Linear Approximations to AC Power Flow in Rectangular Coordinates

This paper explores solutions to linearized powerflow equations with bus-voltage phasors represented in rectangular coordinates. The key idea is to solve for complex-valued perturbations around a nominal voltage profile from a set of linear equations that are obtained by neglecting quadratic terms in the original nonlinear power-flow equations. We prove that for lossless networks, the voltage profile where the real part of the perturbation is suppressed satisfies active-power balance in the original nonlinear system of equations. This result motivates the development of approximate solutions that improve over conventional DC power-flow approximations, since the model includes ZIP loads. For distribution networks that only contain ZIP loads in addition to a slack bus, we recover a linear relationship between the approximate voltage profile and the constant-current component of the loads and the nodal active and reactive-power injections

Java Web Start based software for automated quantitative nuclear analysis of prostate cancer and benign prostate hyperplasia

BACKGROUND: Androgen acts via androgen receptor (AR) and accurate measurement of the levels of AR protein expression is critical for prostate research. The expression of AR in paired specimens of benign prostate and prostate cancer from 20 African and 20 Caucasian Americans was compared to demonstrate an application of this system. METHODS: A set of 200 immunopositive and 200 immunonegative nuclei were collected from the images using a macro developed in Image Pro Plus. Linear Discriminant and Logistic Regression analyses were performed on the data to generate classification coefficients. Classification coefficients render the automated image analysis software independent of the type of immunostaining or image acquisition system used. The image analysis software performs local segmentation and uses nuclear shape and size to detect prostatic epithelial nuclei. AR expression is described by (a) percentage of immunopositive nuclei; (b) percentage of immunopositive nuclear area; and (c) intensity of AR expression among immunopositive nuclei or areas. RESULTS: The percent positive nuclei and percent nuclear area were similar by race in both benign prostate hyperplasia and prostate cancer. In prostate cancer epithelial nuclei, African Americans exhibited 38% higher levels of AR immunostaining than Caucasian Americans (two sided Student's t-tests; P < 0.05). Intensity of AR immunostaining was similar between races in benign prostate. CONCLUSION: The differences measured in the intensity of AR expression in prostate cancer were consistent with previous studies. Classification coefficients are required due to non-standardized immunostaining and image collection methods across medical institutions and research laboratories and helps customize the software for the specimen under study. The availability of a free, automated system creates new opportunities for testing, evaluation and use of this image analysis system by many research groups who study nuclear protein expression

Community Transformation and Collective Healing: Lessons from Pakistan, Brazil, and Zambia

Community psychology has long sought to be global in its scope and focus, particularly having liberation as a primary and overarching goal of the field. Despite seeking to stand in solidarity with marginalized and disadvantaged persons, the field has been criticized as remaining largely western-centric in its worldview and epistemology. The historic disconnect between systems of mental health –as traditionally defined within a western context – and the experiences of marginalized and indigenous peoples around the world necessitates greater consideration of local methods of healing with greater accessibility, cultural credibility, and sustainability within local communities. In this article, the authors utilize traditional mechanisms of healing in Pakistan, Brazil, and Zambia as case studies to advocate for a community based mental health promotion model that weds: 1) prevention and health promotion; 2) professional allopathic service providers partnering with paraprofessional and traditional health practitioners; and 3) community engagement and political literacy as a transformative and empowering mental health system of care that targets the individual and the community as source and location of intervention and healing. Results are aligned with community psychology goals and intended outcomes and suggest an action-oriented model in which the community serves as actors in and agents of their own collective health and healing

Network meta-analysis-highly attractive but more methodological research is needed

Network meta-analysis, in the context of a systematic review, is a meta-analysis in which multiple treatments (that is, three or more) are being compared using both direct comparisons of interventions within randomized controlled trials and indirect comparisons across trials based on a common comparator. To ensure validity of findings from network meta-analyses, the systematic review must be designed rigorously and conducted carefully. Aspects of designing and conducting a systematic review for network meta-analysis include defining the review question, specifying eligibility criteria, searching for and selecting studies, assessing risk of bias and quality of evidence, conducting a network meta-analysis, interpreting and reporting findings. This commentary summarizes the methodologic challenges and research opportunities for network meta-analysis relevant to each aspect of the systematic review process based on discussions at a network meta-analysis methodology meeting we hosted in May 2010 at the Johns Hopkins Bloomberg School of Public Health. Since this commentary reflects the discussion at that meeting, it is not intended to provide an overview of the field

