607 research outputs found
Two little girls in blue: waltz song
https://digitalcommons.ithaca.edu/sheetmusic/1073/thumbnail.jp
Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility.
Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2). We recently reported that MMP-2 levels were increased in the border zone after a MI and that treatment with doxycycline for two weeks after MI was associated with normalization of MMP-2 levels and improvement in ex-vivo contractile protein developed force in the myocardial border zone. The purpose of the current study was to determine if there is a sustained effect of short term treatment with doxycycline (Dox) on border zone function in a large animal model of antero-apical myocardial infarction (MI). Antero-apical MI was created in 14 sheep. Seven sheep received doxycycline 0.8 mg/kg/hr IV for two weeks. Cardiac MRI was performed two weeks before, and then two and six weeks after MI. Two sheep died prior to MRI at six weeks from surgical/anesthesia-related causes. The remaining 12 sheep completed the protocol. Doxycycline induced a sustained reduction in intracellular MMP-2 by Western blot (3649±643 MI+Dox vs 9236±114 MI relative intensity; p = 0.0009), an improvement in ex-vivo contractility (65.3±2.0 MI+Dox vs 39.7±0.8 MI mN/mm2; p<0.0001) and an increase in ventricular wall thickness at end-systole 1.0 cm from the infarct edge (12.4±0.6 MI+Dox vs 10.0±0.5 MI mm; p = 0.0095). Administration of doxycycline for a limited two week period is associated with a sustained improvement in ex-vivo contractility and an increase in wall thickness at end-systole in the border zone six weeks after MI. These findings were associated with a reduction in intracellular MMP-2 activity
Dyadic Speech-based Affect Recognition using DAMI-P2C Parent-child Multimodal Interaction Dataset
Automatic speech-based affect recognition of individuals in dyadic
conversation is a challenging task, in part because of its heavy reliance on
manual pre-processing. Traditional approaches frequently require hand-crafted
speech features and segmentation of speaker turns. In this work, we design
end-to-end deep learning methods to recognize each person's affective
expression in an audio stream with two speakers, automatically discovering
features and time regions relevant to the target speaker's affect. We integrate
a local attention mechanism into the end-to-end architecture and compare the
performance of three attention implementations -- one mean pooling and two
weighted pooling methods. Our results show that the proposed weighted-pooling
attention solutions are able to learn to focus on the regions containing target
speaker's affective information and successfully extract the individual's
valence and arousal intensity. Here we introduce and use a "dyadic affect in
multimodal interaction - parent to child" (DAMI-P2C) dataset collected in a
study of 34 families, where a parent and a child (3-7 years old) engage in
reading storybooks together. In contrast to existing public datasets for affect
recognition, each instance for both speakers in the DAMI-P2C dataset is
annotated for the perceived affect by three labelers. To encourage more
research on the challenging task of multi-speaker affect sensing, we make the
annotated DAMI-P2C dataset publicly available, including acoustic features of
the dyads' raw audios, affect annotations, and a diverse set of developmental,
social, and demographic profiles of each dyad.Comment: Accepted by the 2020 International Conference on Multimodal
Interaction (ICMI'20
Dimension reduction for systems with slow relaxation
We develop reduced, stochastic models for high dimensional, dissipative
dynamical systems that relax very slowly to equilibrium and can encode long
term memory. We present a variety of empirical and first principles approaches
for model reduction, and build a mathematical framework for analyzing the
reduced models. We introduce the notions of universal and asymptotic filters to
characterize `optimal' model reductions for sloppy linear models. We illustrate
our methods by applying them to the practically important problem of modeling
evaporation in oil spills.Comment: 48 Pages, 13 figures. Paper dedicated to the memory of Leo Kadanof
The catch 22 of condoms in US correctional facilities
