Angular momentum transport, layering, and zonal jet formation by the GSF instability: non-linear simulations at a general latitude

We continue our investigation into the non-linear evolution of the Goldreich–Schubert–Fricke (GSF) instability in differentially rotating radiation zones. This instability may be a key player in transporting angular momentum in stars and giant planets, but its non-linear evolution remains mostly unexplored. In a previous paper we considered the equatorial instability, whereas here we simulate the instability at a general latitude for the first time. We adopt a local Cartesian Boussinesq model in a modified shearing box for most of our simulations, but we also perform some simulations with stress-free, impenetrable, radial boundaries. We first revisit the linear instability and derive some new results, before studying its non-linear evolution. The instability is found to behave very differently compared with its behaviour at the equator. In particular, here we observe the development of strong zonal jets (‘layering’ in the angular momentum), which can considerably enhance angular momentum transport, particularly in axisymmetric simulations. The jets are, in general, tilted with respect to the local gravity by an angle that corresponds initially with that of the linear modes, but which evolves with time and depends on the strength of the flow. The instability transports angular momentum much more efficiently (by several orders of magnitude) than it does at the equator, and we estimate that the GSF instability could contribute to the missing angular momentum transport required in both red giant and subgiant stars. It could also play a role in the long-term evolution of the solar tachocline and the atmospheric dynamics of hot Jupiters

Tailoring the Optical Dipole Force for Molecules by Field-Induced Alignment

We report on the ability to tailor the optical dipole force for molecules by tuning their effective polarizability with strong field alignment using polarized fields. We have measured a difference of 20% in the dipole force on cold CS2 molecules when changing from linear to near-circular polarization using peak field intensities of 5.7×1011  W cm-2. A variation in the focal length with laser polarization of a molecular-optical lens formed by a single focused laser beam was also measured. This provides a new way of modifying this force for many molecules

Angular momentum transport by the GSF instability: non-linear simulations at the equator

We present an investigation into the non-linear evolution of the Goldreich–Schubert–Fricke (GSF) instability using axisymmetric and 3D simulations near the equator of a differentially rotating radiation zone. This instability may provide an important contribution to angular momentum transport in stars and planets. We adopt a local Boussinesq Cartesian shearing box model, which represents a small patch of a differentially rotating stellar radiation zone. Complementary simulations are also performed with stress-free, impenetrable boundaries in the local radial direction. The linear and non-linear evolution of the equatorial axisymmetric instability is formally equivalent to the salt fingering instability. This is no longer the case in 3D, but we find that the instability behaves non-linearly in a similar way to salt fingering. Axisymmetric simulations – and those in 3D with short dimensions along the local azimuthal direction – quickly develop strong jets along the rotation axis, which inhibit the instability and lead to predator-prey-like temporal dynamics. In 3D, the instability initially produces homogeneous turbulence and enhanced momentum transport, though in some cases jets form on a much longer time-scale. We propose and validate numerically a simple theory for non-linear saturation of the GSF instability and its resulting angular momentum transport. This theory is straightforward to implement in stellar evolution codes incorporating rotation. We estimate that the GSF instability could contribute towards explaining the missing angular momentum transport required in red giant stars, and play a role in the long-term evolution of the solar tachocline

Alcohol based surgical prep solution and the risk of fire in the operating room: a case report

A few cases of fire in the operating room are reported in the literature. The factors that may initiate these fires are many and include alcohol based surgical prep solutions, electrosurgical equipment, flammable drapes etc. We are reporting a case of fire in the operating room while operating on a patient with burst fracture C6 vertebra with quadriplegia. The cause of the fire was due to incomplete drying of the covering drapes with an alcohol based surgical prep solution. This paper discusses potential preventive measures to minimize the incidence of fire in the operating room

Defining PD subtypes — a step toward personalized management?

