410 research outputs found
Formulation and Evaluation of Polyherbal Anthelmintic Preparation
The present study was done with the aim to formulate an anthelmintic preparation and to evaluate anthelmintic activity of formulation containing traditionally user herbs viz., Plumbago zeylanica (leaves), Hyoscyamus niger (roots) and Abultion indicum (leaves) using adult earthworm Pheritima posthuma. The aqueous and ethanolic extract of the crude drug of different concentration were tested which involve determination of paralysis time and time to kill the worms. Piperazine citrate was used as standard and it was found that the PHFEE activity is higher than PHFAE
Role of adipokines, oxidative stress, and endotoxins in the pathogenesis of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
Background: Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation and oxidative stress, implicated in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Present study aimed to assess the role of adipokines, oxidative stress, and endotoxins in the pathogenesis of NAFLD in T2DM.Methods: Present cross-sectional observational study included healthy controls (n=50; group 1); T2DM patients without NAFLD (n=50; group 2), T2DM patients with NAFLD (n=50; group 3). Study subjects were age and gender matched.Results: Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high sensitive C-reactive protein (hs-CRP), endotoxin, malondialdehyde (MDA) were significantly elevated and adiponectin, ferric reducing ability of plasma (FRAP), and glutathione (GSH) were significantly lower (p<0.001) in T2DM patients with NAFLD when compared to T2DM patients without NAFLD and controls. Endotoxin showed significant positive correlation with TNF-α (r=0.304; p<0.001), hs-CRP (r=0.193; p=0.018), and MDA (r=0.420; p<0.001), and significant negative correlation with adiponectin (r=-0.406; p<0.001). TNF-α and IL-6 showed significant positive correlation with MDA (r=0.526; p<0.001, r=0.229; p=0.005) and significant negative correlation with adiponectin (r=-0.396; p<0.001, r=-0.318; p<0.001), FRAP (r=-0.418; p<00.001, r=-0.170; p=0.038), and GSH (r=-0.353; p<0.001, r=-0.301; p<0.001).Conclusions: Authors observed elevated endotoxin, oxidative stress, inflammation and lower adiponectin levels in T2DM subjects compared to controls. These changes were more pronounced in T2DM with NAFLD when compared to T2DM without NAFLD. Lower adiponectin levels were found to be a better predictor of NALFD in T2DM and is associated with oxidative stress and systemic inflammation
Thickness-dependent spontaneous dewetting morphology of ultrathin Ag films
We show here that the morphological pathway of spontaneous dewetting of
ultrathin Ag films on SiO2 under nanosecond laser melting is found to be film
thickness dependent. For films with thickness h between 2 <= h <= 9.5 nm, the
morphology during the intermediate stages of dewetting consisted of
bicontinuous structures. For films 11.5 <= h <= 20 nm, the intermediate stages
consisted of regularly-sized holes. Measurement of the characteristic length
scales for different stages of dewetting as a function of film thickness showed
a systematic increase, which is consistent with the spinodal dewetting
instability over the entire thickness range investigated. This change in
morphology with thickness is consistent with observations made previously for
polymer films [A. Sharma et al, Phys. Rev. Lett., v81, pp3463 (1998); R.
Seemann et al, J. Phys. Cond. Matt., v13, pp4925, (2001)]. Based on the
behavior of free energy curvature that incorporates intermolecular forces, we
have estimated the morphological transition thickness for the intermolecular
forces for Ag on SiO2 . The theory predictions agree well with observations for
Ag. These results show that it is possible to form a variety of complex Ag
nanomorphologies in a consistent manner, which could be useful in optical
applications of Ag surfaces, such as in surface enhanced Raman sensing.Comment: 20 pages, 5 figure
Stripe orders in the extended Hubbard model
We study stripe orders of charge and spin density waves in the extended
Hubbard model with the nearest-neighbor Coulomb repulsion V within the mean
field approximation. We obtain V vs. T(temperature) phase diagram for the
on-site Coulomb interaction U/t=8.0 and the filling n=0.8, here t is a
nearest-neighbor transfer energy. Our result shows that the diagonal stripe
spin density wave state (SDW) is stable for small V, but for large V the most
stable state changes to a charge density wave-antiferromagnetic (CDW-AF) state.
