Bovine Tuberculosis Prevalence Survey on Cattle in the Rural Livestock System of Torodi (Niger)

BACKGROUND: Bovine tuberculosis (BTB) is a widespread zoonosis in developing countries but has received little attention in sub-Saharan Africa, especially in Niger. Recent investigations confirmed the high incidence of the disease in cattle slaughtered in an abattoir in Niamey. The fact that most of the animals in which M. bovis has been identified were from the rural area of Torodi implied the existence of a probable source of BTB in this region. This study aimed to determine the prevalence of BTB infection in cattle and to identify risk factors for infection in human and cattle populations in Torodi. METHODS AND PRINCIPAL FINDINGS: A survey was carried out at the level of households keeping livestock (n = 51). The questionnaire was related to the potential risk factors and the presence of clinical signs of TB both in animals and humans. Comparative Intradermal Tuberculin Test was conducted to determine the TB status in cattle (n = 393). The overall apparent individual animal prevalence of tuberculin reactors was 3.6% (CI: 95%, 1.9-5.9), whereas the individual true prevalence was estimated at 0.8% (CI: 95%, 0.0-5.0). Using a multivariate logistic regression analysis and a classification tree analysis, the only household level risk factor that significantly influenced the presence of BTB in cattle was the presence of animals coughing in the herd (OR = 4.7, 95% CI: 1.12-19.71, p-value = 0.034). The lack of the practice of quarantine was borderline significant (OR = 4.2, 95% CI: 0.96-18.40, p-value = 0.056). CONCLUSION/SIGNIFICANCE: The study confirmed that BTB is endemic in cattle in Torodi and the risk of the transmission of the disease to humans is potentially high. For the control of the disease in livestock, slaughtering of infected animals and the compensation of the owners is needed. Collaboration between the veterinary and the medical sectors, in the diagnosis, monitoring, prevention and control of BTB is strongly encouraged

Management of hyperthyroidism due to Graves' disease: frequently asked questions and answers (if any)

Graves\u2019 disease is the most common cause of hyperthyroidism in iodine-replete areas. Although progress has been made in our understanding of the pathogenesis of the disease, no treatment targeting pathogenic mechanisms of the disease is presently available. Therapies for Graves\u2019 hyperthyroidism are largely imperfect because they are bound to either a high rate of relapsing hyperthyroidism (antithyroid drugs) or lifelong hypothyroidism (radioiodine treatment or thyroidectomy). Aim of the present article is to offer a practical guidance to the reader by providing evidence-based answers to frequently asked questions in clinical practice

Global change and investments in smallholder irrigation for food and nutrition security in Sub-Saharan Africa

Investments in irrigation contribute to poverty reduction and enhance food security. This paper considers irrigation investments more broadly in the context of rural–urban linkages and thus examines rural irrigation schemes and peri-urban and urban agriculture using freshwater, groundwater and wastewater. We present case studies from East, West and Southern Africa, while focusing on the imperative of smallholders and of food security and nutrition. Evidence from Big Data and telecoupling show that, amid global change and sustainability issues, irrigation development strengthens connections between humans and nature with notable benefits to food security. Transforming investments to feed the future generation require priority investments in irrigation, solar energy for groundwater pumping, groundwater development policy, and integration of peri-urban and urban agriculture into food systems. Equally important will be no-regret interventions in wastewater reuse, water storage and groundwater buffer, micro-irrigation, and wholesale reconfiguration of farming systems, through anticipatory investments, to safeguard food security and sustainability into the distant future