FORMULATION AND IN VITRO, IN VIVO EVALUATION OF PRONIOSOMAL GEL OF NEOMYCIN SULPHATE

Objective: The objectives of present investigation were to prepare and evaluate proniosomes of neomycin sulphate (NS) by coacervation phase separation method by using sorbitan monostearate (span 60) and lecithin as a surfactant to increase the penetration through the skin and study the effect of concentration of the same. Methods: Proniosomes of neomycin sulphate (NS) were prepared by coacervation phase separation method by using span 60 and lecithin. The effect of concentration of span 60 and lecithin was studied by factorial design. The prepared proniosomes were converted to gel by using carbopol as a gelling agent. The prepared formulations were evaluated for entrapment efficiency, in vitro drug diffusion, in vitro antibacterial activity and in vivo skin irritation test etc. Results: All Formulation showed the percentage entrapment efficiency in the range 38.31±0.05% to 77.96±0.06%, good homogeneity and gel was easily spreadable with minimal of shear. Optimized formulation showed enhanced rate of diffusion in vitro, increase in zone of inhibition against staphylococcus aureus, no skin irritation and showed good stability. Conclusion: The results of present study indicates that proniosomal gel formulated by using combination of span 60, Lecithin, cholesterol can be used to enhance skin delivery of NS because of excellent permeation of drug. Developed proniosomal gel formulation was promising carrier for N

Heterogeneous Sim-Rank System For Image Intensional Search

An image-rich information network is a social media site for uploading images by users which are associated with information about user, consumer producer, annotations .It uses a combined approach which measures the similarity based on both link based and Content based. The link based similarity depends upon the social network information like tags, groups and annotation over the images .Content based similarity considers the image content properties edge, color histogram, texture shape etc. Then, by considering the network structure and reinforcing link similarity use an algorithm Integrated Weighted Similarity Learning (IWSL) to find both link-based and content based similarities. The combination of two methods to integrate the social resources and helps to classify the images in image-rich information networks. It implements a new search engine system to find relevant products from online medi

The influence of particle(s) size, shape and distribution on cake filtration mechanics—a short review

The filtration properties in solid–liquid separation mainly depend upon the filter cake properties, for instance, cake resistance. However, particle size distribution, particle shape, and their arrangements significantly impact cake filtration. This paper aims to review the work done so far and collate both fundamental and applied work with regard to the quantification of cake properties. The cake resistance and cake porosity in terms of shape, as well as varying particle size distribution width, are discussed here. This work summarizes the current state of the technology and recommends advancements and improvements for future research

The influence of particle(s) size, shape and distribution on cake filtration mechanics—a short review

The filtration properties in solid–liquid separation mainly depend upon the filter cake properties, for instance, cake resistance. However, particle size distribution, particle shape, and their arrangements significantly impact cake filtration. This paper aims to review the work done so far and collate both fundamental and applied work with regard to the quantification of cake properties. The cake resistance and cake porosity in terms of shape, as well as varying particle size distribution width, are discussed here. This work summarizes the current state of the technology and recommends advancements and improvements for future research

COMPUTATIONAL ANALYSIS OF INTERCITY BUS WITH IMPROVED AESTHETICS AND AERODYNAMIC PERFORMANCE ON INDIAN ROADS

ABSTRACT For buses which covers long distances in a single stretch, improved aerodynamic design with good aesthetics attracts customers besides saving fuel consumption. Ergonomic design of interiors for increased comfort of the passengers also plays a vital role. In the present work emphasis is given on the redesign of an intercity bus with enhanced exterior styling reduced aerodynamic drag and increased comfort for the passengers. Extensive product study and market study are carried out. Existing intercity bus is benchmarked and analyzed for styling, aerodynamic performance and comfort. Fluent, a CFD code is used to evaluate the aerodynamic performance. Principles of product design are used to analyze the styling and comfort. The benchmarked high-floor bus is redesigned with low -floor for reduced aerodynamic drag. The exterior of the chosen bus is redesigned with emphasis on improvised aerodynamic performance and appealing looks. The interior was modified to meet aspirations of the commuters. The results of the redesigned exterior body showed a reduction of C d from 0.581 to 0.41 at a speed of 100 km/hr and overall aerodynamic drag reduction by about 30% due to combined effect of reduced C d and frontal area

Formulation, drying and nutritional evaluation of ready-to-eat sapota (Achras zapota) extrudes

10.2202/1556-3758.2106International Journal of Food Engineering71

Rapid synthesis and decoration of reduced graphene oxide with gold nanoparticles by thermostable peptides for memory device and photothermal applications

This article presents novel, rapid, and environmentally benign synthesis method for one-step reduction and decoration of graphene oxide with gold nanoparticles (NAuNPs) by using thermostable antimicrobial nisin peptides to form a gold-nanoparticles-reduced graphene oxide (NAu-rGO) nanocomposite. The formed composite material was characterized by UV/Vis spectroscopy, X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy, field emission scanning electron microscopy, and high-resolution transmission electron microscopy (HR-TEM). HR-TEM analysis revealed the formation of spherical AuNPs of 5–30 nm in size on reduced graphene oxide (rGO) nanosheets. A non-volatile-memory device was prepared based on a solution-processed ZnO thin-film transistor fabricated by inserting the NAu-rGO nanocomposite in the gate dielectric stack as a charge trapping medium. The transfer characteristic of the ZnO thin-film transistor memory device showed large clockwise hysteresis behaviour because of charge carrier trapping in the NAu-rGO nanocomposite. Under positive and negative bias conditions, clear positive and negative threshold voltage shifts occurred, which were attributed to charge carrier trapping and de-trapping in the ZnO/NAu-rGO/SiO2 structure. Also, the photothermal effect of the NAu-rGO nanocomposites on MCF7 breast cancer cells caused inhibition of ~80% cells after irradiation with infrared light (0.5 W cm−2) for 5 min

Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A_2A Receptor Antagonists and Their Biological Evaluation

Our initial structure–activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the 2-position led to identification of compound <b>25</b> as a potent and selective A_2A adenosine receptor (A_2AAdoR) antagonist with reasonable ADME and pharmacokinetic properties. However, poor intrinsic solubility and low to moderate oral bioavailability made this series unsuitable for further development. Further optimization using structure-based drug design approach resulted in discovery of potent and selective adenosine A_2A receptor antagonists bearing substituted 1-methylcyclohexyl-carboxamide groups at position 2 of the benzothiazole scaffold and endowed with better solubility and oral bioavailability. Compounds <b>41</b> and <b>49</b> demonstrated a number of positive attributes with respect to in vitro ADME properties. Both compounds displayed good pharmacokinetic properties with 63% and 61% oral bioavailability, respectively, in rat. Further, compound <b>49</b> displayed oral efficacy in 6-OHDA lesioned rat model of Parkinson diseases