The initiation and progression of late-life romantic relationships

This research explores the initiation and progression of new late-life romantic relationships among older Australians (60 years plus). Our research found that older adult romantic relationships were meaningful, important and sexually intimate. However, few led to cohabitation or marriage, with these older adults preferring to date or to maintain separate households (living-apart- together, LAT). In line with Giddens’ ideal of ‘pure’ relationships, our research indicates that older adults are looking for egalitarian relationships based on emotional and sexual equality, albeit not necessarily based on cohabitation or monogamy

Love actually! Older adults and their romantic internet relationships

This research was inspired by two stereotypes: first, that older adults don?t do computers ? and certainly not the Internet and, secondly, that older adults don?t do sex ? they are asexual. The results clearly show these stereotypes to be flawed. Semi-structured qualitative interviews were conducted via synchronous computer-mediated-communication (private chat). The sample consisted of older adults (61 ? 85 years) who had all used the Internet to meet potential romantic partners, either through their involvement in online discussion groups or via online dating sites. For the most part, the relationships described were meaningful, intimate and long-lasting. The majority were involved in ongoing sexual activity with their partners, and for some, cyber-sex was or had been an integral part of their relationships. Additionally, a proportion enjoyed flirting online with others and some were also involved in extra-dyadic relationships; indicating that sex and intimacy outside of primary, committed relationships was just as compelling an activity for these older adults as for younger Internet users

The impact of experiences of ageism on sexual activity and interest in later life

Experiences of ageism are associated with poorer health outcomes. Sexual activity and interest are areas in life where the impact of ageism may also be evident as popular culture often depicts the older body as asexual, undesirable or sexually impotent. We explore the possible links between experiences of ageism and sexual activity/interest in later life using data from a study of Australians aged 60+. We explored characteristics of those who were more likely to have experienced ageism (measured using the Ageism survey) and the relationships between experiences of ageism and measures of sexual interest/activity in later life (n=1,817). Experiences of ageism were greater among those without a partner, unemployed participants, those with lower incomes, and poorer self-rated health. Adjusting for these differences, experiences of ageism were more likely to be reported by those who had not had sex in the past two years and were not sure about their hopes/plans for sex in the future. Those who reported their sexual interest had increased or decreased since 60 also reported greater levels of ageism experience, as did those who wanted to have sex more frequently in the future. Ageism appears to impact sexual activity and interest in different ways. It is critical that social policy aims to reverse attitudes that reinforce the view of the ageist asexual and unattractive older body or person

Promoting Independence Through quality dementia Care at Home (PITCH): a research protocol for a stepped-wedge cluster-randomised controlled trial

BACKGROUND: Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evaluates a training programme delivered to care staff (paid personal carers) of clients living with dementia at home. METHODS: This study is a pragmatic stepped-wedge cluster-randomised controlled trial (SW-CRT). Home care workers (HCWs) from seven home care service providers are grouped into 18 geographical clusters. Clusters are randomly assigned to intervention or control groups. The intervention group receives 7 h of a dementia education and upskilling programme (Promoting Independence Through quality dementia Care at Home [PITCH]) after baseline measures. The control group receives PITCH training 6 months after baseline measures. This approach will ensure that all participants are offered the program. Home care clients living with dementia are also invited to participate, as well as their family carers. The primary outcome measure is HCWs’ sense of competence in dementia care provision. DISCUSSION: Upskilling home care staff is needed to support the increasing numbers of people living with dementia who choose to remain at home. This study uses a stepped-wedge cluster-randomised trial to evaluate a training programme (PITCH) for dementia care that is delivered to front-line HCWs. TRIAL REGISTRATION: anzctr.org.au; ACTRN12619000251123. Registered on 20 February 2019

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.

Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one-class logistic regression (OCLR) machine-learning algorithm to extract transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. Using OCLR, we were able to identify previously undiscovered biological mechanisms associated with the dedifferentiated oncogenic state. Analyses of the tumor microenvironment revealed unanticipated correlation of cancer stemness with immune checkpoint expression and infiltrating immune cells. We found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors. Application of our stemness indices to single-cell data revealed patterns of intra-tumor molecular heterogeneity. Finally, the indices allowed for the identification of novel targets and possible targeted therapies aimed at tumor differentiation

Technophobic and asexual? I don't think so! Older Adults and their Online Romantic Relationships (ISR Lunchtime Seminar Series)

This paper is drawn from a qualitative study involving 50 older adults (60-92 years of age) and their online and offline romantic relationships. This presentation details the results of the online romance group, consisting of 32 Australian participants. I discuss the development of these romantic relationships, including their transition from online to offline, their longevity and their progression to sexual intimacy. It is argued that the Internet provides a unique opportunity for older adults to connect with like-minded others - providing unprecedented access to far larger numbers of possible partners than in their offline lives. Some insight into participant behaviours and attitudes towards cyber-sex and cyber-cheating are also provided. This seminar presented as part of the Institute for Social Research lunchtime seminar series for 2009

Age shall not weary them of pleasure

Meet Katherine. She loves the internet. She has been using it for over 13 years and is on it for more than four hours every day. She uses it mainly for research and email and, of course, instant messaging, where she keeps in touch with her partner of 10 years, John. They use the internet as a means of staying connected and, on occasion, for engaging in cyber-sex, which she describes as 'fun'. When they first met face to face, Katherine said they couldn't keep their hands off each other. Sound familiar? You bet! Recent research has shown that almost 30 million people in America know someone who has been in a long-term relationship or has married someone they met online, and over 63 million know someone who has used an online dating site. [Introduction

Using online methods to interview older adults about their romantic and sexual relationships

Abstract not available