6,072 research outputs found
Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure
Introduction. The relation between minute ventilation (VE) and carbon dioxide production (VCO2) can be characterised by the instantaneous ratio of ventilation to carbon dioxide production, the ventilatory equivalent for CO2 (VEqCO2). We hypothesised that the time taken to achieve the lowest VEqCO2 (time to VEqCO2 nadir) may be a prognostic marker in patients with chronic heart failure (CHF). Methods. Patients and healthy controls underwent a symptom-limited, cardiopulmonary exercise test (CPET) on a treadmill to volitional exhaustion. Results. 423 patients with CHF (mean age 63±12 years; 80% males) and 78 healthy controls (62% males; age 61±11 years) were recruited. Time to VEqCO2 nadir was shorter in patients than controls (327±204 s versus 514±187 s; P=0.0001). Univariable predictors of all-cause mortality included peak oxygen uptake (X 2 =53.0), VEqCO2 nadir (X 2 =47.9), and time to VEqCO2 nadir (X 2 =24.0). In an adjusted Cox multivariable proportional hazards model, peak oxygen uptake (X 2 =16.7) and VEqCO2 nadir (X 2 =17.9) were the most significant independent predictors of all-cause mortality. Conclusion. The time to VEqCO2 nadir was shorter in patients with CHF than in normal subjects and was a predictor of subsequent mortality. © 2012 Lee Ingle et al
Stringent Phenomenological Investigation into Heterotic String Optical Unification
For the weakly coupled heterotic string (WCHS) there is a well-known factor
of twenty conflict between the minimum string coupling unification scale,
Lambda_H ~5x10^(17) GeV, and the projected MSSM unification scale, Lambda_U ~
2.5x10^(16) GeV, assuming an intermediate scale desert (ISD). Renormalization
effects of intermediate scale MSSM-charged exotics (ISME) (endemic to
quasi-realistic string models) can resolve this issue, pushing the MSSM scale
up to the string scale. However, for a generic string model, this implies that
the projected Lambda_U unification under ISD is accidental. If the true
unification scale is 5.0x10^(17) GeV, is it possible that illusionary
unification at 2.5x10^(17) GeV in the ISD scenario is not accidental? If it is
not, then under what conditions would the assumption of ISME in a WCHS model
imply apparent unification at Lambda_U when ISD is falsely assumed? Geidt's
"optical unification" suggests that Lambda_U is not accidental, by offering a
mechanism whereby a generic MSSM scale Lambda_U < Lambda_H is guaranteed. A
WCHS model was constructed that offers the possibility of optical unification,
depending on the availability of anomaly-cancelling flat directions meeting
certain requirements. This paper reports on the systematic investigation of the
optical unification properties of the set of stringent flat directions of this
model. Stringent flat directions can be guaranteed to be F-flat to all finite
order (or to at least a given finite order consistent with electroweak scale
supersymmetry breaking) and can be viewed as the likely roots of more general
flat directions. Analysis of the phenomenology of stringent flat directions
gives an indication of the remaining optical unification phenomenology that
must be garnered by flat directions developed from them.Comment: standard latex, 18 pages of tex
Nanotube field of C60 molecules in carbon nanotubes: atomistic versus continuous tube approach
We calculate the van der Waals energy of a C60 molecule when it is
encapsulated in a single-walled carbon nanotube with discrete atomistic
structure. orientational degrees of freedom and longitudinal displacements of
the molecule are taken into account, and several achiral and chiral carbon
nanotubes are considered. A comparison with earlier work where the tube was
approximated by a continuous cylindrical distribution of carbon atoms is made.
We find that such an approximation is valid for high and intermediate tube
radii; for low tube radii, minor chirality effects come into play. Three
molecular orientational regimes are found when varying the nanotube radius.Comment: 14 pages, 9 figures, accepted for publication in Phys. Rev.
