Experimental Tool of woven Reinforcement Forming

International audienceThis paper concerns the development of an experimental device which is able to form very complex double curved geometry. Objectives are to analyze the evolution of the woven preform during the forming process. This device contains one mechanical module containing the classical tools in forming process, (punch, blank holder, and open-die), and one optical module to measure the 3D-deformed shape and the distribution of local deformations, like shear angles of the woven reinforcement during all the process. Experimental results are obtained with an interlock carbon woven fabric, used in aeronautical applications. Wrinkling and buckling will be analyzed at the global scale of the piece. The evolution of the shear angle will be presented at local scale (on face, or edges of the geometry)

ANALISIS KIMIA KADAR ABU DAN GLUTEN PADA TEPUNG CAKRA KEMBAR, SEGITIGA HIJAU, DAN SEGITIGA BIRU SEBAGAI BAHAN BAKU UTAMA PEMBUATAN MI INSTAN DI PT INDOFOOD CBP SUKSES MAKMUR TBK. DIVISI NOODLE CABANG SEMARANG

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Bivalirudin started during emergency transport for primary PCI.

BACKGROUND: Bivalirudin, as compared with heparin and glycoprotein IIb/IIIa inhibitors, has been shown to reduce rates of bleeding and death in patients undergoing primary percutaneous coronary intervention (PCI). Whether these benefits persist in contemporary practice characterized by prehospital initiation of treatment, optional use of glycoprotein IIb/IIIa inhibitors and novel P2Y12 inhibitors, and radial-artery PCI access use is unknown. METHODS: We randomly assigned 2218 patients with ST-segment elevation myocardial infarction (STEMI) who were being transported for primary PCI to receive either bivalirudin or unfractionated or low-molecular-weight heparin with optional glycoprotein IIb/IIIa inhibitors (control group). The primary outcome at 30 days was a composite of death or major bleeding not associated with coronary-artery bypass grafting (CABG), and the principal secondary outcome was a composite of death, reinfarction, or non-CABG major bleeding. RESULTS: Bivalirudin, as compared with the control intervention, reduced the risk of the primary outcome (5.1% vs. 8.5%; relative risk, 0.60; 95% confidence interval [CI], 0.43 to 0.82; P=0.001) and the principal secondary outcome (6.6% vs. 9.2%; relative risk, 0.72; 95% CI, 0.54 to 0.96; P=0.02). Bivalirudin also reduced the risk of major bleeding (2.6% vs. 6.0%; relative risk, 0.43; 95% CI, 0.28 to 0.66; P<0.001). The risk of acute stent thrombosis was higher with bivalirudin (1.1% vs. 0.2%; relative risk, 6.11; 95% CI, 1.37 to 27.24; P=0.007). There was no significant difference in rates of death (2.9% vs. 3.1%) or reinfarction (1.7% vs. 0.9%). Results were consistent across subgroups of patients. CONCLUSIONS: Bivalirudin, started during transport for primary PCI, improved 30-day clinical outcomes with a reduction in major bleeding but with an increase in acute stent thrombosis. (Funded by the Medicines Company; EUROMAX ClinicalTrials.gov number, NCT01087723.)

Investigation about the effect of manufacturing parameters on the mechanical behaviour of natural fibre nonwovens reinforced thermoplastic composites

To date, nonwoven fabrics made with natural fibres and thermoplastic commingled fibres have been extensively used in the composite industry for a wide variety of applications. This paper presents an innovative study about the effect of the manufacturing parameters on the mechanical behaviour of flax/PP nonwoven reinforced composites. The mechanical properties of nonwoven fabric reinforced composites are related directly to the ones of dry nonwoven reinforcements, which depend strongly on the nonwoven manufacturing parameters, such as the needle-punching and areal densities. Consequently, the influence of these manufacturing parameters will be analysed through the tensile and flexural properties. The results demonstrated that the more areal density the nonwoven fabric has, the more the mechanical behaviour can be tested for composites. By contrast, it has a complex influence on needle-punching density on the load-strain and bending behaviours at the composite scale

Nouvelle approche de modélisation de milieux poreux. Application à l'os trabéculaire

Dans de nombreux domaines tels que la science des matériaux ou l'imagerie médicale, il est intéressant d'évaluer les propriétés mécaniques d'une structure. Pour ce faire, l'analyse par éléments finis est souvent utilisée. Cependant, son application à des milieux poreux complexes est limitée, car le nombre d'éléments nécessaires pour représenter la structure interne est très grand. Dans cette communication, nous proposons une nouvelle approche par éléments finis qui prend en compte la topologie de la structure étudiée. Pour cela, nous implémentons et améliorons une technique récente basée sur le squelette 3D, permettant de caractériser des milieux poreux complexes. Chaque travée de la structure interne peut alors être représentée par une chaîne de poutres rectilignes auxquelles sont attribuées les propriétés de l'arche. Cette approche permet de réduire considérablement le temps de calcul nécessaire à la simulation mécanique par éléments finis tout en présentant une bonne adéquation avec une technique de référence. Nous avons évalué cette technique sur des vecteurs de test, puis appliqué notre méthode sur des échantillons d'os trabéculaire afin d'en quantifier précisément l'élasticité. Ce nouveau procédé de modélisation donne de meilleurs résultats de rigidité par rapport aux techniques à éléments poutre existantes sur des vecteurs de test. Cette tendance se confirme également lors de son application à l'étude de la microarchitecture de l'os trabéculaire

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of TBK1. TBK1 and DDX3X acted synergistically in their ability to stimulate the IFN promoter, whereas RNAi-mediated reduction of DDX3X expression led to an impairment of IFN production. Chromatin immunoprecipitation indicated that DDX3X is recruited to the IFN promoter upon infection with Listeria monocytogenes, suggesting a transcriptional mechanism of action. DDX3X was found to be a TBK1 substrate in vitro and in vivo. Phosphorylation-deficient mutants of DDX3X failed to synergize with TBK1 in their ability to stimulate the IFN promoter. Overall, our data imply that DDX3X is a critical effector of TBK1 that is necessary for type I IFN induction