Developing a Metrics Framework for the Federal Government in Computer Security Incident Response

As technology advances and society becomes more dependent on information technology (IT), the exposure to vulnerabilities and threats increases. These threats pertain to industry as well as government information systems. There is, however, a lack in how we measure the performance and create accountability for computer security incident response (CSIR) capabilities. Many government organizations still struggle to determine what security metrics to use and how to find value within these metrics. To fill this apparent gap, a metrics framework has been developed for incident response to serve as an internal analysis, supporting continuous improvement in incident reporting and strengthening the security posture for an organization’s mission. The goal of this metrics framework for CSIR aims to provide a holistic approach towards security metrics, which is specific to incident reporting and promotes efforts of more practical and clear guidelines on measuring the computer security incident response team (CSIRT). An additional benefit to this project is that it provides middle management with a framework for measuring the results of incident reporting in a CSIR program

Web Design: Elements of Effective Communication

The rapid evolution of information technology over the past several decades has opened many new and unique modes of communication. Clearly, the web is one such technology. However, it is quite possible that a fascination with the technology per se can hinder participants from one of its main functions— effective communication. The following essay explores a return to the basics of designing an effective web-based communication strategy. The key components of this strategy are: 1) consistent look and feel, 2) conceptual consistency, and 3) positive attention

A framework for information management: Evolution of the new manager

This article provides & framework for the information management field and of the evolution of the new manager of the future. It reviews the key changes in our modern society and how the computer has become a new tool. It presents a new definition of information management and then gives a short explanation of the framework areas

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.

Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and function. Given the worldwide aging demographics, this is a major contributor to morbidity, escalating socio-economic costs and ultimately mortality. Previously, it has been established that a decrease in regenerative capacity in addition to SkM loss with age coincides with suppression of insulin/insulin-like growth factor signalling pathways. However, genetic or pharmacological modulations of these highly conserved pathways have been observed to significantly enhance life and healthspan in various species, including mammals. This therefore provides a controversial paradigm in which reduced regenerative capacity of skeletal muscle tissue with age potentially promotes longevity of the organism. This paradox will be assessed and considered in the light of the following: (i) the genetic knockout, overexpression and pharmacological models that induce lifespan extension (e.g. IRS-1/s6K KO, mTOR inhibition) versus the important role of these signalling pathways in SkM growth and adaptation; (ii) the role of the sirtuins (SIRTs) in longevity versus their emerging role in SkM regeneration and survival under catabolic stress; (iii) the role of dietary restriction and its impact on longevity versus skeletal muscle mass regulation; (iv) the crosstalk between cellular energy metabolism (AMPK/TSC2/SIRT1) and survival (FOXO) versus growth and repair of SkM (e.g. AMPK vs. mTOR); and (v) the impact of protein feeding in combination with dietary restriction will be discussed as a potential intervention to maintain SkM mass while increasing longevity and enabling healthy aging

Communication and trust in the bounded confidence model

The communication process in a situation of emergency is discussed within the Scheff theory of shame and pride. The communication involves messages from media and from other persons. Three strategies are considered: selfish (to contact friends), collective (to join other people) and passive (to do nothing). We show that the pure selfish strategy cannot be evolutionarily stable. The main result is that the community structure is statistically meaningful only if the interpersonal communication is weak.Comment: 6 pages, 5 figures, RevTeX, for ICCCI-201

NOx and O3 above a tropical rainforest: an analysis with a global and box model

A cross-platform field campaign, OP3, was conducted in the state of Sabah in Malaysian Borneo between April and July of 2008. Among the suite of observations recorded, the campaign included measurements of NOx and O3 – crucial outputs of any model chemistry mechanism. We describe the measurements of these species made from both the ground site and aircraft. We then use the output from two resolutions of the chemistry transport model p-TOMCAT to illustrate the ability of a global model chemical mechanism to capture the chemistry at the rainforest site. The basic model performance is good for NOx and poor for ozone. A box model containing the same chemical mechanism is used to explore the results of the global model in more depth and make comparisons between the two. Without some parameterization of the nighttime boundary layer – free troposphere mixing (i.e. the use of a dilution parameter), the box model does not reproduce the observations, pointing to the importance of adequately representing physical processes for comparisons with surface measurements. We conclude with a discussion of box model budget calculations of chemical reaction fluxes, deposition and mixing, and compare these results to output from p-TOMCAT. These show the same chemical mechanism behaves similarly in both models, but that emissions and advection play particularly strong roles in influencing the comparison to surface measurements