Preliminary tests of a new low-cost photogrammetric system
This paper presents preliminary tests of a new low-cost photogrammetric system for 4D modelling of large scale areas for civil engineering applications. The system consists of five stand-alone units. Each of the units is composed of a Raspberry Pi 2 Model B (RPi2B) single board computer connected to a PiCamera Module V2 (8 MP) and is powered by a 10 W solar panel. The acquisition of the images is performed automatically using Python scripts and the OpenCV library. Images are recorded at different times during the day and automatically uploaded onto a FTP server from where they can be accessed for processing. Preliminary tests and outcomes of the system are discussed in detail. The focus is on the performance assessment of the low-cost sensor and the quality evaluation of the digital surface models generated by the low-cost photogrammetric systems in the field under real test conditions. Two different test cases were set up in order to calibrate the low-cost photogrammetric system and to assess its performance. First comparisons with a TLS model show a good agreement
PRELIMINARY TESTS OF A NEW LOW-COST PHOTOGRAMMETRIC SYSTEM
This paper presents preliminary tests of a new low-cost photogrammetric system for 4D modelling of large scale areas for civil engineering applications. The system consists of five stand-alone units. Each of the units is composed of a Raspberry Pi 2 Model B (RPi2B) single board computer connected to a PiCamera Module V2 (8 MP) and is powered by a 10 W solar panel. The acquisition of the images is performed automatically using Python scripts and the OpenCV library. Images are recorded at different times during the day and automatically uploaded onto a FTP server from where they can be accessed for processing. Preliminary tests and outcomes of the system are discussed in detail. The focus is on the performance assessment of the low-cost sensor and the quality evaluation of the digital surface models generated by the low-cost photogrammetric systems in the field under real test conditions. Two different test cases were set up in order to calibrate the low-cost photogrammetric system and to assess its performance. First comparisons with a TLS model show a good agreement
Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1
Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation
Carbon-rich dust production in metal-poor galaxies in the Local Group
We have observed a sample of 19 carbon stars in the Sculptor, Carina, Fornax,
and Leo I dwarf spheroidal galaxies with the Infrared Spectrograph on the
Spitzer Space Telescope. The spectra show significant quantities of dust around
the carbon stars in Sculptor, Fornax, and Leo I, but little in Carina. Previous
comparisons of carbon stars with similar pulsation properties in the Galaxy and
the Magellanic Clouds revealed no evidence that metallicity affected the
production of dust by carbon stars. However, the more metal-poor stars in the
current sample appear to be generating less dust. These data extend two known
trends to lower metallicities. In more metal-poor samples, the SiC dust
emission weakens, while the acetylene absorption strengthens. The bolometric
magnitudes and infrared spectral properties of the carbon stars in Fornax are
consistent with metallicities more similar to carbon stars in the Magellanic
Clouds than in the other dwarf spheroidals in our sample. A study of the carbon
budget in these stars reinforces previous considerations that the dredge-up of
sufficient quantities of carbon from the stellar cores may trigger the final
superwind phase, ending a star's lifetime on the asymptotic giant branch.Comment: ApJ, in press, 21 pages, 12 figures. Replaced Fig 12, corrected two
reference
The Relationships Between School Poverty and Student Achievement in Maine
The goal of this study was to examine the relationships between school level poverty found in Maine schools and student academic performance. The evidence clearly shows that there is a relationship. As the percent of poverty increases in a school, student performance declines. But the poverty level alone does not explain the wide variations in performance found across the state. The level of poverty in a school is the single best predictor of average student performance, but other factors also play a role in influencing student achievement. Some of these factors include the type of school students are enrolled in, years of teaching experience of the school staff, and the education levels of teachers. Evidence was also found for some higher poverty schools that were defying the odds. Even with higher levels of poverty in their schools, these schools were successful in producing higher levels of student performance. Two additional characteristics were discovered for student performance in higher poverty schools. First, overall performance differs in K-8 and middle schools. The negative relationship between poverty levels and performance is weaker for K-8 schools. More of the higher poverty K-8 schools are performing better than higher poverty middle schools. Second, the levels of poverty found in schools not only affected children in poverty but also those not in poverty. Students in higher poverty schools who do not qualify for free or reduced lunches do not perform as well as their cohorts in lower poverty schools. What is unclear are the causes of this lower performance of non-poverty children in higher poverty schools. Without question, the evidence examined in this study indicates that levels of school poverty and average student achievement are related. The magnitude of the relationship varies, and other factors are related to poverty and achievement, but the single best predictor of performance is school poverty level. The bright news is that there are schools at all levels that defy the odds. Student achievement is better than predicted in spite of school poverty levels. These schools may provide good models for other schools to emulate. In addition, the evidence from this study indicates that there is more to learn about the performance of some types of school configurations (i.e., K-8 schools) and the performance of non-poverty children in higher poverty schools. Additional numerical data is included in the appendices. [This study was funded by the Maine State Legislature, and the University of Maine System.
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