Analysis of X-ray flares in GRBs

We present a detailed study of the spectral and temporal properties of the X-ray flares emission of several GRBs. We select a sample of GRBs which X-ray light curve exhibits large amplitude variations with several rebrightenings superposed on the underlying three-segment broken powerlaw that is often seen in Swift GRBs. We try to understand the origin of these fluctuations giving some diagnostic in order to discriminate between refreshed shocks and late internal shocks. For some bursts our time-resolved spectral analysis supports the interpretation of a long-lived central engine, with rebrightenings consistent with energy injection in refreshed shocks as slower shells generated in the central engine prompt phase catch up with the afterglow shock at later times.Comment: 9 pages, 3 figures. Invited talk at the Swift-Venice 2006 meeting to be published by "Il Nuovo Cimento

Boundary spanning and gatekeeping roles of UK audit committees

Post-financial crisis, audit committee (AC) reforms are proposed to improve the quality of financial reporting.†† The editorial process for this paper was undertaken by Pauline Weetman, former ABR editor. This paper's empirical contribution is to investigate the extent to which ACs and audit committee chairs (ACCs) engage with chief financial officers (CFOs) and audit partners (APs) across a range of 32 financial reporting issues. It is the first large-scale survey of interactions to move beyond the micro-CFO/AP dyad and to distinguish the individual ACC from the AC group. While 37% of the 5445 reported discussions involve all three key individuals together with the full AC, 35% involve neither the AC nor the ACC and the ACC acts without the full AC in a significant minority of cases. The parties reported to be involved are similar across the three respondent groups but vary with financial reporting issue, company size and audit firm size. The paper's theoretical contribution is to interpret the evidence using the concepts of boundary spanning and gatekeeping roles. The research reveals incomplete levels of AC and ACC engagement with financial reporting issues. Findings have implications for policy-makers regarding the role, influence and effectiveness of the AC in financial reporting matters. Directions for future research are identified

The framing and fashioning of therapeutic citizenship among people living with HIV taking Antiretroviral Therapy in Uganda

In this article, we examine how people living with HIV (PLWH) were able to reconceptualize or “reframe” their understanding of HIV and enhance their capacity to self-manage the condition. Two in-depth interviews were held with 38 PLWH (20 women, 18 men) selected from three government and nongovernment antiretroviral therapy (ART) delivery sites in Wakiso District, and the narratives analyzed. ART providers played an important role in shaping participants’ HIV self-management processes. Health workers helped PLWH realize that they could control their condition, provided useful concepts and language for emotional coping, and gave advice about practical self-management tasks, although this could not always be put into practice. ART providers in this setting were spaces for the development of a collective identity and a particular form of therapeutic citizenship that encouraged self-management, including adherence to ART. Positive framing institutions are important for many PLWH in resource-limited settings and the success of ART programs

Smallanthus sonchifolius (Yacon) leaves: an emerging source of compounds for diabetes management

Diabetes mellitus is a chronic metabolic disease that develops mainly due to insulin deficiency or resistance to insulin action. All forms of diabetes are characterized by chronic hyperglycemia, which has an important role in the pathogenesis of diabetic complications. Leaves of Smallanthus sonchifolius (Poepp.&Endl.) H. Robinson (yacon) have been used since ancient times to prepare medicinal herbal tea with beneficial health properties. This review aims to discuss some key aspects related to the potential use of S. sonchifolius leaves and their natural biomolecules for the prophylaxis and treatment of diabetes as well as the potential mechanisms of action.Fil: Honore, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentin

Extracellular matrix remodeling and TGF-β1/Smad signaling in diabetic colon mucosa