Especially we find at low temperature and for a certain range of value of V, a
vertical stripe CDW-AF state becomes stable.Comment: LaTeX 9 pages, 17 figures, uses jpsj.st
Neutron diffraction study of stripe order in La(2)NiO(4+d) with d=2/15
We report a detailed neutron scattering study of the ordering of spins and
holes in oxygen-doped La(2)NiO(4.133). The single-crystal sample exhibits the
same oxygen-interstitial order but better defined charge-stripe order than that
studied previously in crystals with d = 0.125. In particular, charge order is
observed up to a temperature at least twice that of the magnetic transition,
T_m = 110.5 K. On cooling through T_m, the wave vector \epsilon, equal to half
the charge-stripe density within an NiO(2) layer, jumps discontinuously from
1/3 to 0.2944. It continues to decrease with further cooling, showing several
lock-in transitions on the way down to low temperature. To explain the observed
lock-ins, a model is proposed in which each charge stripe is centered on either
a row of Ni or a row of O ions. The model is shown to be consistent with the
l-dependence of the magnetic peak intensities and with the relative intensities
of the higher-order magnetic satellites. Analysis of the latter also provides
evidence that the magnetic domain walls (charge stripes) are relatively narrow.
In combination with a recent study of magnetic-field-induced effects, we find
that the charge stripes are all O-centered at T>T_m, with a shift towards Ni
centering at T<T_m. Inferences concerning the competing interactions
responsible for the the temperature dependence of \epsilon and the localization
of charge within the stripes are discussed.Comment: ReVTeX, 17 2-col pages, 10 eps figs. embedded with psfig, submitted
to Phys. Rev.
Antiferromagnetic spin ladders effectively coupled by one-dimensional electron liquids
We study a model of the stripe state in strongly correlated systems
consisting of an array of antiferromagnetic spin ladders, each with
legs, coupled to each other through the spin-exchange interaction to charged
stripes in between each pair of ladders. The charged stripes are assumed to be
Luttinger liquids in a spin-gap regime (Luther-Emery). An effective interaction
for a pair of neighboring ladders is calculated by integrating out the gapped
spin degree of freedom in the charged stripe. The low energy effective theory
of each ladder is the usual nonlinear -model with additional cross
couplings of neighboring ladders. These interactions are found to favor either
in-phase or anti-phase short range spin orderings depending on whether the
charge stripe is site-centered or bond-centered as well as on its filling
factor and other physical parameters of the charged stripe.Comment: 4 pages with 1 figure, revised introduction and discussion section
Spin Dynamics in an Ordered Stripe Phase
Inelastic neutron scattering has been used to measure the low-energy spin
excitations in the ordered charge-stripe phase of La(2)NiO(4+d) with d=0.133.
Spin-wave-like excitations disperse away from the incommensurate magnetic
superlattice points with a velocity ~60% of that in the d=0 compound.
Incommensurate inelastic peaks remain well-resolved up to at least twice the
magnetic ordering temperature. Paramagnetic scattering from a d=0.105 sample,
which has a N\'eel-ordered ground state, shows anomalies suggestive of
incipient stripe correlations. Similarities between these results and
measurements on superconducting cuprates are discussed.Comment: 5 pp, 2 col., REVTeX, 4 epsf figures embedded with psfig; Abstract
and introduction have been revise
Erosion of Trust in the Medical Profession in India : Time for Doctors to Act
In India, over the last decade, a series of stewardship failures in the health system, particularly in the medical profession, have led to a massive erosion of trust in these institutions. In many low- and middle-income countries (LMICs), the situation is similar and has reached crisis proportions; this crisis requires urgent attention. This paper draws on the insights from the recent developments in India, to argue that a purely control-based regulatory response to this crisis in the medical profession, as is being currently envisaged by the Parliament and the Supreme Court of India, runs the risk of undermining the trusting interpersonal relations between doctors and their patients. A more balanced approach which takes into account the differences between system and interpersonal forms of trust and distrust is warranted. Such an approach should on one hand strongly regulate the institutions mandated with the stewardship and qualities of care functions, and simultaneously on the other hand, initiate measures to nurture the trusting interpersonal relations between doctors and patients. The paper concludes by calling for doctors, and those mandated with the stewardship of the profession, to individually and collectively, critically self-reflect upon the state of their profession, its priorities and its future direction
Spin and charge ordering in self-doped Mott insulators
We have investigated possible spin and charge ordered states in 3d
transition-metal oxides with small or negative charge-transfer energy, which
can be regarded as self-doped Mott insulators, using Hartree-Fock calculations
on d-p-type lattice models. It was found that an antiferromagnetic state with
charge ordering in oxygen 2p orbitals is favored for relatively large
charge-transfer energy and may be relevant for PrNiO and NdNiO. On the
other hand, an antiferromagnetic state with charge ordering in transition-metal
3 orbitals tends to be stable for highly negative charge-transfer energy and
can be stabilized by the breathing-type lattice distortion; this is probably
realized in YNiO.Comment: 4 pages, 4 figure
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