838 research outputs found
The fluid dynamics of swimming by jumping in copepods
Author Posting. © The Authors, 2010. This is the author's version of the work. It is posted here by permission of Royal Society for personal use, not for redistribution. The definitive version was published in Journal of the Royal Society Interface 8 (2011): 1090-1103, doi:10.1098/rsif.2010.0481.Copepods swim either continuously by vibrating their feeding appendages or erratically
by repeatedly beating their swimming legs resulting in a series of small jumps. The two
swimming modes generate different hydrodynamic disturbances and therefore expose the
swimmers differently to rheotactic predators. We developed an impulsive stresslet model to
quantify the jump-imposed flow disturbance. The predicted flow consists of two counterrotating
viscous vortex rings of similar intensity, one in the wake and one around the body of
the copepod. We showed that the entire jumping flow is spatially limited and temporally
ephemeral owing to jump-impulsiveness and viscous decay. In contrast, continuous steady
swimming generates two well-extended long-lasting momentum jets both in front of and
behind the swimmer, as suggested by the well-known steady stresslet model. Based on the
observed jump-swimming kinematics of a small copepod Oithona davisae, we further
showed that jump-swimming produces a hydrodynamic disturbance with much smaller
spatial extension and shorter temporal duration than that produced by a same-size copepod
cruising steadily at the same average translating velocity. Hence, small copepods in jumpswimming
are much less detectable by rheotactic predators. The present impulsive stresslet
model improves a previously published impulsive Stokeslet model that applies only to the
wake vortex.This work was supported by National Science Foundation grants NSF OCE-0352284 &
IOS-0718506 and an award from WHOI’s Ocean Life Institute to H.J and by grants from the
Danish Research Council for independent research and the Niels Bohr Foundation to T.K
Ion holes in the hydrodynamic regime in ultracold neutral plasmas
We describe the creation of localized density perturbations, or ion holes, in an ultracold neutral
plasma in the hydrodynamic regime, and show that the holes propagate at the local ion acoustic wave
speed. We also observe the process of hole splitting, which results from the formation of a density
depletion initially at rest in the plasma. One-dimensional, two-fluid hydrodynamic simulations
describe the results well. Measurements of the ion velocity distribution also show the effects of the
ion hole and confirm the hydrodynamic conditions in the plasma
Thirty-five year mortality following receipt of SV40- contaminated polio vaccine during the neonatal period
Early poliovirus vaccines, both inactivated and live attenuated, were inadvertently contaminated with simian virus 40 (SV40), a monkey virus known to be oncogenic for newborn hamsters. Although large epidemiologic studies have not identified an elevated cancer risk in persons who received SV40-contaminated vaccines, fragments of SV40 DNA have recently been identified in certain human tumours. We report the follow-up of a cohort of 1073 persons, unique because they received SV40-contaminated poliovirus vaccines as newborns in 1961–63. A previous report of the status of these subjects as of 1977–79 identified 15 deaths, none due to cancer. The present study utilized the National Death Index to identify deaths in the cohort for the years 1979–96. Expected deaths were calculated from Cleveland area sex-, age-, race- and year-specific mortality rates. Increased mortality from all causes was not found. 4 deaths from cancer were found compared to 3.16 expected (P= 0.77). However, 2 deaths from testicular cancer occurred, compared to 0.05 expected (P= 0.002), which may be a chance finding due to multiple comparisons. There were 2 deaths due to leukaemia, a non-significant finding, and no deaths due to tumours of the types putatively associated with SV40. Although these results are, for the most part, consistent with other negative epidemiologic investigations of risks from SV40-contaminated vaccines, further study of testicular cancer may be warranted, and it will be important to continue monitoring this cohort which is now reaching middle-age. © 2001 Cancer Research Campaig
Turbulent Friction in Rough Pipes and the Energy Spectrum of the Phenomenological Theory
The classical experiments on turbulent friction in rough pipes were performed
