Chitosan-based films for wound healing applications: A meta- analysis to access the impact on wound closure rate

Wound healing novel materials have been emerging as a hot topic, as wounds are reaching epidemic proportions, with both economic and psychosocial consequences. Chitosan-based films increase the rate of re-epithelialization and wound closure rate which, due to their antimicrobial properties, should contribute to wound closure. With the constant raise of scientific publications regarding this subject, we aimed to establish a direct relation of chitosan films on wound closure rate based on recent data. The available literature was gathered from Scopus database, followed by a bibliometric analysis. Results were sorted based on wound closure metrics and statistical information. The data extracted from the selected articles were analyzed and compared regarding the wound closure rate measured in animal models. The results showed good homogeneity of positive results among the studies selected. On the other hand, due to unstandardized parameters in chitosan films formulations among the articles studied here, no correlation with chitosan concentration in wound dressing films with the woundclosure effect could be observed. However, further investigations of such correlation with clinical tests are still needed. In this context, this work demonstrated consistency in the positive impact of chitosan films on wound healing, demonstrating thatchitosan films have the potential for biomedical use and their research is justified. The results of this work might help to understand the relationship between the actual contribution of chitosan and in vivo wound healing evaluation, and provide areference to new approaches for the treatment chronic wounds

Nanoparticles improving polyaniline electrical conductivity: A meta-analysis study

Polyaniline is a conductive polymer that attracts the attention of many researchers around the world. The history of this polymer begins in 1862 when Letheby first reported this material. Since then, a myriad of studies has been conducted onthis material, and new works continue to investigate the potential of this material. Polyaniline has been improved with the help of Nanotechnology. The use of nanofillers has been seen as a quick and economical way to modify materials, drivinginnovations based on new physical and chemical properties from the conductive polymer materials and nanoparticles joining. Several works address the use of different nanoparticles, which leads to the practical impossibility of sifting through all this information. Thus, this work proposes to systematically collect data in the literature and investigate which nanoparticles can increase the electrical conductivity of Polyaniline (PAni). The results obtained demonstrate that among the possiblenanofillers, graphene and carbon nanotubes have great prominence. Furthermore, the results of the meta-analysis prove that PAni's conductivity increases when this polymer is modified with the aforementioned nanofillers

Salivary Alterations in Rats with Experimental Chronic Kidney Disease

Objective This study aimed to analyze changes in saliva composition and salivary secretion process of rats with chronic kidney disease induced by 5/6 nephrectomy to set the foundation for salivary studies related to CKD. Methods CKD was induced in Wistar rats via 5/6 nephrectomy. Blood and saliva samples were collected from Control, Sham and CKD groups at 8 and 12 weeks after the surgery. Salivation was stimulated via intraperitoneal injections of pilocarpine (1.0 mg/Kg body weight) or isoproterenol (5.0 mg/Kg body weight). Saliva was collected and immediately stored at -80 degrees C until analysis. The salivary flow rate, total protein, amylase and peroxidase activities, and urea concentrations were measured. The blood urea nitrogen (BUN) and serum creatinine concentrations were also evaluated. Results Increases in BUN and serum creatinine concentrations were observed in the CKD groups. Amylase activity was significantly reduced in response to both stimuli in the CKD groups at 8 weeks and increased in the CKD groups at 12 weeks in response to isoproterenol stimulus. The peroxidase activities of the CKD groups were significantly reduced in response to isoproterenol stimulation and were increased at 12 weeks in response to pilocarpine stimulation. Salivary urea was significantly increased in the CKD groups at 8 weeks in response to the isoproterenol stimuli and at 12 weeks in response to both salivary agonists. Conclusions The pattern of alterations observed in this experimental model is similar to those observed in patients and clearly demonstrates the viability of 5/6 nephrectomy as an experimental model in future studies to understand the alterations in salivary compositions and in salivary glands that are elicited by CKD.FAPESP (the Research Council for the State of Sao Paulo)Univ Sao Paulo, Dept Biomat & Biol Oral, Fac Odontol, Sao Paulo, BrazilEscola Paulista Med UNIFESP, Dept Fisiol, Sao Paulo, BrazilEscola Paulista Med UNIFESP, Dept Fisiol, Sao Paulo, BrazilFAPESP: 2013-18609-1Web of Scienc

INFLUÊNCIA DOS FATORES SOCIOECONÔMICOS NO DESENVOLVIMENTO DO PESO EM ESCOLARES DE FEIRA DE SANTANA-BA

Nas últimas décadas, importantes mudanças econômicas, sociais e tecnológicas propiciaram alterações no perfil epidemiológico das doenças nas sociedades modernas. Nesse cenário, variações nos indicadores nutricionais favoreceram um aumento significativo da obesidade, observado tanto em adultos quanto em crianças. Dados recentes do NCD Risk Factor Collaboration mostram que essa condição afeta cerca de 671 milhões de adultos no mundo, o que representa aproximadamente 10% da população mundial (NCD-RISC, 2017)

Development and validation of a stability indicating HPLC method to determine diltiazem hydrochloride in tablets and compounded capsules