Community Transformation and Collective Healing: Lessons from Pakistan, Brazil, and Zambia

Community psychology has long sought to be global in its scope and focus, particularly having liberation as a primary and overarching goal of the field. Despite seeking to stand in solidarity with marginalized and disadvantaged persons, the field has been criticized as remaining largely western-centric in its worldview and epistemology. The historic disconnect between systems of mental health –as traditionally defined within a western context – and the experiences of marginalized and indigenous peoples around the world necessitates greater consideration of local methods of healing with greater accessibility, cultural credibility, and sustainability within local communities. In this article, the authors utilize traditional mechanisms of healing in Pakistan, Brazil, and Zambia as case studies to advocate for a community based mental health promotion model that weds: 1) prevention and health promotion; 2) professional allopathic service providers partnering with paraprofessional and traditional health practitioners; and 3) community engagement and political literacy as a transformative and empowering mental health system of care that targets the individual and the community as source and location of intervention and healing. Results are aligned with community psychology goals and intended outcomes and suggest an action-oriented model in which the community serves as actors in and agents of their own collective health and healing

Finite-element simulation of residual stresses induced by laser shock peening in TC4 samples structurally similar to a turbine blade

This study is devoted to the investigation of residual stresses distribution (RSD) in a TC4 sample treated with laser shock peening. The study placed special emphasis on analyzing the RSD at the part of the samples structurally similar to a turbine blade, which is more frequently subjected to damage during service according to the aircraft statistics. Results of simulation showed that low power density of 1.11 GWt/cm2 could not induce compressive residual stress on the surface of a treated object. Furthermore, increasing the overlapping of laser spots does not improve the situation and still fail to induce surface compressive residual stress at a laser intensity of 1.11&nbsp;GWt/cm2. The compressive stresses occur only with the rise in power density. Reducing the spot size from 3 mm to 1 mm for the power density of 10 GWt/cm2 results in a 20% increase in the magnitude of compressive residual stress in the area of interest. Moreover, applying 35% overlapping further enhances this value. In addition to increasing the magnitude of residual stress, this approach also leads to a more homogeneous RSD of the treated material

The role of China in the global spread of the current cholera pandemic

Epidemics and pandemics of cholera, a severe diarrheal disease, have occurred since the early 19th century and waves of epidemic disease continue today. Cholera epidemics are caused by individual, genetically monomorphic lineages of Vibrio cholerae: the ongoing seventh pandemic, which has spread globally since 1961, is associated with lineage L2 of biotype El Tor. Previous genomic studies of the epidemiology of the seventh pandemic identified three successive sub-lineages within L2, designated waves 1 to 3, which spread globally from the Bay of Bengal on multiple occasions. However, these studies did not include samples from China, which also experienced multiple epidemics of cholera in recent decades. We sequenced the genomes of 71 strains isolated in China between 1961 and 2010, as well as eight from other sources, and compared them with 181 published genomes. The results indicated that outbreaks in China between 1960 and 1990 were associated with wave 1 whereas later outbreaks were associated with wave 2. However, the previously defined waves overlapped temporally, and are an inadequate representation of the shape of the global genealogy. We therefore suggest replacing them by a series of tightly delineated clades. Between 1960 and 1990 multiple such clades were imported into China, underwent further microevolution there and then spread to other countries. China was thus both a sink and source during the pandemic spread of V. cholerae, and needs to be included in reconstructions of the global patterns of spread of cholera

Satellite Imagery in the Study and Forecast of Malaria

More than 30 years ago, human beings looked back from the Moon to see the magnificent spectacle of Earthrise. The technology that put us into space has since been used to assess the damage we are doing to our natural environment and is now being harnessed to monitor and predict diseases through space and time. Satellite sensor data promise the development of early-warning systems for diseases such as malaria, which kills between 1 and 2 million people each year