatments with 20 mM H2O2 following Fe2+ pre-treatments increased the T1/2 by a factor of 30. Those increased T1/2 values could be partly recovered, either when the perfusion solution was changed back to the control solutuion or when LL was applied. 3mM of the antioxidant glutathione also reversed the effects of HL. The data suggest that HL could induce reactive oxygen species (ROS) such as ·OH, and they affected water relations. The results provide evidence that the varying light climate adjusts water flow at the cell level; that is, water flow is maximized at a certain light intensity and then reduced again by HL. Light effects are discussed in terms of an oxidative gating of aquaporins by ROS