Previously Identified Genetic Variants in ADGRL3 Are not Associated with Risk for Equine Degenerative Myeloencephalopathy across Breeds.

Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurologic disease that has been reported in young horses from a wide range of breeds. The disease is inherited and associated with vitamin E deficiency during the first two years of life, resulting in bilateral symmetric ataxia. A missense mutation (chr3:71,917,591 C > T) within adhesion G protein-coupled receptor L3 (ADGRL3) was recently associated with risk for EDM in the Caspian breed. In order to confirm these findings, genotyping of this missense mutation, along with the three other associated single nucleotide polymorphisms (SNPs) in the genomic region, was carried out on 31 postmortem-confirmed eNAD/EDM cases and 43 clinically phenotyped controls from various breeds. No significant association was found between eNAD/EDM confirmed cases and genotype at any of the four identified SNPs (P > 0.05), including the nonsynonymous variant (EquCab2.0 chr3:71,917,591; allelic P = 0.85). These findings suggest that the four SNPs, including the missense variant in the ADGRL3 region, are not associated with risk for eNAD/EDM across multiple breeds of horses

Submillimeter polarisation and magnetic field properties in the envelopes of proto-planetary nebulae CRL 618 and OH 231.8+4.2

We have carried out continuum and line polarisation observations of two Proto-planetary nebulae (PPNe), CRL 618 and OH 231.8+4.2, using the Submillimeter Array (SMA) in its compact configuration. The frequency range of observations, 330-345 GHz, includes the CO(J=3-2) line emission. CRL 618 and OH 231.8+4.2 show quadrupolar and bipolar optical lobes, respectively, surrounded by a dusty envelope reminiscent of their AGB phase. We report a detection of dust continuum polarised emission in both PPNe above 4 sigma but no molecular line polarisation detection above a 3 sigma limit. OH 231.8+4.2 is slightly more polarised on average than CRL 618 with a mean fractional polarisation of 4.3 and 0.3 per cent, respectively. This agrees with the previous finding that silicate dust shows higher polarisation than carbonaceous dust. In both objects, an anti-correlation between the fractional polarisation and the intensity is observed. Neither PPNe show a well defined toroidal equatorial field, rather the field is generally well aligned and organised along the polar direction. This is clearly seen in CRL 618 while in the case of OH 231.8+4.2, the geometry indicates an X-shaped structure coinciding overall with a dipole/polar configuration. However in the later case, the presence of a fragmented and weak toroidal field should not be discarded. Finally, in both PPNe, we observed that the well organised magnetic field is parallel with the major axis of the 12CO outflow. This alignment could indicate the presence of a magnetic outflow launching mechanism. Based on our new high resolution data we propose two scenarios to explain the evolution of the magnetic field in evolved stars.Comment: 11 pages, 8 figures and 1 table. Accepted for publication in the Monthly Notices of the Royal Astronomical Societ

A Buffer Stocks Model for Stabilizing Price of Staple Food with Considering the Expectation of Non Speculative Wholesaler

This paper is a study of price stabilization in the staple food distribution system. All stakeholders experience market risks due to some possibility causes of price volatility. Many models of price stabilization had been developed by employing several approaches such as floor-ceiling prices, buffer funds, export or import taxes, and subsidies. In the previous researches, the models were expanded to increase the purchasing price for producer and decrease the selling price for consumer. Therefore, the policy can influence the losses for non-speculative wholesaler that is reflected by the descending of selling quantity and ascending of the stocks. The objective of this model is not only to keep the expectation of both producer and consumer, but also to protect non-speculative wholesaler from the undesirable result of the stabilization policy. A nonlinear programming model was addressed to determine the instruments of intervention program. Moreover, the result shows that the wholesaler behavior affects the intervention costs. Index Terms Buffer stocks, Price stabilization, Nonlinear programming, Wholesaler behavior

Incidence and prevalence of inflammatory bowel disease in UK primary care: a population-based cohort study

OBJECTIVES: We describe temporal trends in the recorded incidence of inflammatory bowel disease (IBD) in UK primary care patients between 2000 and 2018. DESIGN: A cohort study. SETTING: The IQVIA Medical Research data (IMRD) primary care database. PARTICIPANTS: All individuals registered with general practices contributing to IMRD during the period 01 January 2000-31 December 2018. MAIN OUTCOME MEASURES: The primary outcome was the recorded diagnosis of IBD. RESULTS: 11 325 025 individuals were included and 65 700 IBD cases were identified, of which 22 560 were incident diagnoses made during the study period. Overall, there were 8077 incident cases of Crohn's disease (CD) and 12 369 incident cases of ulcerative colitis (UC). Crude incidence estimates of 'IBD overall', CD and UC were 28.6 (28.2 to 28.9), 10.2 (10.0 to 10.5) and 15.7 (15.4 to 15.9)/100 000 person years, respectively. No change in IBD incidence was observed for adults aged 17-40 years and children aged 0-9 years. However, for adults aged over 40 years, incidence fell from 37.8 (34.5 to 41.4) to 23.6 (21.3 to 26.0)/100 000 person years (average decrease 2.3% (1.9 to 2.7)/year (p<0.0001)). In adolescents aged 10-16 years, incidence rose from 13.1 (8.4 to 19.5) to 25.4 (19.5 to 32.4)/100 000 person years (average increase 3.0% (1.7 to 4.3)/year (p<0.0001)). Point prevalence estimates on 31 December 2018 for IBD overall, CD and UC were 725, 276 and 397 per 100 000 people, respectively. CONCLUSIONS: This is one of the largest studies ever undertaken to investigate trends in IBD epidemiology. Although we observed stable or falling incidence of IBD in adults, our results are consistent with some of the highest reported global incidence and prevalence rates for IBD, with a 94% rise in incidence in adolescents. Further investigation is required to understand the aetiological drivers

Electronic properties of mono-substituted tetraferrocenyl porphyrins in solution and on a gold surface: Assessment of the influencing factors for photoelectrochemical applications

Two unsymmetric meso-tetraferrocenyl-containing porphyrins of general formula Fc3(FcCOR)Por (Fc=ferrocenyl, R=CH3 or (CH2)5Br, Por=porphyrin) were prepared and characterized by a variety of spectroscopic methods, whereas their redox properties were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) approaches. The mixed-valence [Fc3(FcCOR)Por]n+ (n=1,3) were investigated using spectroelectrochemical as well as chemical oxidation methods and corroborated with density functional theory (DFT) calculations. Inter-valence charge-transfer (IVCT) transitions in [Fc3(FcCOR)Por]+ were analyzed, and the resulting data matched closely previously reported complexes and were assigned as Robin–Day class II mixed-valence compounds. Self-assembled monolayers (SAMs) of a thioacetyl derivative (Fc3(FcCO(CH2)5SCOCH3)Por) were also prepared and characterized. Photoelectrochemical properties of SAMs in different electrolyte systems were investigated by electrochemical techniques and photocurrent generation experiments, showing that the choice of electrolyte is critical for efficiency of redox-active SAMs