<p>Abstract</p> <p>Background</p> <p>Despite the high prevalence of sexually transmitted infections (STIs) and HIV infection in US correctional settings, most jails and prisons in the United States prevent inmates from using condoms to prevent STIs/HIV.</p> <p>Discussion</p> <p>This article makes the following arguments to justify a scalable and feasible next step in the prevention of HIV/STIs among inmates: condoms are a basic and essential part of HIV/STI prevention, HIV/STI transmission occurs in the context of corrections, and several model programs show the feasibility of condom distribution in prisons. A lower end estimate for HIV incidence among incarcerated applied to 2,000,000 new inmates annually results in thousands of new HIV infections acquired each year in corrections that could be prevented with condoms in corrections facilities. Programs from parts of the United States, Canada, and much of Europe show how programs distributing condoms in correctional facilities can be safe and effective.</p> <p>Summary</p> <p>Public health and corrections officials must work together to ensure that condoms and broader sexual disease prevention programs are integrated into US jail and prison health systems.</p
The medical student
The Medical Student was published from 1888-1921 by the students of Boston University School of Medicine
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Pulsed Photonuclear Assessment (PPA) Technique: CY-05 Project Summary Report
Idaho National Laboratory, along with Idaho State University’s Idaho Accelerator Center and Los Alamos National Laboratory, is developing an electron accelerator-based, photonuclear inspection technology, called the Pulsed Photonuclear Assessment (PPA) system, for the detection of nuclear material concealed within air-, rail-, and, primarily, maritime-cargo transportation containers. This report summarizes the advances and progress of the system’s development in 2005. The contents of this report include an overview of the prototype inspection system, selected Receiver-Operator-Characteristic curves for system detection performance characterization, a description of the approach used to integrate the three major detection components of the PPA inspection system, highlights of the gray-scale density mapping technique being used for significant shield material detection, and higher electron beam energy detection results to support an evaluation for an optimal interrogating beam energy. This project is supported by the Department of Homeland Security Office of Research and Development and, more recently, the Domestic Nuclear Detection Office
Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis
Objective To compare the effectiveness and safety of three types of stents (sirolimus eluting, paclitaxel eluting, and bare metal) in people with and without diabetes mellitus
ホンヤク シン ジツザイロン テツガク ニ オケル キョウドウ ケンキュウ ジョブン
その他、フォーラム報告等(翻訳原稿)原著:Edwin Bissell Holt, Walter Taylor Marvin, William Pepperell Montague, Ralph Barton Perry, Walter Boughton Pitkin, Edward Gleason Spaulding, (1912),The New Realism : Cöperative Studies in Philosophy, New York The Macmillan Company.翻訳:豊泉, 俊大 / 磯島, 浩
Routine Opt-Out HIV Testing Strategies in a Female Jail Setting: A Prospective Controlled Trial
Background: Ten million Americans enter jails annually. The objective was to evaluate new CDC guidelines for routine optout HIV testing and examine the optimal time to implement routine opt-out HIV testing among newly incarcerated jail detainees. Methods: This prospective, controlled trial of routine opt-out HIV testing was conducted among 323 newly incarcerated female inmates in Connecticut’s only women’s jail. 323 sequential entrants to the women’s jail over a five week period in August and September 2007 were assigned to be offered routine opt-out HIV testing at one of three points after incarceration: immediate (same day, n = 108), early (next day, n = 108), or delayed (7 days, n = 107). The primary outcome was the proportion of women in each group consenting to testing. Results: Routine opt-out HIV testing was significantly highest (73%) among the early testing group compared to 55 % for immediate and 50 % for 7 days post-entry groups. Other factors significantly (p = 0.01) associated with being HIV tested were younger age and low likelihood of early release from jail based on bond value or type of charge for which women were arrested. Conclusions: In this correctional facility, routine opt-out HIV testing in a jail setting was feasible, with highest rates of testing if performed the day after incarceration. Lower testing rates were seen with immediate testing, where there is a high prevalence of inability or unwillingness to test, and with delayed testing, where attrition from jail increases with each passing day
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