5,063 research outputs found
Stable ferromagnetism in p-type carbon-doped ZnO nanoneedles
Author name used in this publication: C. S. Wei2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Self Injection length in La0.7 Ca0.3 Mno3-YBa 2Cu3O7-d ferromagnet- superconductor multi layer thin films
We have carried out extensive studies on the self-injection problem in
barrierless heterojunctions between La0.7Ca0.3MnO3 (LCMO) and YBa2Cu3O7-d
(YBCO). The heterojunctions were grown in situ by sequentially growing LCMO and
YBCO films on LaAlO3 (LAO) substrate using a pulsed laser deposition
(PLD) system. YBCO micro-bridges with 64 microns width were patterned both on
the LAO (control) and LCMO side of the substrate. Critical current, Ic, was
measured at 77K on both the control side as well as the LCMO side for different
YBCO film thickness. It was observed that while the control side showed a Jc of
~2 x 10E6 A/ cm2 the LCMO side showed about half the value for the same
thickness (1800 A). The difference in Jc indicates that a certain thickness of
YBCO has become 'effectively' normal due to self-injection. From the
measurement of Jc at two different thickness' (1800 A and 1500 A) of YBCO both
on the LAO as well as the LCMO side, the value of self-injection length (at
77K) was estimated to be ~900 A self-injection length has been quantified. A
control experiment carried out with LaNiO3 deposited by PLD on YBCO did not
show any evidence of self-injection.Comment: 6 pages, one figure in .ps forma
Beating the channel capacity limit for linear photonic superdense coding
Dense coding is arguably the protocol that launched the field of quantum
communication. Today, however, more than a decade after its initial
experimental realization, the channel capacity remains fundamentally limited as
conceived for photons using linear elements. Bob can only send to Alice three
of four potential messages owing to the impossibility of carrying out the
deterministic discrimination of all four Bell states with linear optics,
reducing the attainable channel capacity from 2 to log_2 3 \approx 1.585 bits.
However, entanglement in an extra degree of freedom enables the complete and
deterministic discrimination of all Bell states. Using pairs of photons
simultaneously entangled in spin and orbital angular momentum, we demonstrate
the quantum advantage of the ancillary entanglement. In particular, we describe
a dense-coding experiment with the largest reported channel capacity and, to
our knowledge, the first to break the conventional linear-optics threshold. Our
encoding is suited for quantum communication without alignment and satellite
communication.Comment: Letter: 6 pages, 4 figures. Supplementary Information: 4 pages, 1
figur
Demon-like Algorithmic Quantum Cooling and its Realization with Quantum Optics
The simulation of low-temperature properties of many-body systems remains one
of the major challenges in theoretical and experimental quantum information
science. We present, and demonstrate experimentally, a universal cooling method
which is applicable to any physical system that can be simulated by a quantum
computer. This method allows us to distill and eliminate hot components of
quantum states, i.e., a quantum Maxwell's demon. The experimental
implementation is realized with a quantum-optical network, and the results are
in full agreement with theoretical predictions (with fidelity higher than
0.978). These results open a new path for simulating low-temperature properties
of physical and chemical systems that are intractable with classical methods.Comment: 7 pages, 5 figures, plus supplementarity material
Dramatic escalation in metabolic syndrome and cardiovascular risk in a Chinese population experiencing rapid economic development
Background
Metabolic syndrome (MetSyn) increases the incidence of cardiovascular disease. Information on changes in prevalence of MetSyn in developing countries is limited. This study aims to compare MetSyn prevalence and its associated vascular risk over the period between 2002 and 2010 in a population which has had the world’s fastest economic development over the past three decades.
Methods
Two health surveys were conducted by using the multistage cluster random sampling method in a Chinese population of 85 million in southern China. The participants received a full medical check-up, including measurement of blood pressure (BP), obesity indices, fasting lipids and glucose levels. Data describing socio-economic status and lifestyle factors were also collected through interview. Metabolic syndrome was defined in accordance with the International Diabetes Federation criteria.
