557 research outputs found

    Enhanced RF Behavior Multi-Layer Thermal Insulation

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    Abstract This paper shows that it is possible to exploit the modulated metasurface concept to control the unwanted coupling between antennas that are installed on the same satellite. The metasurface is combined with a Multi-Layer thermal Insulation blanket to reduce its specular reflection by spreading the energy incoherently in the surrounding space. In the design, sub-wavelength radiating elements printed on thin substrate have been used to make the metasurface response azimuthally independent, and to keep the weight of blanket down. The comparison between simulations and measurements confirms the validity of the idea

    Capitate-trapezoid synostosis: analysis of an Early Bronze Age case and review of the literature

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    Background: Carpal synostoses are congenital defects characterised by complete or incomplete coalition of two or more carpal bones. Although most of these defects are discovered only incidentally, sometimes they become clinically manifest. Among the different types of carpal coalition, the synostosis between capitate and trapezoid bones is quite rare, with only sparse data available in the literature. The aim of this report was to describe a case of capitate-trapezoid synostosis (CTS) observed in an ancient human skeleton, as well as to scrutinise the pertinent literature in order to assess for the characteristics of this type of defect, including its potential relevance to clinical practice. Materials and methods: We studied the skeletal remains of an Early Bronze Age male warrior affected by incomplete CTS. Macroscopic and radiological examination of the defect was carried out. We also performed a comprehensive PubMed search in the Medline and other specialty literature databases to retrieve and analyse data relevant to the subject under consideration. Results and Conclusions: The present case is the most ancient CTS ever found. In those literature-reported cases accompanied by careful anatomical description, such as the present one, incomplete coalition invariably occurs between the dorsal surfaces of the two bones, this characteristic emerging as a distinctive morphological trait. Literature analysis further suggests that the true prevalence of CTS is likely to be higher than estimates based on data gathered from radiology series, and that this defect may be associated with pain and carpal bossing more frequently than generally though

    LCA DI MATERIALI ISOLANTI IN CALCECANAPULO PER EDILIZIA SOSTENIBILE

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    La necessita\u300 di ridurre le emissioni derivanti dal settore dell\u2019edilizia ha portato alla ricerca di soluzioni per migliorare la sostenibilita\u300 e la performance energetica degli edifici. Una soluzione efficace e\u300 l\u2019utilizzo di mate- riali isolanti di origine naturale. Il calcecanapulo e\u300 un biocomposito ottenuto dalla miscela di una fibra natura- le (canapulo) e di un legante (calce) con ottime capacita\u300 isolanti e igrometriche. L\u2019obiettivo dello studio e\u300 quello di valutare la sostenibilita\u300 in termini di Life Cycle Assessment di tre diverse miscele del biocomposito prodotte dall\u2019azienda italiana Equilibrium: Natural Beton 200 (con un rapporto calce canapa 1:1), Natural Be- ton 300 (con rapporto 2:1) e Biomattone (2:1). L\u2019approccio dello studio e\u300 \u201cdalla culla al cancello\u201d. Per tutte le miscele la fase di produzione della calce e della canapa risultano essere quelle con impatti maggiori. Gli im- patti derivanti dal trasporto della calce possono essere ridotti cambiando il sito di approvviggionamento

    Comparison of regeneration capacity and Agrobacterium-mediated cell transformation efficiency of different cultivars and rootstocks of Vitis spp. via organogenesis.

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    The success of in vitro plant regeneration and the competence of genetic transformation greatly depends on the genotype of the species of interest. In previous work, we developed a method for the efficient Agrobacterium-mediated genetic transformation via organogenesis of V. vinifera cultivar Thompson Seedless, by using meristematic bulk (MB) as starting tissue. In this study, we applied this method for the regeneration and transformation of MBs obtained from the Italian cultivar Ciliegiolo and two of the commonly used Vitis rootstocks, 110 Richter and Kober 5BB, in comparison with Thompson Seedless. The A. tumefaciens strain EHA105, harbouring pK7WG2 binary vector, was used for the transformation trials, which allowed selection through the enhanced-green fluorescent protein (eGFP) and the neomycin phosphotransferase (nptII) gene. Putative transformed tissues and/or shoots were identified by either a screening based on the eGFP expression alone or its use in combination with kanamycin in the medium. MBs obtained from Thompson Seedless showed the highest regeneration and transformation cell competence, which subsequently allowed the recovery of stably transformed plants. Ciliegiolo, 110 Richter, and Kober 5BB, produced actively growing transgenic calli showing eGFP fluorescence, more consistently on selective media, but had no regenerative competence

    A fine physical map of the CACNA1A gene region on 19p13.1-p13.2 chromosome

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    The P/Q-type Ca(2+) channel alpha(1A) subunit gene (CACNA1A) was cloned on the short arm of chromosome 19 between the markers D19S221 and D19S179 and found to be responsible for Episodic Ataxia type 2, Familial Hemiplegic Migraine and Spinocerebellar Ataxia type 6. This region was physically mapped by 11 cosmid contigs spanning about 1. 4Mb, corresponding to less than 70% of the whole region. The cosmid contig used to characterize the CACNA1A gene accounted only for the coding region of the gene lacking, therefore, the promoter and possible regulation regions. The present study improves the physical map around and within the CACNA1A by giving a complete cosmid or BAC contig coverage of the D19S221-D19S179 interval. A number of new STSs, whether polymorphic or not, were characterized and physically mapped within this region. Four ESTs were also assigned to cosmids belonging to specific contigs

    The Role of TNFα and Sphingolipid Signaling in Cardiac Hypoxia: Evidence that Cardiomyocytes Release TNFα and Sphingosine

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    Sphingosine (SPH) is a naturally occurring signaling molecule thought to be responsible for the negative inotropic and cardiotoxic effects of the pro-inflammatory cytokine, TNFα. When subjected to hypoxia and acidosis, Langendorff perfused adult rabbit hearts generate SPH, and isolated adult rat cardiomyocytes released TNFα and SPH into the cell-conditioned media under hypoxic conditions before hypoxia-induced cell permeabilization associated with necrosis. Cardiomyocyte SPH production in response to hypoxia was blocked by TNFRII:Fc which interferes with TNFα binding to its membrane-bound receptor, suggesting that hypoxiatriggered SPH production was TNFα dependent. Extracellular SPH was rapidly converted almost exclusively to S1P by an active sphingosine kinase present in blood components, as seen in vitro and in Langendorff-perfused rat hearts. These results indicate that cardiacderived TNFα and its sphingolipid mediator, SPH, may be important extracellular signals in the heart that contribute to the pathogenesis of cardiac ischemia

    Monitoraggio biologico ed esposizione a silice: applicazione di nuovi indicatori di dose e di effetto

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    In 16 addetti alla produzione di marmi ricomposti è stato misurato Si-CAE, è stata eseguita una spirometria e sono stati dosati 8oxoGua, 8oxoGuo, 8oxodGuo, SP-A, SP-D, CC16 e HO-1. Si sono osservati valori spirometrici (FVC e FEV1) più bassi nei lavoratori rispetto ai controlli. Nei lavoratori abbiamo osservato livelli più elevati dei seguenti marcatori: Si-CAE, 8oxoGuo ed espressione di HO-1. Lo studio evidenzia che l’esposizione a silice può aumentare i livelli di Si-CAE, che può essere usato per stimare la dose al bersaglio. Infine si evidenziavano aspecifiche alterazioni spirometriche ed un aumento di biomarcatori d’effetto
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