A recent article published in Brain proposes a clinical method for subtyping Parkinson disease cases on an individual basis, with implications for better patient stratification for personalized medicine. The authors report biological validity in terms of imaging and cerebrospinal fluid parameters, but long-term predictive validity remains to be established.The work of the authors is supported by the NIHR Cambridge Biomedical Research Centre and the Wellcome Trust–Medical Research Council Cambridge Stem Cell Institute

Diffusion tensor imaging of Parkinson's disease, multiple system atrophy and progressive supranuclear palsy: a tract-based spatial statistics study

Although often clinically indistinguishable in the early stages, Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, cerebral peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and cerebral peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this study we have addressed this by investigating the immediate effects of WNT signalling activation within the stomach epithelium. We have specifically activated the WNT signalling pathway within the mouse adult gastric epithelium via deletion of either glycogen synthase kinase 3 (GSK3) or APC or via expression of a constitutively active β-catenin protein. WNT pathway deregulation dramatically affects stomach homoeostasis at very short latencies. In the corpus, there is rapid loss of parietal cells with fundic gland polyp (FGP) formation and adenomatous change, which are similar to those observed in familial adenomatous polyposis. In the antrum, adenomas occur from 4 days post-WNT activation. Taken together, these data show a pivotal role for WNT signalling in gastric homoeostasis, FGP formation and adenomagenesis. Loss of the parietal cell population and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral adenoma formation are immediate effects of nuclear β-catenin translocation and WNT target gene expression. Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach

Simpson's Paradox, Lord's Paradox, and Suppression Effects are the same phenomenon – the reversal paradox

This article discusses three statistical paradoxes that pervade epidemiological research: Simpson's paradox, Lord's paradox, and suppression. These paradoxes have important implications for the interpretation of evidence from observational studies. This article uses hypothetical scenarios to illustrate how the three paradoxes are different manifestations of one phenomenon – the reversal paradox – depending on whether the outcome and explanatory variables are categorical, continuous or a combination of both; this renders the issues and remedies for any one to be similar for all three. Although the three statistical paradoxes occur in different types of variables, they share the same characteristic: the association between two variables can be reversed, diminished, or enhanced when another variable is statistically controlled for. Understanding the concepts and theory behind these paradoxes provides insights into some controversial or contradictory research findings. These paradoxes show that prior knowledge and underlying causal theory play an important role in the statistical modelling of epidemiological data, where incorrect use of statistical models might produce consistent, replicable, yet erroneous results

Adjacent level discitis after anterior cervical discectomy and fusion (ACDF): a case report

This report describes a case of spondylodiscitis occurring adjacent to levels at which anterior cervical discectomy and fusion was performed. The objective is to describe a rare cause of spondylodiscitis and discuss its successful management. Post-operative discitis involving the same level is a known occurrence. We report an interesting case of spondylodiscitis occurring at the adjacent level of fusion, and to our knowledge this is the first such case reported in literature. A two-level decompression and fusion was performed at C5–6 and C6–7 levels with PEEK cages and anterior cervical plating in a middle-aged gentleman for persistent axial neck pain and left-sided radiculopathy involving C6 and C7 distribution. After 6 weeks, the patient presented to us with complaints of mild paresthesia in the abdomen and extremities. Radiological investigations including plain radiographs and MRI revealed a surprising finding of discitis at C4–5 level with an associated epidural abscess. In view of the patient’s myelopathic symptoms, surgical debridement and decompression of the spinal cord was performed. The plate and screws were removed, the cages were left intact, and the C4–5 disc level was reconstructed with tricortical iliac crest autograft. No further instrumentation was performed. The biopsy specimen from the disc at C4–5 level grew Serratia marcescens. It was contemplated that C4–5 discitis was initiated by inoculation of bacteria at the superior endplate of C5 by contaminated vertebral pins/drill-bit or screws. Adjacent level discitis is a rare but potentially serious complication of anterior cervical fusion. A high index of suspicion of infection is necessary if the patient complains of new symptoms after anterior cervical fusion. Thorough assessment and aggressive treatment is necessary for successful management