Results
A total of 3,561 participants from Survey 2010 were included in the data analysis. Women had a significantly higher prevalence of MetSyn than men. Comparison between the two surveys shows that age-standardized prevalence of MetSyn increased fourfold (from 5.4% in 2002 to 21.3% in 2010) in those ≧ 20 years. Among the MetSyn components, prevalence of hyperglycaemia has increased most (from 9.1% to 53.1%). The age-standardized prevalence of central obesity, hypertension, hypertriglyceridaemia and low HDL-cholesterol increased from 13.5% to 25.4%, from 23.6% to 40.8%, from 12.1% to 17.4% and from 32.1% to 71.1%, respectively. Differences between rural and urban residents in the prevalence in MetSyn and its components narrowed in 2010.
Conclusions
Cardiovascular risk escalated dramatically in this population between 2002 and 2010. The escalation may relate to the rapid economic development, which led to accelerating changes in nutrition, lifestyle, and socio-economic status. Our findings suggest that health transition in rapidly developing second- and third-world countries may be much faster than what has been observed in Western countries.published_or_final_versio
Partitioning of on-demand electron pairs
We demonstrate the high fidelity splitting of electron pairs emitted on
demand from a dynamic quantum dot by an electronic beam splitter. The fidelity
of pair splitting is inferred from the coincidence of arrival in two detector
paths probed by a measurement of the partitioning noise. The emission
characteristic of the on-demand electron source is tunable from electrons being
partitioned equally and independently to electron pairs being split with a
fidelity of 90%. For low beam splitter transmittance we further find evidence
of pair bunching violating statistical expectations for independent fermions
Ultra-Sensitive Hot-Electron Nanobolometers for Terahertz Astrophysics
The background-limited spectral imaging of the early Universe requires
spaceborne terahertz (THz) detectors with the sensitivity 2-3 orders of
magnitude better than that of the state-of-the-art bolometers. To realize this
sensitivity without sacrificing operating speed, novel detector designs should
combine an ultrasmall heat capacity of a sensor with its unique thermal
isolation. Quantum effects in thermal transport at nanoscale put strong
limitations on the further improvement of traditional membrane-supported
bolometers. Here we demonstrate an innovative approach by developing
superconducting hot-electron nanobolometers in which the electrons are cooled
only due to a weak electron-phonon interaction. At T<0.1K, the electron-phonon
thermal conductance in these nanodevices becomes less than one percent of the
quantum of thermal conductance. The hot-electron nanobolometers, sufficiently
sensitive for registering single THz photons, are very promising for
submillimeter astronomy and other applications based on quantum calorimetry and
photon counting.Comment: 19 pages, 3 color figure
Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens.
BackgroundTo determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.MethodsTen CLL specimens and five normal peripheral blood CD19+ B cells were analyzed by HTS RNA-seq. The library preparation was performed with Illumina TrueSeq RNA kit and analyzed by Illumina HiSeq 2000 sequencing system.ResultsAn average of 48.5 million reads for B cells, and 50.6 million reads for CLL specimens were obtained with 10396 and 10448 assembled transcripts for normal B cells and primary CLL specimens respectively. With the Cuffdiff analysis, 2091 differentially expressed genes (DEG) between B cells and CLL specimens based on FPKM (fragments per kilobase of transcript per million reads and false discovery rate, FDR q < 0.05, fold change >2) were identified. Expression of selected DEGs (n = 32) with up regulated and down regulated expression in CLL from RNA-seq data were also analyzed by qRT-PCR in a test cohort of CLL specimens. Even though there was a variation in fold expression of DEG genes between RNA-seq and qRT-PCR; more than 90 % of analyzed genes were validated by qRT-PCR analysis. Analysis of RNA-seq data for splicing alterations in CLL and B cells was performed by Multivariate Analysis of Transcript Splicing (MATS analysis). Skipped exon was the most frequent splicing alteration in CLL specimens with 128 significant events (P-value <0.05, minimum inclusion level difference >0.1).ConclusionThe RNA-seq analysis of CLL specimens identifies novel DEG and alternatively spliced genes that are potential prognostic markers and therapeutic targets. High level of validation by qRT-PCR for a number of DEG genes supports the accuracy of this analysis. Global comparison of transcriptomes of B cells, IGVH non-mutated CLL (U-CLL) and mutated CLL specimens (M-CLL) with multidimensional scaling analysis was able to segregate CLL and B cell transcriptomes but the M-CLL and U-CLL transcriptomes were indistinguishable. The analysis of HTS RNA-seq data to identify alternative splicing events and other genetic abnormalities specific to CLL is an added advantage of RNA-seq that is not feasible with other genome wide analysis
Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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