Determinan Pola Konsumsi Dharuriyyah, Hajiyyah dan Tahsiniyyah (Studi Kasus Pengguna Marketplace di Kota Malang)

The advancement of technology in the era of digitalization offers convenience to consumers for quick and easy shopping through digital platforms such as marketplaces. Marketplaces provide various products and services, ranging from basic needs to luxury items. This convenience creates new opportunities and challenges in understanding consumer behavior, especially in terms of how a consumer's consumption patterns correspond with Islamic values in the context of meeting their needs. This research aims to analyze the determinants or factors influencing the consumption patterns of a Muslim consumer in meeting various levels of needs, such as financial literacy, hedonic motivation, technological proficiency, and price discounts. A case study was conducted on marketplace users in Malang City using a quantitative method and multiple linear regression analysis. The research results indicate that a consumer's financial literacy and technological proficiency, as well as the presence of price discounts, have an effect on their consumption patterns at the dharuriyyah, hajiyyah, and tahsiniyyah levels of need. However, hedonic motivation does not affect consumption patterns at all levels of needs. By understanding the effect of these factors on consumption patterns, this research offers valuable insights into how consumers perceive and prioritize their various needs in the ever-evolving digital environment

PIKIRAN DAMAI BERDASARKAN PITUTUR MARKESOT: MODAL REMAJA UNTUK MEMINIMALISIR PERILAKU AGRESI

Fenomena perilaku agresi sampai saat ini masih ditunjukkan oleh remaja. Salah satu cara untuk menghindarkan remaja untuk berperilaku agresi adalah dengan menamankan pikiran damai. Ketika remaja mempunyai pikiran damai, maka kekerasan, tawuran, pemerkosaan, dan pembunuhan akan berkurang dan terciptalah perdamaian di dunia remaja. Banyak cara untuk menamkan pemikiran damai kepada remaja saat ini, salah satunya melalui internalisasi pitutur tokoh Markesot. Karya tulis ilmiah ini merupakan penelitian kualitatif dengan jenis Hermeneutika. Penelitian ini adalah metode atau cara menafsirkan simbol berupa teks atau sesuatu yang di perlakukan sebagai teks untuk di cari arti dan maknanya. Teks yang di tafsirkan dalam penelitian ini berupa teks karya Emha Ainun Nadjib yang berjudul Markesot Bertutur Lagi. Hasil penelitian ini menunjukkan bahwa pikiran damai Markesot dilakukan dengan enam cara. Pertama, berpikir konstruktif ketika melihat dan mengalami suatu fenomena. Kedua, berpikir kritis terhadap peristiwa yang terjadi. Ketiga, memaknai suatu fenomena dengan perspektif yang berbeda. Keempat, memiliki pola pikir bahwa hidup harus dengan pendirian yang positif. Kelima, melihat sebab akibat dari suatu permasalahan. Keenam, berpikir bahwa manusia memiliki kedaulatan terhadap dirinya sendiri. Pola pikir damai yang dimiliki markesot tersebut perlu diinternalisasi remaja sehingga remaja memiliki pola pikir damai dan terhindar dari perilaku agresi

Tetralogy of Fallot with rheumatic mitral stenosis: A case report

<p>Abstract</p> <p>Introduction</p> <p>Rheumatic and congenital heart diseases account for the majority of hospital admissions for cardiac patients in India. Tetralogy of Fallot is the most common congenital heart disease with survival to adulthood. Infective endocarditis accounts for 4% of admissions to a specialized unit for adult patients with a congenital heart lesion. This report is unique in that a severe stenotic lesion of the mitral valve, probably of rheumatic aetiology, was noted in an adult male with Tetralogy of Fallot.</p> <p>Case presentation</p> <p>An unusual association of rheumatic mitral stenosis in an adult Indian male patient aged 35 years with Tetralogy of Fallot and subacute bacterial endocarditis of the aortic valve is presented.</p> <p>Conclusion</p> <p>In this case report the diagnostic implications, hemodynamic and therapeutic consequences of mitral stenosis in Tetralogy of Fallot are discussed. In addition, the morbidity and mortality of infective endocarditis in adult patients with congenital heart disease are summarized. The risk of a coincident rheumatic process in patients with congenital heart disease is highlighted and the need for careful attention to this possibility during primary and follow-up evaluation of such patients emphasized.</p

Increasing the potential for malaria elimination by targeting zoophilic vectors

Countries in the Asia Pacific region aim to eliminate malaria by 2030. A cornerstone of malaria elimination is the effective management of Anopheles mosquito vectors. Current control tools such as insecticide treated nets or indoor residual sprays target mosquitoes in human dwellings. We find in a high transmission region in India, malaria vector populations show a high propensity to feed on livestock (cattle) and rest in outdoor structures such as cattle shelters. We also find evidence for a shift in vector species complex towards increased zoophilic behavior in recent years. Using a malaria transmission model we demonstrate that in such regions dominated by zoophilic vectors, existing vector control tactics will be insufficient to achieve elimination, even if maximized. However, by increasing mortality in the zoophilic cycle, the elimination threshold can be reached. Current national vector control policy in India restricts use of residual insecticide sprays to domestic dwellings. Our study suggests substantial benefits of extending the approach to treatment of cattle sheds, or deploying other tactics that target zoophilic behavior. Optimizing use of existing tools will be essential to achieving the ambitious 2030 elimination target

