Low-density Lipoprotein Cholesterol And Radiotherapy-induced Carotid Atherosclerosis In Subjects With Head And Neck Cancer

Background: Radiotherapy (RT) is a risk factor for accelerated carotid artery atherosclerotic disease in subjects with head and neck cancer. However, the risk factors of RT-induced carotid artery remodeling are not established. This study aimed to investigate the effects of RT on carotid and popliteal arteries in subjects with head and neck cancer and to evaluate the relationship between baseline clinical and laboratory features and the progression of RT-induced atherosclerosis.Findings: Eleven men (age = 57.9 ± 6.2years) with head and neck cancer who underwent cervical bilateral irradiation were prospectively examined by clinical and laboratory analysis and by carotid and popliteal ultrasound before and after treatment (mean interval between the end of RT and the post-RT assessment = 181 ± 47 days). No studied subject used hypocholesterolemic medications. Significant increases in carotid intima-media thickness (IMT) (0.95 ± 0.08 vs. 0.87 ± 0.05 mm; p 3.0.CO;2-X, 626923Pereira Lima, M.N., Biolo, A., Foppa, M., da Rosa, P.R., Rohde, L.E., Clausell, N., A prospective, comparative study on the early effects of local and remote radiation therapy on carotid intima-media thickness and vascular cellular adhesion molecule-1 in patients with head and neck and prostate tumors (2011) Radiother Oncol, 101, pp. 449-453. , 10.1016/j.radonc.2010.03.026, 20435360Kalábová, H., Melichar, B., Ungermann, L., Doležal, J., Krčmová, L., Kašparová, M., Plíšek, J., Solichová, D., Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy (2011) Med Oncol, 28, pp. 1281-1287. , 10.1007/s12032-010-9593-1, 20567943Muzaffar, K., Collins, S.L., Labropoulos, N., Baker, W.H., A prospective study of the effects of irradiation on the carotid artery (2000) Laryngoscope, 110, pp. 1811-1814. , 10.1097/00005537-200011000-00007, 11081590Faruolo, M., Fiorentino, A., Gallucci, G., Lapadula, L., Fusco, V., Intimal-medial thickness and carotid arteries lumen in irradiated patients for head and neck cancer: preliminary data of an observational study (2013) Clin Transl Oncol, 15, pp. 861-864. , 10.1007/s12094-013-1023-3, 23463595Ferreira-Sae, M.C., Cipolli, J.A., Cornélio, M.E., Matos-Souza, J.R., Fernandes, M.N., Schreiber, R., Costa, F.O., Nadruz, W., Sodium intake is associated with carotid artery structure alterations and plasma matrix metalloproteinase-9 upregulation in hypertensive adults (2011) J Nutr, 141, pp. 877-882. , 10.3945/jn.110.135921, 21430243Gemignani, T., Azevedo, R.C., Higa, C.M., Coelho, O.R., Matos-Souza, J.R., Nadruz, W., Increased popliteal circumferential wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques (2012) Atherosclerosis, 224, pp. 118-122. , 10.1016/j.atherosclerosis.2012.06.069, 2281862

Mechanistic insights and clinical relevance of the interaction between acute coronary syndromes and lipid metabolism

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Relationship Between Subjective Well-being And The Functionality Of Elderly Outpatients [relações Entre O Bem-estar Subjetivo E A Funcionalidade Em Idosos Em Seguimento Ambulatorial]