Diabetes is associated with metabolic and functional alterations in the gut. Using an experimental model of streptozotocin (STZ)-induced diabetes in rodents, we analyzed the extracellular matrix (ECM) and TGF-β/Smad signaling in the colon mucosa. Male rats were divided into normal control, diabetic and insulin treated diabetic groups during 4 and 9 weeks. Sirius red staining showed marked increase in the extracellular matrix deposition in diabetic mucosa. High levels of fibrillar collagen (I and III) and fibronectin mRNAs were also detected with an imbalance between MMPs/TIMPs activities. Moreover, an increased mesenchymal cell proliferation together with an enhanced expression of myofibroblasts markers vimentin and α-SMA were observed. TGF-β/Smad signaling-related genes were determined using RT-PCR, Western blotting, and immunohistochemistry. Diabetic rats showed a significant up-regulation of TGF-β1, TGF-β receptors and the effectors p-Smad2/3 in the mucosa compared with control rats. Insulin treatment attenuated the stimulating effect of diabetes on colon ECM deposition and TGF-β/Smad signaling. In conclusion, the overall results showed a deregulation of the TGFβ1 pathway associated with the appearance of myofibroblasts and the accumulation of ECM in the mucosa of diabetic colon. These data provide the first in vivo evidence that TGF-β1/Smad is a key component of intestinal tissue remodeling in diabetes.Fil: D'arpino, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Fuchs, Alicia Graciela. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Honore, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentin

The Unusual Universality of Branching Interfaces in Random Media

We study the criticality of a Potts interface by introducing a {\it froth} model which, unlike its SOS Ising counterpart, incorporates bubbles of different phases. The interface is fractal at the phase transition of a pure system. However, a position space approximation suggests that the probability of loop formation vanishes marginally at a transition dominated by {\it strong random bond disorder}. This implies a linear critical interface, and provides a mechanism for the conjectured equivalence of critical random Potts and Ising models.Comment: REVTEX, 13 pages, 3 Postscript figures appended using uufile

Spot size measurements in the Eli-NP compton gamma source

A high brightness electron Linac is being built in the Compton Gamma Source at the ELI Nuclear Physics facility in Romania. To achieve the design luminosity, a train of 32 bunches with a nominal charge of 250 pC and 16 ns spacing , will collide with the laser beam in the interaction point. Electron beam spot size is measured with an OTR (optical transition radiation) profile moni-tors. In order to measure the beam properties, the optical radiation detecting system must have the necessary accu-racy and resolution. This paper deals with the studies of different optic configurations to achieve the magnifica-tion, resolution and accuracy desired considering design and technological constraints; we will compare several configurations of the optical detection line to justify the one chosen for the implementation in the Lina

A gamma ray burst with small contamination

We present a scenario (SupraNova) for the formation of GRBs occurring when a supramassive neutron star (SMNS) loses so much angular momentum that centrifugal support against self--gravity becomes impossible, and the star implodes to a black hole. This may be the baryon--cleanest environment proposed so far, because the SN explosion in which the SMNS formed swept the medium surrounding the remnant, and the quickly spinning remnant loses energy through magnetic dipole radiation at a rate exceeding its Eddington luminosity by some four orders of magnitude. The implosion is adiabatic because neutrinos have short mean free paths, and silent, given the prompt collapse of the polar caps. However, a mass ~ 0.1 M_solar in the equatorial belt can easily reach centrifugal equilibrium. The mechanism of energy extraction is via the conversion of the Poynting flux (due to the large--scale magnetic field locked into the minitorus) into a magnetized relativistic wind. Occasionally this model will produce quickly decaying, or non--detectable afterglows.Comment: To appear in The Astrophysical Journal Letters. AASTeX LateX, no figure

Universal features of electron-phonon interactions in atomic wires

The effect of electron-phonon interactions in the conductance through metallic atomic wires is theoretically analyzed. The proposed model allows to consider an atomic size region electrically and mechanically coupled to bulk electrodes. We show that under rather general conditions the features due to electron-phonon coupling are described by universal functions of the system transmission coefficients. It is predicted that the reduction of the conductance due to electron-phonon coupling which is observed close to perfect transmission should evolve into an enhancement at low transmission. This crossover can be understood in a transparent way as arising from the competition between elastic and inelastic processes.Comment: 5 pages, 5 figure