Quadratic Cones and AutoCAD

Raspravlja se o kosim kružnim stošcima i stošcima 2. stupnja, uglavnom s obzirom na izvedbu u računalnim algebarskim i CAD sistemima, posebno AutoCAD-u.Oblique circular cones and quadratic cones are discussed mainly with respect to implementations in Computer Algebra systems and CAD systems especially AutoCAD

Collaborative design in virtual environments

How can architects and engineers work together in the digital world? The article "Collaborative Design in Virtual Environments" provides an answer. The authors describe how the use of virtual reality (VR) and augmented reality (AR) is becoming increasingly important in the architecture industry and what opportunities this opens up. In particular, the article focuses on collaboration in virtual spaces and collaborative modeling of 3D objects. The authors also present a software tool that enables collaborative 3D modeling in virtual environments. The aim of the "Industry 4.0 in Teaching" project is to promote collaboration and joint learning and to prepare students for the requirements of the digital working world. (Editor)Wie können Architekten und Ingenieure in der digitalen Welt zusammenarbeiten? Eine Antwort darauf liefert der Artikel "Collaborative Design in Virtual Environments". Die Autoren beschreiben, wie die Anwendung von Virtual Reality (VR) und Augmented Reality (AR) in der Architekturbranche immer wichtiger wird und welche Möglichkeiten sich daraus ergeben. Insbesondere die Zusammenarbeit in virtuellen Räumen und die gemeinsame Modellierung von 3D-Objekten stehen im Fokus des Artikels. Die Autoren stellen außerdem ein Software-Tool vor, das die kollaborative 3D-Modellierung in virtuellen Umgebungen ermöglicht. Das Ziel des Projekts "Industry 4.0 in Teaching" ist es, die Zusammenarbeit und das gemeinsame Lernen zu fördern und die Studierenden auf die Anforderungen der digitalen Arbeitswelt vorzubereiten. (Herausgeber

Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment

Background. Analysis of isoniazid (INH) uptake has been based on measurement of plasma concentrations providing a short-term and potentially biased view. Objectives. To establish hair analysis as a tool to measure long-term uptake of INH and to assess whether acetylator phenotype in hair reflects N-acetyltransferase-2 (NAT2) genotype. Design and Methods. INH and acetyl-INH concentrations in hair were determined in patients on INH treatment for M. tuberculosis infection using high pressure liquid chromatography/mass spectrometry. Acetyl-INH/INH ratios were correlated with NAT-2 genotype. Results. Hair concentrations of INH, determined in 40 patients, were not dependent on ethnic group or body mass index and were significantly higher in male compared to female patients (median (range) 2.37 ng/mg (0.76–4.9) versus 1.11 ng/mg (0.02–7.20) (P = 0.02). Acetyl-INH/INH ratios were a median of 15.2% (14.5 to 31.7) in homozygous rapid acetylator NAT-2 genotype and 37.3% (1.73 to 51.2) in the heterozygous rapid acetylator NAT-2 genotype and both significantly higher than in the slow acetylator NAT-2 genotype with 5.8% (0.53 to 14.4) (P < 0.05). Conclusions. Results of hair analysis for INH showed lower concentrations in females. Acetyl-INH/INH ratios were significantly lower in patients with slow acetylator versus rapid acetylator genotypes