Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer.

Pregnancy-associated breast cancers (PABCs) are tumors diagnosed during pregnancy or up to 5 years following parturition, and are usually high-grade, connective tissue-rich, and estrogen receptor (ER)/progesterone receptor-negative. Little is known about the cellular origin of PABCs or the mechanisms by which PABCs are initiated. Using the RCAS retrovirus to deliver the ErbB2 oncogene into the mammary epithelium of our previously reported MMTV-tva transgenic mice, we detected high-grade, poorly differentiated, stroma-rich and ER-negative tumors during pregnancy and lactation. These high-grade and stroma-rich tumors were less frequent in involuted mice or in age-matched nulliparous mice. More importantly, by generating a WAP-tva transgenic line for expression of ErbB2 selectively in WAP(+) mammary alveolar cells, we found that tumors had similar morphological phenotypes (high grade, poorly differentiated, stroma-rich and ER-negative), irrespective of the time since pregnancy and even in the absence of pregnancy. These data suggest that PABCs arise preferentially from an alveolar cell population that expands during pregnancy and lactation. This somatic mouse model may also be useful for preclinical testing of new prophylactic and therapeutic strategies against PABC

Providing distributed certificate authority service in mobile ad hoc networks

In this paper, we propose an architecture for providing distributed Certificate Authority (CA) service in Mobile Ad Hoc Networks (MANET), based on threshold cryptography. We have two major contributions: 1) we make use of the cluster structure to provide CA service, and design a scheme for locating CA server nodes in MANET; 2) we provide a proactive secret share update protocol, which periodically updates CA secret shares with low system overhead. Compared with existing approaches, our CA architecture provides faster CA services to user nodes at reduced system overhead. © 2005 IEEE.published_or_final_versio

Developing a Data-driven School Building Stock Energy and Indoor Environmental Quality Modelling Method

The school building sector has a pivotal role to play in the transition to a low carbon UK economy. School buildings are responsible for 15% of the country’s public sector carbon emissions, with space heating currently making up the largest proportion of energy use and associated costs in schools. Children spend a large part of their waking life in school buildings. There is substantial evidence that poor indoor air quality and thermal discomfort can have detrimental impacts on the performance, wellbeing and health of schoolchildren and school staff. Maintaining high indoor environmental quality whilst reducing energy demand and carbon emissions in schools is challenging due to the unique operational characteristics of school environments, e.g. high and intermittent occupancy densities or changes in occupancy patterns throughout the year. Furthermore, existing data show that 81% of the school building stock in England was constructed before 1976. Challenges facing the ageing school building stock may be exacerbated in the context of ongoing and future climate change. In recent decades, building stock modelling has been widely used to quantify and evaluate the current and future energy and indoor environmental quality performance of large numbers of buildings at the neighbourhood, city, regional or national level. Building stock models commonly use building archetypes, which aim to represent the diversity of building stocks through frequently occurring building typologies. The aim of this paper is to introduce the Data dRiven Engine for Archetype Models of Schools (DREAMS), a novel, data-driven, archetype-based school building stock modelling framework. DREAMS enables the detailed representation of the school building stock in England through the statistical analysis of two large scale and highly detailed databases provided by the UK Government: (i) the Property Data Survey Programme (PDSP) from the Department for Education (DfE), and (ii) Display Energy Certificates (DEC). In this paper, the development of 168 building archetypes representing 9,551 primary schools in England is presented. The energy consumption of the English primary school building stock was modelled for a typical year under the current climate using the widely tested and applied building performance software EnergyPlus. For the purposes of modelling validation, the DREAMS space heating demand predictions were compared against average measured energy consumption of the schools that were represented by each archetype. It was demonstrated that the simulated fossil-thermal energy consumption of a typical primary school in England was only 7% higher than measured energy consumption (139 kWh/m2/y simulated, compared to 130 kWh/m2/y measured). The building stock model performs better at predicting the energy performance of naturally ventilated buildings,which constitute 97% of the stock, than that of mechanically ventilated ones. The framework has also shown capabilities in predicting energy consumption on a more localised scale. The London primary school building stock was examined as a case study. School building stock modelling frameworks such as DREAMS can be powerful tools that aid decision-makers to quantify and evaluate the impact of a wide range of building stock-level policies, energy efficiency interventions and climate change scenarios on school energy and indoor environmental performance

Modelling platform for schools (MPS): The development of an automated One-By-One framework for the generation of dynamic thermal simulation models of schools