Semiclassical Theory of Coulomb Blockade Peak Heights in Chaotic Quantum Dots

We develop a semiclassical theory of Coulomb blockade peak heights in chaotic quantum dots. Using Berry's conjecture, we calculate the peak height distributions and the correlation functions. We demonstrate that the corrections to the corresponding results of the standard statistical theory are non-universal and can be expressed in terms of the classical periodic orbits of the dot that are well coupled to the leads. The main effect is an oscillatory dependence of the peak heights on any parameter which is varied; it is substantial for both symmetric and asymmetric lead placement. Surprisingly, these dynamical effects do not influence the full distribution of peak heights, but are clearly seen in the correlation function or power spectrum. For non-zero temperature, the correlation function obtained theoretically is in good agreement with that measured experimentally.Comment: 5 color eps figure

HOx observations over West Africa during AMMA: impact of isoprene and NOx

Aircraft OH and HO2 measurements made over West Africa during the AMMA field campaign in summer 2006 have been investigated using a box model constrained to observations of long-lived species and physical parameters. "Good" agreement was found for HO2 (modelled to observed gradient of 1.23 ± 0.11). However, the model significantly overpredicts OH concentrations. The reasons for this are not clear, but may reflect instrumental instabilities affecting the OH measurements. Within the model, HOx concentrations in West Africa are controlled by relatively simple photochemistry, with production dominated by ozone photolysis and reaction of O(1D) with water vapour, and loss processes dominated by HO2 + HO2 and HO2 + RO2. Isoprene chemistry was found to influence forested regions. In contrast to several recent field studies in very low NOx and high isoprene environments, we do not observe any dependence of model success for HO2 on isoprene and attribute this to efficient recycling of HOx through RO2 + NO reactions under the moderate NOx concentrations (5–300 ppt NO in the boundary layer, median 76 ppt) encountered during AMMA. This suggests that some of the problems with understanding the impact of isoprene on atmospheric composition may be limited to the extreme low range of NOx concentrations

Targeting the Ataxia Telangiectasia Mutated-null Phenotype in Chronic Lymphocytic Leukemia with Pro-oxidants

Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to target Ataxia Telangiectasia Mutated-deficient chronic lymphocytic leukemia. As Ataxia Telangiectasia Mutated has been implicated in redox homeostasis, we investigated the effect of the Ataxia Telangiectasia Mutated-null chronic lymphocytic leukemia genotype on cellular responses to oxidative stress with a view to therapeutic targeting. We found that in comparison to Ataxia Telangiectasia Mutated-wild type chronic lymphocytic leukemia, pro-oxidant treatment of Ataxia Telangiectasia Mutated-null cells led to reduced binding of NF-E2 p45-related factor-2 to antioxidant response elements and thus decreased expression of target genes. Furthermore, Ataxia Telangiectasia Mutated-null chronic lymphocytic leukemia cells contained lower levels of antioxidants and elevated mitochondrial reactive oxygen species. Consequently, Ataxia Telangiectasia Mutated-null chronic lymphocytic leukemia, but not tumours with 11q deletion or TP53 mutations, exhibited differentially increased sensitivity to pro-oxidants both in vitro and in vivo. We found that cell death was mediated by a p53- and caspase-independent mechanism associated with apoptosis inducing factor activity. Together, these data suggest that defective redox-homeostasis represents an attractive therapeutic target for Ataxia Telangiectasia Mutated-null chronic lymphocytic leukemia

Influence of exercise intensity on the tendon mechanical properties of older individuals.

Approximately one-third of people aged over 65 fall at least once a year and about half of these do so recurrently. The ability to maintain balance or stability has previously been associated with lower limb tendon structural and mechanical properties, with stiffer tendon structures associated with increased balance ability (Onambele et al., 2006: Journal of Applied Physiology, 100, 2048–2056). Increased tendon compliance is not an irreversible ageing effect. It has been shown that following 14 weeks high intensity resistance training (~80% one repetition maximum (1RM)), tendon stiffness was increased in an elderly population (Reeves et al., 2003: Journal of Physiology, 548, 971–981). However, the majority of resistance exercise prescribed for an elderly population is of lower intensity than 80% 1RM. It is possible that this lower intensity resistance exercise does not produce the required stimulus for tendon adaptation