Cerebral microdialysis: research technique or clinical tool

Cerebral microdialysis is a well-established laboratory tool that is increasingly used as a bedside monitor to provide on-line analysis of brain tissue biochemistry during neuro-intensive care. This review describes the principles of cerebral microdialysis and the rationale for its use in the clinical setting, including discussion of the most commonly used microdialysis biomarkers of acute brain injury. Potential clinical applications are reviewed and future research applications identified. Microdialysis has the potential to become an established part of mainstream multimodality monitoring during the management of acute brain injury but at present should be considered a research tool for use in specialist centres

Halite and stable chlorine isotopes in the Zag H3-6 breccia

Zag is an H3-6 chondrite regolith breccia within which we have studied 14 halite grains ?3mm. The purity of the associated NaCl-H2O brine is implied by freezing characteristics of fluid inclusions in the halite and EPMA analyses together with a lack of other evaporite-like phases in the Zag H3-6 component. This is inconsistent with multistage evolution of the fluid involving scavenging of cations in the Zag region of the parent body. We suggest that the halite grains are clastic and did not crystallise in situ. Halite and water-soluble extracts from Zag have light Cl isotopic compositions, ?37-Cl = -1.4 to '2.8 �. Previously reported bulk carbonaceous chondrite values are approximately ?37-Cl = +3 to +4 �. This difference is too great to be the result of fractionation during evaporation and instead we suggest that Cl isotopes in chondrites are fractionated between a light reservoir associated with fluids and a heavier reservoir associated with higher temperature phases such as phosphates and silicates. Extraterrestrial carbon released at 600 degrees Celsius from the H3-4 matrix has ?13-C = -20 �, consistent with poorly graphitised material being introduced into the matrix rather than indigenous carbonate derived from a brine. We have also examined 28 other H-chondrite falls in order to ascertain how widespread halite or evaporite-like mineral assemblages are in ordinary chondrites. We did not find any more to add to Zag (H3-6) and Monahans (H5), which suggests that such highly soluble phases were not usually preserved on the parent bodies

Cutting blade dentitions in squaliform sharks form by modification of inherited alternate tooth ordering patterns

The squaliform sharks represent one of the most speciose shark clades. Many adult squaliforms have blade-like teeth, either on both jaws or restricted to the lower jaw, forming a continuous, serrated blade along the jaw margin. These teeth are replaced as a single unit and successor teeth lack the alternate arrangement present in other elasmobranchs. Micro-CT scans of embryos of squaliforms and a related outgroup (Pristiophoridae) revealed that the squaliform dentition pattern represents a highly modified version of tooth replacement seen in other clades. Teeth of Squalus embryos are arranged in an alternate pattern, with successive tooth rows containing additional teeth added proximally. Asynchronous timing of tooth production along the jaw and tooth loss prior to birth cause teeth to align in oblique sets containing teeth from subsequent rows; these become parallel to the jaw margin during ontogeny, so that adult Squalus has functional tooth rows comprising obliquely stacked teeth of consecutive developmental rows. In more strongly heterodont squaliforms, initial embryonic lower teeth develop into the oblique functional sets seen in adult Squalus, with no requirement to form, and subsequently lose, teeth arranged in an initial alternate pattern

Low cost vision based personal mobile mapping system

Mobile mapping systems (MMS) can be used for several purposes, such as transportation, highway infrastructure mapping and GIS data collecting. However, the acceptance of these systems is not wide spread and their use is still limited due the high cost and dependency on the Global Navigation Satellite System (GNSS). A low cost vision based personal MMS has been produced with an aim to overcome these limitations. The system has been designed to depend mainly on cameras and use of low cost GNSS and inertial sensors to provide a bundle adjustment solution with initial values. The system has the potential to be used indoor and outdoor. The system has been tested indoors and outdoors with different GPS coverage, surrounded features, and narrow and curvy paths. Tests show that the system is able to work in such environments providing 3D coordinates of better than 10 cm accuracy

Magnetoroton instabilities and static susceptibilities in higher Landau levels

We present analytical results concerning the magneto-roton instability in higher Landau levels evaluated in the single mode approximation. The roton gap appears at a finite wave vector, which is approximately independent of the LL index n, in agreement with numerical calculations in the composite-fermion picture. However, a large maximum in the static susceptibility indicates a charge density modulation with wave vectors $q_0(n)\sim 1/\sqrt{2n+1}$, as expected from Hartree-Fock predictions. We thus obtain a unified description of the leading charge instabilities in all LLs.Comment: 4 pages, 5 figure

Signature of stripe pinning in optical conductivity

The response of charge stripes to an external electric field applied perpendicular to the stripe direction is studied within a diagrammatic approach for both weak and strong pinning by random impurities. The sound-like mode of the stripes described as elastic strings moves to finite frequency due to impurity pinning. By calculating the optical conductivity we determine this characteristic energy scale for both a single stripe and an array of interacting stripes. The results explain the anomalous far-infrared peak observed recently in optical-conductivity measurements on cuprates.Comment: Revised version, to appear in Phys. Rev.

Are Antiprotons Forever?

Up to one million antiprotons from a single LEAR spill have been captured in a large Penning trap. Surprisingly, when the antiprotons are cooled to energies significantly below 1 eV, the annihilation rate falls below background. Thus, very long storage times for antiprotons have been demonstrated in the trap, even at the compromised vacuum conditions imposed by the experimental set up. The significance for future ultra-low energy experiments, including portable antiproton traps, is discussed.Comment: 12 pages, latex; 4 figures, uufiled. Slightly expanded discussion of expected energy dependence of annihilation cross section and rate, and of estimates of trap pressure, plus minor text improvement

Reddening law and interstellar dust properties along Magellanic sight-lines

This study establishes that SMC, LMC and Milky Way extinction curves obey the same extinction law which depends on the 2200A bump size and one parameter, and generalizes the Cardelli, Clayton and Mathis (1989) relationship. This suggests that extinction in all three galaxies is of the same nature. The role of linear reddening laws over all the visible/UV wavelength range, particularly important in the SMC but also present in the LMC and in the Milky Way, is also highlighted and discussed.Comment: accepted for publication in Astrophysics and Space Science. 16 pages, 12 figures. Some figures are colour plot