The UK Government has recently committed to achieve net zero carbon status by year 2050. Schools are responsible for around 2% of the UK’s total energy consumption, and around 15% of the UK public sector’s carbon emissions. A detailed analysis of the English school building stock’s performance can help policymakers improve its energy efficiency and indoor environmental quality. Building stock modelling is a technique commonly used to quantify current and future energy demand or indoor environmental quality performance of large numbers of buildings at the neighbourhood, city, regional or national level. ‘Building-by-building’ stock modelling is a modelling technique whereby individual buildings within the stock are modelled and simulated, and performance results are aggregated and analysed at stock level. This paper presents the development of the Modelling Platform for Schools (MPS) – an automated generation of one-by-one thermal models of schools in England through the analysis and integration of a range of data (geometry, size, number of buildings within a school premises etc.) from multiple databases and tools (Edubase/Get Information About Schools, Property Data Survey Programme, Ordanance Survey and others). The study then presents an initial assessment and evaluation of the modelling procedure of the proposed platform. The model evaluation has shown that out of 15,245 schools for which sufficient data were available, nearly 50% can be modelled in an automated manner having a high level of confidence of similarity with the actual buildings. Visual comparison between automatically-generated models and actual buildings has shown that around 70% of the models were, indeed, geometrically accurate

Residual stress analysis and finite element modelling of repair-welded titanium sheets

An innovative FE modelling approach has been tested to investigate the effects of weld repair thin sheets of titanium alloy, taking into account pre-existing stress field in the components. In the case study analysed, the residual stress fields due to the original welds are introduced by means of a preliminary sequentially-coupled thermo-mechanical analysis and considered as pre-existing stress in the sheets for the subsequent weld simulation. Comparisons are presented between residual stress predictions and experimental measurements available from the literature with the aim of validating the numerical procedure. As a destructive sectioning technique was used in the reference experimental measurements, an investigation is also presented on the use of the element deactivation strategy when adopted to simulate material removal. Although the numerical tool is an approximate approach to simulate the actual material removal, the strategy appears to compute a physical strain relaxation and stress redistribution in the remaining part of the component. The weld repair modelling strategy and the element deactivation tool adopted to simulate the residual stress measurement technique are shown to predict residual stress trends which are very well correlated with experimental findings from the literature

Indoor Air Quality and Overheating in UK Classrooms – an Archetype Stock Modelling Approach

Children spend a large part of their waking lives in school buildings. There is substantial evidence that poor indoor air quality (IAQ) and thermal discomfort can have detrimental impacts on the performance, wellbeing and health of schoolchildren and staff. Maintaining good IAQ while avoiding overheating in classrooms is challenging due to the unique occupancy patterns and heat properties of schools. Building stock modelling has been extensively used in recent years to quantify and evaluate performance of large numbers of buildings at various scales. This paper builds on an archetype stock modelling approach which represents the diversity of the school stock in England through an analysis of The Property Data Survey Programme (PDSP) and the Display Energy Certificates (DEC) databases. The model was used for simulating Indoor-to-Outdoor pollution ratios to estimate indoor air pollution levels (NO2, PM2.5 and CO2) and thermal comfort (overheating) in two climate areas in England: London and the West Pennines. analysis highlighted variations in classrooms' indoor CO2 levels in different seasons and explored the risk of overheating in relation to a classroom's orientation

Imbalanced functional link between executive control network and reward network explain the online-game seeking behaviors in Internet gaming disorder

Literatures have shown that Internet gaming disorder (IGD) subjects show impaired executive control and enhanced reward sensitivities than healthy controls. However, how these two networks jointly affect the valuation process and drive IGD subjects' online-game-seeking behaviors remains unknown. Thirty-five IGD and 36 healthy controls underwent a resting-states scan in the MRI scanner. Functional connectivity (FC) was examined within control and reward network seeds regions, respectively. Nucleus accumbens (NAcc) was selected as the node to find the interactions between these two networks. IGD subjects show decreased FC in the executive control network and increased FC in the reward network when comparing with the healthy controls. When examining the correlations between the NAcc and the executive control/reward networks, the link between the NAcc - executive control network is negatively related with the link between NAcc - reward network. The changes (decrease/increase) in IGD subjects' brain synchrony in control/reward networks suggest the inefficient/overly processing within neural circuitry underlying these processes. The inverse proportion between control network and reward network in IGD suggest that impairments in executive control lead to inefficient inhibition of enhanced cravings to excessive online game playing. This might shed light on the mechanistic understanding of IGD

Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B

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Dirac Equation with Spin Symmetry for the Modified P\"oschl-Teller Potential in DD-dimensions

We present solutions of the Dirac equation with spin symmetry for vector and scalar modified P\"oschl-Teller potential within framework of an approximation of the centrifugal term. The relativistic energy spectrum is obtained using the Nikiforov-Uvarov method and the two-component spinor wavefunctions are obtain are in terms of the Jacobi polynomials. It is found that there exist only positive-energy states for bound states under spin symmetry, and the energy levels increase with the dimension and the potential range parameter $\alpha$.Comment: 9 pages and 1tabl