Alfabetización temprana en el niño sordo : una propuesta desde la conciencia dactilológica

Este trabajo parte del análisis y reflexión sobre las prácticas educativas en un primer grado de una escuela especial bilingüe para Sordos. De esta experiencia surge el interés de indagar estrategias que favorecieran el proceso de alfabetización del niño Sordo, incorporando la representación dactilológica de las palabras. Este trabajo se sustenta en la visión socioantropológica que conceptualiza a las personas Sordas como miembros de una comunidad lingüística minoritaria y a la sordera como una condición que es preciso respetar. Las personas Sordas hablan una lengua propia, la Lengua de Señas Argentina (LSA) y también desarrollan una cultura específica

Pre main sequence: Accretion & Outflows

Low-mass pre-main sequence (PMS) stars are strong X-ray sources, because they possess hot corona like their older main-sequence counterparts. Unique to young stars, however, are X-rays from accretion and outflows, and both processes are of pivotal importance for star and planet formation. We describe how X-ray data provide important insight into the physics of accretion and outflows. First, mass accreted from a circumstellar disk onto the stellar surface reaches velocities up to a few hundred km/s, fast enough to generate soft X-rays in the post-shock region of the accretion shock. X-ray observations together with laboratory experiments and numerical simulations show that the accretion geometry is complex in young stars. Specifically, the center of the accretion column is likely surrounded by material shielding the inner flow from view but itself also hot enough to emit X-rays. Second, X-rays are observed in two locations of protostellar jets: an inner stationary emission component probably related to outflow collimation and outer components, which evolve withing years and are likely related to working surfaces where the shock travels through the jet. Jet-powered X-rays appear to trace the fastest jet component and provide novel information on jet launching in young stars. We conclude that X-ray data will continue to be highly important for understanding star and planet formation, because they directly probe the origin of many emission features studied in other wavelength regimes. In addition, future X-ray missions will improve sensitivity and spectral resolution to probe key model parameters (e.g. velocities) in large samples of PMS stars.Comment: Invited chapter for the "Handbook of X-ray and Gamma-ray Astrophysics" (Eds. C. Bambi and A. Santangelo, Springer Nature, 2022), accepted (34 pages, 11 figures

Individual, Social, and Environmental Risk Factors of Malaria in Rote Ndao District, East Nusa Tenggara

Background: Malaria is one of the world\u27s biggest killers. Studies into indi¬vi-dual, social, and environmental risk factors of malaria in East Nusa Teng¬gara, In¬do¬nesia, are absent. This study aimed to investigate the individual, social, and environ¬mental risk factors of malaria in East Nusa Tenggara, Indonesia. Subjects and Method: This was a cross-sectional study conducted at Pus-kes¬mas Feapopi, Rote Ndao district, East Nusa Tenggara, Indonesia, from De-cem¬¬ber 2015 to February 2016. A total sample of 310 subjects was selected for this study by multi stage random sampling. The dependent variable was malaria. The indepen¬dent variables were mosquito repellent use, hanging out of the house in the evening, distance to a breeding place, type of house wall, distance to a stable, and health education on malaria. The data were collected by ques¬tion¬naire, interview, and observation. Malaria was diagnosed microscopically. The data were analyzed by a multiple logistic regression. Results: The risk of malaria increased with absence of mosquito repellent use (OR= 4.61; 95% CI= 1.75 to 12.16; p= 0.002), hanging out of the house in the evening (OR= 5.67; 95% CI= 2.32 to 13.82; p<0.001), close to a breeding place (OR= 3.54; 95% CI= 1.50 to 8.33; p= 0.004), semi-permanent house wall (OR= 8.13; 95% CI= 2.99 to 22.07; p<0.001), far from a stable (OR= 0.08; 95% CI= 0.03 to 0.23; p<0.001), and health education on malaria (OR= 0.06; 95% CI= 0.03 to 0.14; p<0.001). Conclusion: The risk of malaria increases with absence of mosquito repellent use, hanging out of the house in the evening, close to a breeding place, semi-per¬ma¬¬¬nent house wall, far from a stable, and health education on malaria. Keywords: individual, social, environment, risk factor, malaria

RhoJ/TCL Regulates Endothelial Motility and Tube Formation and Modulates Actomyosin Contractility and Focal Adhesion Numbers

Objective—RhoJ/TCL was identified by our group as an endothelial-expressed Rho GTPase. The aim of this study was to determine its tissue distribution, subcellular localization, and function in endothelial migration and tube formation. Methods and Results—Using in situ hybridization, RhoJ was localized to endothelial cells in a set of normal and cancerous tissues and in the vasculature of mouse embryos; endogenous RhoJ was localized to focal adhesions by immunofluorescence. The proangiogenic factor vascular endothelial growth factor activated RhoJ in endothelial cells. Using either small interfering (si)RNA-mediated knockdown of RhoJ expression or overexpression of constitutively active RhoJ (daRhoJ), RhoJ was found to positively regulate endothelial motility and tubule formation. Downregulating RhoJ expression increased focal adhesions and stress fibers in migrating cells, whereas daRhoJ overexpression resulted in the converse. RhoJ downregulation resulted in increased contraction of a collagen gel and increased phospho–myosin light chain, indicative of increased actomyosin contractility. Pharmacological inhibition of Rho-kinase (which phosphorylates myosin light chain) or nonmuscle myosin II reversed the defective tube formation and migration of RhoJ knockdown cells. Conclusion—RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers

Associations between rationing of nursing care and inpatient mortality in Swiss hospitals

Objectives To explore the relationship between inpatient mortality and implicit rationing of nursing care, the quality of nurse work environments and the patient-to-nurse staffing ratio in Swiss acute care hospitals. Design Cross-sectional correlational design. Setting Eight Swiss acute care hospitals examined in a survey-based study and 71 comparison institutions. Participants A total of 165 862 discharge abstracts from patients treated in the 8 RICH Nursing Study (the Rationing of Nursing Care in Switzerland Study) hospitals and 760 608 discharge abstracts from patients treated in 71 Swiss acute care hospitals offering similar services and maintaining comparable patient volumes to the RICH Nursing hospitals. Main outcome measures The dependent variable was inpatient mortality. Logistic regression models were used to estimate the effects of the independent hospital-level measures. Results Patients treated in the hospital with the highest rationing level were 51% more likely to die than those in peer institutions (adjusted OR: 1.51, 95% CI: 1.34-1.70). Patients treated in the study hospitals with higher nurse work environment quality ratings had a significantly lower likelihood of death (adjusted OR: 0.80, 95% CI: 0.67-0.97) and those treated in the hospital with the highest measured patient-to-nurse ratio (10:1) had a 37% higher risk of death (adjusted OR: 1.37, 95% CI: 1.24-1.52) than those in comparison institutions. Conclusions Measures of rationing may reflect care conditions that place hospital patients at risk of negative outcomes and thus deserve attention in future hospital outcomes research studie

Prevalence of drug-herb and drug-supplement interactions in older adults : A cross-sectional survey

© British Journal of General PracticeBackground Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults. Aim To establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions. Design and setting Cross-sectional survey of older adults registered at two general practices in South East England. Method A questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug. Results In total 155 questionnaires were returned (response rate = 38.8%) and the prevalence of concurrent HMPs and dietary supplements with prescriptions was 33.6%. Females were more likely than males to be concurrent users (43.4% versus 22.5%; P = 0.009). The number of HMPs and dietary supplements ranged from 1 to 8, (mean = 3, median = 1; standard deviation = 1.65). The majority of concurrent users (78.0%) used dietary supplements with prescription drugs. The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and Vitamin D. Others (20.0%) used only HMPs with prescription drugs. Common HMPs were evening primrose oil, valerian, and Nytol Herbal® (a combination of hops, gentian, and passion flower). Sixteen participants (32.6%) were at risk of potential adverse drug interactions. Conclusion GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.Peer reviewe

La eficacia probatoria del instrumento público : Art. 296 del CCCN

En el ámbito jurídico existen normas y hechos. Al derecho le importa la existencia, la persistencia, la prueba, la valoración y la eficacia de los hechos que se relacionan directamente con la calidad del instrumento. A mayor credibilidad mayor fuerza probatoria. El artículo regula la eficacia probatoria y la plena fe del instrumento público que implica “autenticación”. Se resguarda la consecuencia de la aplicación de la fe pública: el principio de autenticidad de los instrumentos públicos y la seguridad jurídica. La autenticidad del instrumento público se constituye “a priori” y el instrumento público tendrá la fuerza de auténtico hasta la sentencia que pronuncie su falsedad. El Código Civil y Comercial mantiene la regulación velezana de los arts.993 y 994 con una redacción mejorada.Facultad de Ciencias Jurídicas y Sociale

Wireless magnetoelectrically powered organic light-emitting diodes

This work was supported by a scholarship to J.F.B. donated by Beverly and Frank MacInnis to the University of St Andrews, the European Union Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement no. 101023743 (PolDev to A.M.), The Leverhulme Trust (RPG-2017-231), the Alexander von Humboldt Foundation (Humboldt Professorship to M.C.G.), the DFG-funded Research Training Group “Template-Designed Organic Electronics (TIDE)” (RTG2591), and the EPSRC NSF-CBET lead agency agreement (EP/R010595/1, 1706207).Compact wireless light sources are a fundamental building block for applications ranging from wireless displays to optical implants. However, their realization remains challenging because of constraints in miniaturization and the integration of power harvesting and light-emission technologies. Here, we introduce a strategy for a compact wirelessly powered light-source that consists of a magnetoelectric transducer serving as power source and substrate and an antiparallel pair of custom-designed organic light-emitting diodes. The devices operate at low-frequency ac magnetic fields (~100 kHz), which has the added benefit of allowing operation multiple centimeters deep inside watery environments. By tuning the device resonance frequency, it is possible to separately address multiple devices, e.g., to produce light of distinct colors, to address individual display pixels, or for clustered operation. By simultaneously offering small size, individual addressing, and compatibility with challenging environments, our devices pave the way for a multitude of applications in wireless displays, deep tissue treatment, sensing, and imaging.Peer reviewe