94 research outputs found
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Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.
Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of aging in vulnerable regions of the brain, such as the hippocampus. The dynamic post-translational modification O-linked N-Acetylglucosamine (O-GlcNAc) has emerged as an attractive target for regulating aging-specific synaptic alterations as well as neurodegeneration. While speculation exists about the role of O-GlcNAc in neurodegenerative conditions, such as Alzheimer's disease, its role in physiological brain aging remains largely unexplored. Here, we report that countering age-related decreased O-GlcNAc transferase (OGT) expression and O-GlcNAcylation ameliorates cognitive impairments in aged mice. Mimicking an aged condition in young adults by abrogating OGT, using a temporally controlled neuron-specific conditional knockout mouse model, recapitulated cellular and cognitive features of brain aging. Conversely, overexpressing OGT in mature hippocampal neurons using a viral-mediated approach enhanced associative fear memory in young adult mice. Excitingly, in aged mice overexpressing neuronal OGT in the aged hippocampus rescued in part age-related impairments in spatial learning and memory as well as associative fear memory. Our data identify O-GlcNAcylaton as a key molecular mediator promoting cognitive rejuvenation
BioScore: A tool to assess the impacts of European Community policies on Europe's biodiversity
BioScore offers a European biodiversity impact assessment tool. The tool contains indicator values on the ecological preferences of more than 1000 species of birds, mammals, amphibians, reptiles, fish, butterflies, dragonflies, aquatic macro-invertebrates and vascular plants. These values are linked to policy-related pressures and environmental variables
Glossaire illustrĂ© sur les formes dâaltĂ©ration de la pierre
The ICOMOS International Scientific Committee for
Stone (ISCS) is providing a forum for the interchange of
experience, ideas, and knowledge in the field of stone
conservation. ISCS aims at facilitating the publication,
dissemination and presentation of state of the art
reviews on pre-identified issues. Simplification and
demystification of scientific information for practitioners are also part of the main goals of the group.
In studies on stone deterioration and conservation, terminological confusions lead to major communication
problems between scientists, conservators and practitioners. In this context, it is of primary importance to set
up a common language; if degradation patterns can be
shown, named and described, then they can be recognised and compared with similar ones in a more accurate
way in further investigations.
The ISCS glossary constitutes an important tool for
scientific discussions on decay phenomena and processes. It is also an excellent basis for tutorials on stone
deterioration. It is based on the careful examination of
pre-existing glossaries of English terms. It does not aim
at replacing these glossaries, often set up originally in a
language other than English, and for most of them done
to a high standard.
As President of ICOMOS I would like to congratulate the
International Scientific Committee for Stone and its
President VĂ©ronique Verges-Belmin for the results of
years of research presented in this publication. Stone
conservation is a crucial topic in monument conservation and many of our National Committees all over the
world hope for advice and help from the specialists
familiar with traditional and modern methods of
conservation. The Illustrated Glossary on Stone
Deterioration Patterns offers a wide range of suggestions and practical advice. Probably, after the English-French version becomes available the Glossary will also
be translated into other languages. In view of the accelerating decay of our stone monuments worldwide this
is an exemplary contribution which will promote the
international cooperation so important in this field.peer-reviewe
Neue Vogelarten aus Amazonien
Volume: 22Start Page: 39End Page: 4
Neue Vogelarten aus Amazonien
Volume: 20Start Page: 153End Page: 15
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