Preliminary Investigation of Antimicrobial Property of Acacia leucophloea Leaves Extract

Leaves of indigenous plant Acacia leucophloea have been successively extracted using different solvents like hexane, methanol and water. Extract was evaluated for its antibacterial activity using two assay method Kirby bauer disc diffusion and tube dilution assay. Results of the given study revealed that the methanolic extract is potential antibacterial agent specifically for E coli & & S aureus

Preliminary Investigation of Antipyretic Activity of Trinpanchmool Extracts

Current research work is to evaluate the antipyretic activity of hydro-alcoholic extract of trinpanchmool on the wistar rats. Brewer’s yeast induced pyrexia method was used to evaluate febrifuge effect of trinpanchmool extract along with its comparison with its individual constituents on the wistar rats. Darbh, Ikshu and SAR was having better antipyretic activity than the standard drug paracetamol. Combination of the drugs was having better antipyretic that paracetamol but lesser than the individual drugs. Trinpanchmool and its individual drugs are having febrifugatic effect better than our standard paracetamol

Preliminary Investigation of Antipyretic Activity of Trinpanchmool Extracts

Current research work is to evaluate the antipyretic activity of hydro-alcoholic extract of trinpanchmool on the wistar rats. Brewer’s yeast induced pyrexia method was used to evaluate febrifuge effect of trinpanchmool extract along with its comparison with its individual constituents on the wistar rats. Darbh, Ikshu and SAR was having better antipyretic activity than the standard drug paracetamol. Combination of the drugs was having better antipyretic that paracetamol but lesser than the individual drugs. Trinpanchmool and its individual drugs are having febrifugatic effect better than our standard paracetamol

Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions

Neuroblastoma (NB) is the most frequent solid tumor in pediatric cases, contributing to around 15% of childhood cancer-related deaths. The wide-ranging genetic, morphological, and clinical diversity within NB complicates the success of current treatment methods. Acquiring an in-depth understanding of genetic alterations implicated in the development of NB is essential for creating safer and more efficient therapies for this severe condition. Several molecular signatures are being studied as potential targets for developing new treatments for NB patients. In this article, we have examined the molecular factors and genetic irregularities, including those within insulin gene enhancer binding protein 1 (ISL1), dihydropyrimidinase-like 3 (DPYSL3), receptor tyrosine kinase-like orphan receptor 1 (ROR1) and murine double minute 2-tumor protein 53 (MDM2-P53) that play an essential role in the development of NB. A thorough summary of the molecular targeted treatments currently being studied in pre-clinical and clinical trials has been described. Recent studies of immunotherapeutic agents used in NB are also studied in this article. Moreover, we explore potential future directions to discover new targets and treatments to enhance existing therapies and ultimately improve treatment outcomes and survival rates for NB patients

Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine

The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored for five weeks for the period 20.10.2020–24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder-identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co-occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter-community were related to the coronavirus disease 2019 (COVID-19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility-promotion, which could be successfully utilized by healthcare-related open innovation platforms or initiatives

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events

Synthesis

Driven by the increased demand of pyrazolines exhibiting biological activities like antioxidant, anti-inflammatory, antidepressant, antimicrobial, antitumor, and antitubercular drug activity as a stable fragment in biological moieties, lead us to synthesize 2-pyrazolines by the condensation of various substituted chalcones and hydrazine hydrate in the presence of ethanol. The structure of the synthesized molecules was confirmed on the basis of physical data and extensive spectral studies. All the 13 compounds have been screened for antioxidant activity using DPPH radical scavenging method, NO scavenging assay, superoxide radical scavenging assay and hydrogen peroxide radical scavenging assay. All the compounds showed good free radical scavenging activity which is comparable to that of the standard ascorbic acid, out of which ATP-1, ATP-2 and ATP-3 come out to be the best molecules with an IC50 less than 40 mcg/ml. The results indicated that 2-pyrazolines could be the potential candidates eliciting antioxidant activity, and further studies can be conducted using molecular modeling tools for designing 2-pyrazolines having better activity

Orphan crops: A genetic treasure trove for hunting stress tolerance genes

Abstract Orphan crops, also known as minor crops, smart foods, and superfoods, have attracted great attention recently because of their unique ability to grow in resource‐poor marginal lands, and under harsh environmental conditions without any intensive agricultural care. These crops possess inherent tolerance against different abiotic stresses such as drought, salinity, cold, and heat. Recent advancements in genomic resources and high‐throughput phenotyping platforms have provided opportunities to explore the untapped potential of orphan crops to identify novel gene source(s) and mechanism(s) for developing abiotic stress‐tolerant crops. Moreover, genomics‐assisted investigations into the various physiological and molecular mechanism(s) could provide useful insights into stress tolerance mechanisms in these plants. Nevertheless, translating the hidden power of the tolerant gene pools from the orphan crops into major staple crops for enhancing their stress tolerance while maintaining yield is a challenging task. The contemporary tools of genomics can be used to unravel the secret of stress tolerance in orphan crops and employ these untapped genes for tailoring stress‐tolerant crop varieties to ensure global food security in the era of climate change

Evaluation of Antimicrobial Activity of 3-(4-1H-Indol-3-yl)-(2,3- dihydro-1H-benzo[b]diazepin-2-yl)-2H-chromen-2-one

Abstract-1,5-Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds which possess wide range of therapeutic and pharmacological properties as anticonvulsant, analgesic, sedative, antidepressive, and hypnotic agents. In the last decade, the area of biological interest of 1,5-Benzodiazepines has been extended to several diseases such as cancer, viral infection and cardiovascular disorders. With this background, we had synthesized RVB-01 (3- Structure of this compound have been elucidated by using physical and extensive spectral data. The antimicrobial activity of RVB-01 against B subtilis , P aeruginosa, E coli, M luteus, S aureus was determined by agar diffusion method at 10, 50, 500 and 1000 mcg/ml using ciprofloxacin as a reference. MIC value of RVB-01 against B subtilis was determined by tube dilution method. RVB-01 showed remarkable activity against all microorganisms except E coli and having an MIC value of 250-300 mcg/ml against B subtilis. The results indicated that 2,3-Dihydro-1H-1,5-Benzodiazepines could be the potential candidate eliciting antibacterial activity, and further studies can be conducted using molecular modeling tools for designing 1,5-benzodiazepines having better activity