A stability indicating HPLC method to determine diltiazem hydrochloride (DTZ) in tablets and compounded capsules was developed and validated according to Brazilian and the International Conference on Harmonization (ICH) guidelines. The separation was carried out on a Purospher Star® C18 (150 x 4.6 mm i.d., 5 µm particle size, Merck Millipore) analytical column. The mobile phase consisted of a 0.05% (v/v) trifluoroacetic acid aqueous solution and a 0.05% trifluoroacetic acid methanolic solution (44:56, v/v). The flow rate was 1.0 mL.min-1 with a run time of 14 minutes. The detection of DTZ and degradation products (DP) was performed at 240 nm, using a diode array detector. The method proved to be linear, precise, accurate, selective, and robust, and was adequate for stability studies and routine quality control analyses of DTZ in tablets and compounded capsules

Proporcionando atualizações em nutrição para a comunidade - 53955031

Trabalho apresentado no 31º SEURS - Seminário de Extensão Universitária da Região Sul, realizado em Florianópolis, SC, no período de 04 a 07 de agosto de 2013 - Universidade Federal de Santa Catarina.A nutrição desportiva visa orientar para que a alimentação e a hidratação realizadas antes, durante e após as modalidades desportivas sejam de boas escolhas, favorecendo o bem-estar do indivíduo. Os escolares que apresentam melhor rendimento desportivo são aqueles que têm garantidos, em seus organismos, adequados suprimentos de energia, nutrientes e, de líquidos corporais, contribuindo para com o desenvolvimento de jogos escolares e as modalidades em aulas de educação física, que requerem esforço físico. É usual que muitas crianças e adolescentes não realizem o desjejum antes de irem à escola e, com isso, seu rendimento na atividade desportiva ficará aquém de seu potencial, caso não ingiram alimentos e tomem líquidos antes das aulas de educação física. O mesmo se aplica em situações de preparo de alunos para campeonatos estudantis, nos turnos inversos ao horário de aulas. A Nutrição se dedica a orientar para que as referidas escolhas alimentícias por escolares sejam saudáveis, apropriadas ao processo digestório do momento, promovam o aporte energético e de hidratação requeridos ao desporto, antes, durante e após a atividade física

Sustainable citizen decision-making:Impact of the cost-of-living crisis on the energy and circular economy transitions in urban Scotland

The present report is the outcome of a research project commissioned by Zero Waste Scotland and carried out by the Just Transition Hub (JTH), University of Dundee, with the objective of understanding the ways in which the cost-of-living crisis has affected the attitudes and behaviours of individuals and communities towards a transition to a low-carbon economy in Scotland. We define the transition as encompassing both energy transition and the transition to a circular economy, so in this report the word “transition(s)” means both the referred transitions. We define the scope of “justice” to cover three dimensions – distributive, recognition and procedural. Briefly, distributive justice concerns the ideal of a fair share of the benefits and costs of the transition among different communities and stakeholders. Recognition justice respects the proper acknowledgement of marginalised individuals and communities who may be living in deprived urban areas. Procedural justice respects inclusion and effective participation of all, including marginalised actors, in public debate and decision-making. The study involved a literature review in narrative form (chapter 2) and a smallscale exploratory study (chapters 3 and 4), using a multi-strategy approach that included seven individual semi-structured expert interviews, four semi-structured citizen/consumer focus groups and one semi-structured expert focus group. Both the literature review and the empirical research adopted a thematic analysis approach, with clear research objectives identified in a standardised analysis framework. The present research is part of a broader series of investigations commissioned by Zero Waste Scotland to understand circular economy perspectives and sustainable decision-making in times of crises to help inform Zero Waste Scotland’s communication, engagement and further research for a just transition. The present study is complemented by parallel research being conducted by the University of Highlands and Islands with a focus on rural communities

Catarrhal mastitis by Staphylococcus simulans in a nulliparous goat

O presente trabalho é o relato do caso de uma cabra nulípara da raça Parda Alpina, de um ano de idade, pertencente ao Setor de Caprinocultura da Universidade Federal da Paraíba – Bananeiras - Brasil. Ambas as glândulas foram naturalmente infectadas por Staphylococcus simulans α-hemolítico. As glândulas mamárias apresentaram mastite aguda catarral com envolvimento sistêmico, respondendo positivamente ao tratamento sistêmico com gentamicina associada a amoxicilina. O presente relato sugere a importância do potencial patogênico de Staphylococcus não-aureus (SNA) como causador de mastite clínica também em animais nulíparos. O isolado mostrou resistência a tetraciclina e continha genes de produção de toxinas estafilocócicas (sec, seg e TSST-1). Além disso, tem sido relatado que Staphylococcus simulans é um patógeno emergente em seres humanos causando infecções cutâneas e osteoarticulares, principalmente naqueles que têm contato íntimo com animais de fazenda. Até onde sabemos, este é o primeiro relato de uma mastite clínica em uma cabra nulípara causada por Staphylococcus simulans.The present paper is a case report of a one-year old nulliparous Alpine Goat belonging to a dairy goat farm in semi-arid region of Brazil. Both glands were naturally infected by α-hemolytic Staphylococcus simulans and evolved similar clinical signs. The mammary glands presented an acute catarrhal mastitis with systemic clinical signs that responded positively to treatment with gentamicin associated with amoxicillin. The present report suggests the importance of the pathogenic potential of non-aureus Staphylococci strains (NAS) as a cause of clinical mastitis also in nulliparous animals. The isolate showed resistance to tetracycline and contained staphylococcal toxin production genes (sec, sec and TSST-1). Moreover, it has been reported that Staphylococcus simulans is an emerging pathogen in humans causing cutaneous and osteoarticular infections, mainly in those in close contact with farm animals. To the best of our knowledge, this is the first report of a clinical mastitis in a nulliparous goat caused by Staphylococcus simulans