5,399 research outputs found

    PIN49 A PHARMACOECONOMIC EVALUATION OF INFLUENZA VACCINATION IN THE ELDERLY POPULATION IN ITALY

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    The effect of school design on users' responses: A systematic review (2008-2017)

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    This systematic review focused on the effect of the educational environment design on students and teachers performance, satisfaction, and wellbeing. Starting from a bulk of 1307 articles, a set of N = 68 empirical papers was selected and organized on the basis of four different content clusters, i.e., architectural building design and aesthetic features, indoor environmental features, classroom design, and school green spaces/outdoor spaces. From the analysis of research findings, the key role of pleasant, warm, and flexible learning environments emerged, for promoting both wellbeing and performance of users. More specifically, the presence of charming colors and pictures, ergonomic furniture, and adequate acoustic, thermal comfort, ventilation, and natural lighting have emerged as important features that school designers should care for. Furthermore, an integration of both indoor and outdoor learning situations showed to be effective for improving students learning and wellbeing

    Minimum error discrimination of Pauli channels

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    We solve the problem of discriminating with minimum error probability two given Pauli channels. We show that, differently from the case of discrimination between unitary transformations, the use of entanglement with an ancillary system can strictly improve the discrimination, and any maximally entangled state allows to achieve the optimal discrimination. We also provide a simple necessary and sufficient condition in terms of the structure of the channels for which the ultimate minimum error probability can be achieved without entanglement assistance. When such a condition is satisfied, the optimal input state is simply an eigenstate of one of the Pauli matrices.Comment: 8 pages, no figure

    Optimal discrimination of quantum operations

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    We address the problem of discriminating with minimal error probability two given quantum operations. We show that the use of entangled input states generally improves the discrimination. For Pauli channels we provide a complete comparison of the optimal strategies where either entangled or unentangled input states are used.Comment: 4 pages, no figure

    Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study

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    Y238, one of the very few conserved residues in the active site of d-amino acid oxidases (DAAO), was mutated to phenylalanine and serine in the enzyme from the yeast Rhodotorula gracilis. The mutated proteins are catalytically competent thus eliminating Tyr238 as an active-site acid/base catalyst. Y238F and Y238S mutants exhibit a threefold slower turnover on d-alanine as substrate, which can be attributed to a slower rate of product release relative to the wild-type enzyme (a change of the rate constants for substrate binding was also evident). The Y238 DAAO mutants have spectral properties similar to those of the wild-type enzyme but the degree of stabilization of the flavin semiquinone and the redox properties in the free form of Y238S are different. The binding of the carboxylic acid competitive inhibitors and the substrate d-alanine are changed only slightly, suggesting that the overall substrate binding pocket remains intact. In agreement with data from the pH dependence of ligand binding and with the protein crystal structure, site-directed mutagenesis results emphasize the importance of residue Y238 in controlling access to the active site instead of a role in the substrate/ligand interaction

    Chemical abundances and radial velocities in the extremely metal-poor galaxy DDO 68

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    We present chemical abundances and radial velocities of six HII regions in the extremely metal-poor star-forming dwarf galaxy DDO 68. They are derived from deep spectra in the wavelength range 3500 - 10,000 {\AA}, acquired with the Multi Object Double Spectrograph (MODS) at the Large Binocular Telescope (LBT). In the three regions where the [O III]λ\lambda4363 {\AA} line was detected, we inferred the abundance of He, N, O, Ne, Ar, and S through the "direct" method. We also derived the oxygen abundances of all the six regions adopting indirect method calibrations. We confirm that DDO 68 is an extremely metal-poor galaxy, and a strong outlier in the luminosity - metallicity relation defined by star-forming galaxies. With the direct-method we find indeed an oxygen abundance of 12+log(O/H)=7.14±\pm0.07 in the northernmost region of the galaxy and, although with large uncertainties, an even lower 12+log(O/H)=6.96±\pm0.09 in the "tail". This is, at face value, the most metal-poor direct abundance detection of any galaxy known. We derive a radial oxygen gradient of -0.06±\pm0.03 dex/kpc (or -0.30 dex R25−1R_{25}^{-1}) with the direct method, and a steeper gradient of -0.12±\pm0.03 dex/kpc (or -0.59 dex R25−1R_{25}^{-1}) from the indirect method. For the α\alpha-element to oxygen ratios we obtain values in agreement with those found in other metal-poor star-forming dwarfs. For nitrogen, instead, we infer much higher values, leading to log(N/O)∼−1.4\sim-1.4, at variance with the suggested existence of a tight plateau at −1.6-1.6 in extremely metal poor dwarfs. The derived helium mass fraction ranges from Y=0.240±\pm0.005 to Y=0.25±\pm0.02, compatible with standard big bang nucleosynthesis. Finally, we measured HII region radial velocities in the range 479−-522 km/s from the tail to the head of the "comet", consistent with the rotation derived in the HI.Comment: Accepted for publication in MNRA

    Resilience effects in food consumption behaviour at the time of Covid-19: Perspectives from Italy

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    The Covid-19 pandemic lead Italy to undertake a severe lockdown for almost two months. All of a sudden, the lives of Italians were forced to shift in accordance with the regulations issued by government. This change in the lives of Italians can be mirrored by an adjustment in food consumer behaviour that, consequently, brought about a transition in the whole supply chain. This paper gives an overview of the recent changes in consumption patterns that occurred due to the Italian lockdown, and how evolutions in behaviour are intertwined with the evolution of the main food supply chains. Many of the events here depicted are likely to last far beyond the crisis and affect the subsequent evolution of food consumption in Italy. The Italian retail supply chain successfully adapted to the big shift in consumption. Despite purchases for essential items having increased, no stockout harmed the food security of Italians. Out-of-home consumption moved inside houses giving space to home meal preparation and comfort food. Home delivery has been the most important element in this context, as it boomed during this period, helping laggard consumers fill the digital divide, as it was mostly mediated by e-commerce platforms and instant messaging. It was also the leverage that allowed small retailers and small producers regain their space. This crisis calls for a more sustainable food system that will be increasingly oriented to moving goods rather than people, which will also have relevance in the coming years

    Extremal equation for optimal completely-positive maps

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    We derive an extremal equation for optimal completely-positive map which most closely approximates a given transformation between pure quantum states. Moreover, we also obtain an upper bound on the maximal mean fidelity that can be attained by the optimal approximate transformation. The developed formalism is applied to universal-NOT gate, quantum cloning machines, quantum entanglers, and qubit theta-shifter.Comment: REVTeX, 7 pages, 2 figures, important reference adde
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