36 research outputs found
The Physics of Kondo Impurities in Graphene
This article summarizes our understanding of the Kondo effect in graphene,
primarily from a theoretical perspective. We shall describe different ways to
create magnetic moments in graphene, either by adatom deposition or via
defects. For dilute moments, the theoretical description is in terms of
effective Anderson or Kondo impurity models coupled to graphene's Dirac
electrons. We shall discuss in detail the physics of these models, including
their quantum phase transitions and the effect of carrier doping, and confront
this with existing experimental data. Finally, we point out connections to
other quantum impurity problems, e.g., in unconventional superconductors,
topological insulators, and quantum spin liquids.Comment: 27 pages, 8 figs. Review article prepared for Rep. Prog. Phys. ("key
issues" section). (v2) Final version as publishe
Brain energy rescue:an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies generated in the liver and lactate derived from exercising skeletal muscle can also become important energy substrates for the brain. In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progressive, region-specific and disease-specific manner — a problem that is best characterized in Alzheimer disease, where it begins presymptomatically. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes