1,902 research outputs found
A calorimeter coupled with a magnetic spectrometer for the detection of primary cosmic antiprotons
A tracking calorimeter made of 3200 brass streamer tubes together with 3200 pick-up strips has been built to complement a magnetic spectrometer in order to detect cosmic antiprotons in space. The characteristics of such a calorimeter, the results of a preliminary test of a prototype as well as the properties of the whole apparatus are presented. The apparatus, designed to operate on a balloon at an altitude of about 40 km, can be considered as a second generation detector, capable in principle to solve the problem of the presence of low energy (≤1 Ge V/c) antiprotons in the cosmic rays which is still open because of the disagreement between the existent experimental data
Redistribution of DAT/α-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease
Alpha-synuclein, the major component of Lewy bodies, is thought to play a central role in the onset of synaptic dysfunctions in Parkinson's disease (PD). In particular, α-synuclein may affect dopaminergic neuron function as it interacts with a key protein modulating dopamine (DA) content at the synapse: the DA transporter (DAT). Indeed, recent evidence from our "in vitro" studies showed that α-synuclein aggregation decreases the expression and membrane trafficking of the DAT as the DAT is retained into α-synuclein-immunopositive inclusions. This notwithstanding, "in vivo" studies on PD animal models investigating whether DAT distribution is altered by the pathological overexpression and aggregation of α-synuclein are missing. By using the proximity ligation assay, a technique which allows the "in situ" visualization of protein-protein interactions, we studied the occurrence of alterations in the distribution of DAT/α-synuclein complexes in the SYN120 transgenic mouse model, showing insoluble α-synuclein aggregates into dopaminergic neurons of the nigrostriatal system, reduced striatal DA levels and an altered distribution of synaptic proteins in the striatum. We found that DAT/α-synuclein complexes were markedly redistributed in the striatum and substantia nigra of SYN120 mice. These alterations were accompanied by a significant increase of DAT striatal levels in transgenic animals when compared to wild type littermates. Our data indicate that, in the early pathogenesis of PD, α-synuclein acts as a fine modulator of the dopaminergic synapse by regulating the subcellular distribution of key proteins such as the DAT
Spatial Resolution of Double-Sided Silicon Microstrip Detectors for the PAMELA Apparatus
The PAMELA apparatus has been assembled and it is ready to be launched in a
satellite mission to study mainly the antiparticle component of cosmic rays. In
this paper the performances obtained for the silicon microstrip detectors used
in the magnetic spectrometer are presented. This subdetector reconstructs the
curvature of a charged particle in the magnetic field produced by a permanent
magnet and consequently determines momentum and charge sign, thanks to a very
good accuracy in the position measurements (better than 3 um in the bending
coordinate). A complete simulation of the silicon microstrip detectors has been
developed in order to investigate in great detail the sensor's characteristics.
Simulated events have been then compared with data gathered from minimum
ionizing particle (MIP) beams during the last years in order to tune free
parameters of the simulation. Finally some either widely used or original
position finding algorithms, designed for such kind of detectors, have been
applied to events with different incidence angles. As a result of the analysis,
a method of impact point reconstruction can be chosen, depending on both the
particle's incidence angle and the cluster multiplicity, so as to maximize the
capability of the spectrometer in antiparticle tagging.Comment: 28 pages, 18 figures, submitted to Nuclear Instruments and Methods in
Physics Research
The Cosmic-Ray Proton and Helium Spectra measured with the CAPRICE98 balloon experiment
A new measurement of the primary cosmic-ray proton and helium fluxes from 3
to 350 GeV was carried out by the balloon-borne CAPRICE experiment in 1998.
This experimental setup combines different detector techniques and has
excellent particle discrimination capabilities allowing clear particle
identification. Our experiment has the capability to determine accurately
detector selection efficiencies and systematic errors associated with them.
Furthermore, it can check for the first time the energy determined by the
magnet spectrometer by using the Cherenkov angle measured by the RICH detector
well above 20 GeV/n. The analysis of the primary proton and helium components
is described here and the results are compared with other recent measurements
using other magnet spectrometers. The observed energy spectra at the top of the
atmosphere can be represented by (1.27+-0.09)x10^4 E^(-2.75+-0.02) particles
(m^2 GeV sr s)^-1, where E is the kinetic energy, for protons between 20 and
350 GeV and (4.8+-0.8)x10^2 E^(-2.67+-0.06) particles (m^2 GeV nucleon^-1 sr
s)^-1, where E is the kinetic energy per nucleon, for helium nuclei between 15
and 150 GeV nucleon^-1.Comment: To be published on Astroparticle Physics (44 pages, 13 figures, 5
tables
Status of the PAMELA silicon tracker
PAMELA is a composite particle detector which will be launched during the first half of 2006 on board the Russian satellite Resurs DK-1 from Baikonur cosmodrome in Kazakhstan. This experiment is mainly conceived for the study of cosmic-ray antiparticles and for the search for light antinuclei, but other issues related to the cosmic-ray physics will be investigated. In this work the structure of the whole apparatus is shortly discussed with particular attention to the magnetic spectrometer, which has been designed and built in Firenze
Dark Matter Search Perspectives with GAMMA-400
GAMMA-400 is a future high-energy gamma-ray telescope, designed to measure
the fluxes of gamma-rays and cosmic-ray electrons + positrons, which can be
produced by annihilation or decay of dark matter particles, and to survey the
celestial sphere in order to study point and extended sources of gamma-rays,
measure energy spectra of Galactic and extragalactic diffuse gamma-ray
emission, gamma-ray bursts, and gamma-ray emission from the Sun. GAMMA-400
covers the energy range from 100 MeV to ~3000 GeV. Its angular resolution is
~0.01 deg(Eg > 100 GeV), and the energy resolution ~1% (Eg > 10 GeV). GAMMA-400
is planned to be launched on the Russian space platform Navigator in 2019. The
GAMMA-400 perspectives in the search for dark matter in various scenarios are
presented in this paperComment: 4 pages, 4 figures, submitted to the Proceedings of the International
Cosmic-Ray Conference 2013, Brazil, Rio de Janeir
The silicon microstrip detectors of the PAMELA experiment: simulation and test results
Abstract The PAMELA detector will fly at the beginning of 2004 on board the Russian satellite Resurs–DK for a 3-year mission designed to study mainly antiparticles in cosmic rays. The core of the apparatus is a magnetic spectrometer in which silicon microstrip detectors are employed. A dedicated simulation study, tuned on beam test data, is presented: it allows to determine the best position finding algorithm for different incidence angles
- …