Objective: The aim of this study was to investigate the relationship between subjective well-being, functional independence and lower- limb performance (muscle strength, gait velocity and balance) among elderly people undergoing outpatient follow-up, stratified by sex and age groups. Methods: We evaluated 125 elderly people, aged 60 years and over, who received care at a geriatric outpatient clinic. The instruments used were: 1) Functional Independence Measure (FIM) to evaluate functional dependence; 2) Short Physical Performance Battery (SPPB) to measure physical performance; and 3) Subjective Well-Being (SWB) with questions about health and satisfaction with life. Results: A convenience sample was used, with predominance of females (who had greater functional impairment). The Spearman correlation coefficients for subjective well-being and the performance tests varied from -0.16 to 0.31 for men and -0.09 to 0.29 for women, therefore there were no differences between the sexes. However, the older participants had a higher level of satisfaction than the younger participants. Perceived health was also more satisfactory among the older participants, however comparative perceived health was better among the elderly participants with moderate to good physical performance. Conclusion: The results suggest that older individuals have greater satisfaction with life and better perceived health. Moreover, good physical performance was an important variable for better perceived health when compared to other people. © Revista Brasileira de Fisioterapia.1418189Diener, E., Suh, E., Measuring quality of life: Economic, social and subjective indicators (1997) Soc Ind Res, 40 (1-2), pp. 189-216Liberaslesso, A., Bienestar subjetivo en la vida adulta y en la vejez: Hacia una psicologia positiva en America Latina (2002) Rev Latinoam De Psicol, 34 (1-2), pp. 55-74Smiley, J.R., Ed Diener, , http://www.psych.uiuc.edu/~ediener/, [homepage na internet]. Champaign: University of Illinois at Urbana-Champaign [atualizada em 2006acesso em 13 Nov 2006]. Disponível emSousa, L., Galante, H., Figueiredo, D., Qualidade de vida e bem-estar dos idosos: Um estudo exploratório na população portuguesa (2003) Rev Saúde Pública, 37 (3), pp. 364-371Pereira, R.J., Cotta, R.M.M., Franceschini, S.C.C., Ribeiro, R.C.L., Sampaio, R.F., Priore, S.E., Contribuição dos domínios físico, social, psicológico e ambiental para a qualidade de vida global de idosos (2006) Rev Psiquiatr Rio Gd Sul, 28 (1), pp. 27-38Diogo, M.J.D., Satisfação global com a vida e determinados domínios entre idosos com amputação de membros inferiores (2003) Rev Panam Salud Publica, 13 (6), pp. 395-399Guedea, M.T.D., Albuquerque, F.J.B., Tróccoli, B.T., Noriega, J.A.V., Seabra, M.A.B., Guedea, R.L.D., Relação do bem-estar subjetivo, estratégias de enfrentamento e apoio social em idosos (2005) Pscicol Reflex Crit, 19 (2), pp. 301-308de Vitta, A., Neri, A.L., Padovani, C.R., Saúde percebida em homens e mulheres sedentários e ativos, adultos jovens e idosos (2006) Salusvita, 25 (1), pp. 22-34(2008) Política Nacional De Atenção À Saúde Dos Idosos, , http://portal.saude.gov.br/saude/area.cfm?id_area=153, Ministério da Saúde - Brasil [homepage na internet], atualizado 10 Dez 1999acesso em 15 Mar, Disponível em(2003) Classifi Cação Internacional De Funcionalidade, Incapacidade E Saúde-cif, , Organização Mundial da Saúde-OMS, 1. São Paulo: UdespRiberto, M., Myazaky, M.H., Jorge Filho, D., Sakamoto, H., Battistela, L.R., Reprodutibilidade da versão brasileira da medida de independência funcional (2001) Acta Fisiatrica, 8 (1), pp. 45-52Guralnik, J.M., Simonsick, E.M., Ferrucci, L., Glynm, R.J., Berkman, L.F., Blazer, D.G., A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission (1994) J Gerontol, 49 (2), pp. 85-94Neri, A.L., Qualidade de vida na velhice e atendimento domiciliário (2000) Atendimento Domiciliar: Um Enfoque Gerontológico, pp. 33-47. , In: Duarte YAO, Diogo MJD, editores, São Paulo: AteneuFerreira, F.F.P., Izzo, H., Jacob Filho, W., Impacto da capacidade física na saúde percebida entre idosos em velhice avançada (2007) Saúde Coletiva, 4 (17), pp. 154-157Ebly, E.M., Hogan, D.B., Fung, T.S., Correlates of self-rated health in persons aged 85 and over: Results from the Canadian study of health and aging (1996) Can J Public Health, 87 (1), pp. 28-31Baltes, P.B., Mayer, K.U., (1999) The Berlin Aging Study Aging From 70 to 100, , Cambridge: Cambridge University PressChang, M., Kim, H., Shigematsu, R., Nho, H., Nishijima, T., Tanaka, K., Functional fitness may be related to life satisfaction in older Japanese adults (2001) Int J Aging Hum Dev, 53 (1), pp. 35-49Wyller, T.B., Holmen, J., Laake, P., Laake, K., Correlates of subjective well-being in stroke patients (1998) Stroke, 29 (2), pp. 363-367Neri, A.L., (2007) Qualidade De Vida Na Velhice: Enfoque Multidisciplinar, , Campinas: Alínea EditoraWagnild, G., Resilience and successful aging. Comparison among low and high income older adults (2003) J Gerontol Nurs, 29 (12), pp. 42-49Rabelo, D.F., (2006) Incapacidade Funcional, Senso De Ajustamento Pessoal E Bem-estar Subjetivo Em Adultos E Idosos Afetados Por Acidente Vascular Cerebral [dissertação], , Campinas (SP): Universidade Estadual de CampinasFujita, F., Diener, E., Life satisfaction set point: Stability and change (2005) J Pers Soc Psychol, 88 (1), pp. 158-164Diener, E., Subjctive well-being. The science of happiness and a proposal for a national index (2000) Am Psychol, 55 (1), pp. 34-43Wink, P., Dillon, M., Religiousness, spirituality, and psychosocial functioning in late adulthood: Fi ndings from a longitudinal study (2003) Psycol Aging, 18 (4), pp. 916-924Alves, L.C., Rodrigues, R.N., Determinates da autopercepção de saúde entre idosos do município de São Paulo, Brasil (2005) Rev Panam Salud Publica, 17 (5-6), pp. 333-340Bravell, M.E., Berg, S., Malmberg, B., Health, functional capacity, formal care, and survival in the oldest old: A longitudinal study (2008) Arch Gerontol Geriatr, 46 (1), pp. 1-14Diener, E., Fujita, F., Social comparisons and subjective well-being (1997) Helath, Coping, and Well-being: Perspectives From Social Comparison Theory, pp. 305-324. , In: Buunk BP, Gibbsons F, editors, New Jersey: Laurence Erlbawm AssociatesBuunk, B.P., Gibbons, F.X., Reis-Bergan, M., Social comparison in health and illness: A historical overview (1997) Health, Coping, and Well-being: Perspectives From Social Comparison Theory, pp. 1-23. , In: Buunk BP, Gibbsons F, editors., New Jersey: Laurence Erlbawm AssociatesWills, T.A., Modes and families of coping: An analysis of social comparison in the structure of other cognitive and behavioral mechanisms (1997) Helath, Coping, and Well-being: Perspectives From Social Comparison Theory, pp. 167-194. , In: Buunk BP, Gibbsons F, editors., New Jersey: Laurence Erlbawm AssociatesAldwin, C.M., Gilmer, D.F., (2004) Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, , Los Angeles: Sag

Apoliprotein E Genotype Is Associated With Apoliprotein B Plasma Levels But Not With Coronary Calcium Score In Very Elderly Individuals In Primary Care Setting

Background: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. Aim: We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. Methods: We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across ε2, ε3 and ε4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. Results: When non- ε4 carriers were compared with ε4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. Conclusion: The study suggests a possible atherogenic role of the ε4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting. © 2014 Elsevier B.V.5392275278Alvim, R.O., APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population (2010) Lipids Health Dis., 9, p. 128. , (PubMed PMID: 21059196. Pubmed Central PMCID: 2992057)Aulchenko, Y.S., Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts (2009) Nat. Genet., 41 (1), pp. 47-55. , (Jan, PubMed PMID: 19060911. Pubmed Central PMCID: 2687074)Bagger, Y.Z., Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se? (2007) Osteoporos. 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