by J. Nikuradse in the 1930's. Seventy years later, they continue to defy
theory. Here we model Nikuradse's experiments using the phenomenological theory
of Kolmog\'orov, a theory that is widely thought to be applicable only to
highly idealized flows. Our results include both the empirical scalings of
Blasius and Strickler, and are otherwise in minute qualitative agreement with
the experiments; they suggest that the phenomenological theory may be relevant
to other flows of practical interest; and they unveil the existence of close
ties between two milestones of experimental and theoretical turbulence.Comment: Accepted for publication in PRL; 4 pages, 4 figures; revised versio
Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study
Resilience in Virginia: Outlook 2021
VCPC\u27s October webinar included an update on Virginia’s participation in the Regional Greenhouse Gas Initiative and the implementation of Executive Order 24; remarks from the Speaker of the House of Delegates, Eileen Filler -Corn, and a legislative panel discussed resilience issues for the upcoming 2021 Virginia General Assembly session. VCPC was honored to host Governor Ralph Northam for Closing Remarks
Resilience in Virginia: Outlook 2021
VCPC\u27s October webinar included an update on Virginia’s participation in the Regional Greenhouse Gas Initiative and the implementation of Executive Order 24; remarks from the Speaker of the House of Delegates, Eileen Filler -Corn, and a legislative panel discussed resilience issues for the upcoming 2021 Virginia General Assembly session. VCPC was honored to host Governor Ralph Northam for Closing Remarks
Systematically Variable Planktonic Carbon Metabolism Along a Land-To-Lake Gradient in a Great Lakes Coastal Zone
During the summers of 2002–2013, we measured rates of carbon metabolism in surface waters of six sites across a land-to-lake gradient from the upstream end of drowned river-mouth Muskegon Lake (ML) (freshwater estuary) to 19 km offshore in Lake Michigan (LM) (a Great Lake). Despite considerable inter-year variability, the average rates of gross production (GP), respiration (R) and net production (NP) across ML (604 ± 58, 222 ± 22 and 381 ± 52 µg C L−1 day−1, respectively) decreased steeply in the furthest offshore LM site (22 ± 3, 55 ± 17 and −33 ± 15 µg C L−1day−1, respectively). Along this land-to-lake gradient, GP decreased by 96 ± 1%, whereas R only decreased by 75 ± 9%, variably influencing the carbon balance along this coastal zone. All ML sites were consistently net autotrophic (mean GP:R = 2.7), while the furthest offshore LM site was net heterotrophic (mean GP:R = 0.4). Our study suggests that pelagic waters of this Great Lakes coastal estuary are net carbon sinks that transition into net carbon sources offshore. Reactive and dynamic estuarine coastal zones everywhere may contribute similarly to regional and global carbon cycles
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Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women
IGF-I shares structural homology and in vitro metabolic activity with insulin. Laboratory models suggest that IGF-I and its binding proteins IGFBP-1 and IGFBP-2 have potentially beneficial effects on diabetes risk, whereas IGFBP-3 may have adverse effects. We therefore conducted a prospective nested case-control investigation of incident diabetes (n = 742 case subjects matched 1:1 to control subjects) and its associations with IGF-axis protein levels in the Nurses’ Health Study, a cohort of middle-aged women. The median time to diabetes was 9 years. Statistical analyses were adjusted for multiple risk factors, including insulin and C-reactive protein. Diabetes risk was fivefold lower among women with baseline IGFBP-2 levels in the top versus bottom quintile (odds ratio [OR]q5–q1 = 0.17 [95% CI 0.08–0.35]; P trend < 0.0001) and was also negatively associated with IGFBP-1 levels (ORq5–q1 = 0.37 [0.18–0.73]; P trend = 0.0009). IGFBP-3 was positively associated with diabetes (ORq5–q1 = 2.05 [1.20–3.51]; P trend = 0.002). Diabetes was not associated with total IGF-I levels, but free IGF-I and diabetes had a significant association that varied (P interaction = 0.003) by insulin levels above the median (ORq5–q1 = 0.48 [0.26–0.90]; P trend = 0.0001) versus below the median (ORq5–q1 = 2.52 [1.05–6.06]; P trend < 0.05). Thus, this prospective study found strong associations of incident diabetes with baseline levels of three IGFBPs and free IGF-I, consistent with hypotheses that the IGF axis might influence diabetes risk
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