Partially distributed coordination with Reo and constraint automata

Algorithms and the Foundations of Software technolog

A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation

Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that takes place both in the cytoplasm and on the membrane. To model and analyze such multicompartmental processes, we developed a lattice-based Monte Carlo method, Spatiocyte that supports RD in volume and surface compartments at single molecule resolution. Stochasticity in RD and the excluded volume effect brought by intracellular molecular crowding, both of which can significantly affect RD and thus, cellular processes, are also supported. We verified the method by comparing simulation results of diffusion, irreversible and reversible reactions with the predicted analytical and best available numerical solutions. Moreover, to directly compare the localization patterns of molecules in fluorescence microscopy images with simulation, we devised a visualization method that mimics the microphotography process by showing the trajectory of simulated molecules averaged according to the camera exposure time. In the rod-shaped bacterium _Escherichia coli_, the division site is suppressed at the cell poles by periodic pole-to-pole oscillations of the Min proteins (MinC, MinD and MinE) arising from carefully orchestrated RD in both cytoplasm and membrane compartments. Using Spatiocyte we could model and reproduce the _in vivo_ MinDE localization dynamics by accounting for the established properties of MinE. Our results suggest that the MinE ring, which is essential in preventing polar septation, is largely composed of MinE that is transiently attached to the membrane independently after recruited by MinD. Overall, Spatiocyte allows simulation and visualization of complex spatial and reaction-diffusion mediated cellular processes in volumes and surfaces. As we showed, it can potentially provide mechanistic insights otherwise difficult to obtain experimentally

Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients

BACKGROUND: The study aimed at evaluating the prevalence of thyroid function abnormalities in patients with alopecia areata (AA) and its association with other autoimmune diseases and various autoimmune antibodies. METHOD: We retrospectively analyzed medical records of 123 patients with AA. The main site of involvement, pattern, and extent of alopecia as well as presence of the similar disease in first-degree family members and serologic status of patients were recorded. RESULTS: Participating in the study were 57 males and 66 females (6 to 59 years old). In the majority of patients (69.9%) the disease was manifested in the first two decades of life. Patients with family members having alopecia were recorded in 24.4%. Thyroid function abnormalities were found in 8.9% of patients. Positive autoimmune antibodies were associated with AA in 51.4% of patients with no significant association between the severity and duration of disease and presence of these antibodies. CONCLUSION: The incidence of positive auto-immune antibodies in Iranian patients is higher than previous reports. Concerning the female:male ratio, thyroid function tests and the prevalence of alopecia in first-degree relatives, our results are compatible with previous data obtained from different ethnic populations. Previous reports documented that a greater severity and longer duration of AA were seen in the early onset forms; however our result are relatively different which could be explained by differences in genetic factors

Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions

Polycaprolactone (PCL) nanoparticles were produced via supercritical fluid extraction of emulsions (SFEE) using supercritical carbon dioxide (scCO2). The efficiency of the scCO2 extraction was investigated and compared to that of solvent extraction at atmospheric pressure. The effects of process parameters including polymer concentration (0.6–10% w/w in acetone), surfactant concentration (0.07 and 0.14% w/w) and polymer-to-surfactant weight ratio (1:1–16:1 w/w) on the particle size and surface morphology were also investigated. Spherical PCL nanoparticles with mean particle sizes between 190 and 350 nm were obtained depending on the polymer concentration, which was the most important factor where increase in the particle size was directly related to total polymer content in the formulation. Nanoparticles produced were analysed using dynamic light scattering and scanning electron microscopy. The results indicated that SFEE can be applied for the preparation of PCL nanoparticles without agglomeration and in a comparatively short duration of only 1 h

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

Transglutaminase 2 (TG2) is a multifunctional mammalian protein with transamidase and signaling properties. Using selective TG2 inhibitors and tagged nucleophilic amine substrates, we show that the majority of extracellular TG2 is inactive under normal physiological conditions in cell culture and in vivo. However, abundant TG2 activity was detected around the wound in a standard cultured fibroblast scratch assay. To demonstrate wounding-induced activation of TG2 in vivo, the toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly(I:C)), was injected in mice to trigger small intestinal injury. Although no TG2 activity was detected in vehicle-treated mice, acute poly(I:C) injury resulted in rapid TG2 activation in the small intestinal mucosa. Our findings provide a new basis for understanding the role of TG2 in physiology and disease