An economic insight into additive manufacturing system implementation

With an ever growing diffusion of Additive Manufacturing (AM) system in industrial and commercial level, as well as the direct and indirect dynamics which are being introduced resulting from its inclusion as a possible production technology on companies’ portfolio, the need to reconfigure production system and adapt the production strategy becomes even more relevant than before. There are several studies which have emphasized on the importance of a paradigm shift in order to exploit advantages of AM, not only considering changes within design and functionality of the product, but also concerning AM’s impact on the entire value chain (re)configuration. Thus, it is of crucial importance to take into consideration that for this shift to be feasible and manageable, there is a need to include both technical and managerial aspects of manufacturing. This work proposes an economic insight in order to provide a guideline for the proper evaluation of AM system implementation. © IFIP International Federation for Information Processing 2015

3D printing in COVID-19: Productivity estimation of the most promising open source solutions in emergency situations

Copyright © 2020 by the authors. The COVID-19 pandemic has caused a surge of demand for medical supplies and spare parts, which has put pressure on the manufacturing sector. As a result, 3D printing communities and companies are currently operating to ease the breakdown in the medical supply chain. If no parts are available, 3D printing can potentially be used to produce time-critical parts on demand such as nasal swabs, face shields, respirators, and spares for ventilators. A structured search using online sources and feedback from key experts in the 3D printing area was applied to highlight critical issues and to suggest potential solutions. The prescribed outcomes were estimated in terms of cost and productivity at a small and large scale. This study analyzes the number and costs of parts that can be manufactured with a single machine within 24 h. It extrapolates this potential with the number of identical 3D printers in the world to estimate the global potential that can help practitioners, frontline workers, and those most vulnerable during the pandemic. It also proposes alternative 3D printing processes and materials that can be applicable. This new unregulated supply chain has also opened new questions concerning medical certification and Intellectual property rights (IPR). There is also a pressing need to develop new standards for 3D printing of medical parts for the current pandemic, and to ensure better national resilience.Academy of Finland, grant number 325509, in the frame of project Directdigital manufacturing in health care production and operations (DiDiMinH)

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1–4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0–8·4) while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6–9·2) for males and 6·5% (5·4–7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782–3252] per 100 000 in males vs s1400 [1279–1524] per 100 000 in females), transport injuries (3322 [3082–3583] vs 2336 [2154–2535]), and self-harm and interpersonal violence (3265 [2943–3630] vs 5643 [5057–6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury

Comparing the effects of aspirin, clopidogrel and their combination on random skin flap survival in rats

Background: Random pattern flap is a common reconstructive surgery procedure but its necrosis is a challenging problem. A lot of pharmacological agents and surgical procedures have been examined for the prevention of this complication to maximize the length to width ratio of these surgical flaps. Therefore, we designed an experimental study to evaluate the effects of aspirin, clopidogrel bisulfate (Plavix) and their combination on random skin flap survival in rats.Methods: Forty male rats were randomly assigned to four equal groups. Surgery was done under general anesthesia. A random, rectangular 3×11 cm dorsal skin flap was designed, elevated and sutured back into its primary site. In group one, 100 mg/kg Aspirin and in group two, 25 mg/kg Plavix were administered orally for 7 days postoperatively. Aspirin and Plavix were co-administered in the third group for the same period of time while the control group received no medication. After 7 days, the total surface of flaps, the viable and also the necrotic parts were measured by Image J software. Mean standard deviation and analysis of variance were calculated to compare the results.Results: The mean area of flap survival was 62.49% in the control, 64.04% in Aspirin, 65.09% in Plavix and 64.06% in combination groups. No statistically significant differences were found between treatment groups and control rats.Conclusion: In this study, we found no significant differences between Aspirin, Plavix or their combination on the survival of random skin flaps

A Digital Twin for Safety and Risk Management: A Prototype for a Hydrogen High-Pressure Vessel

The term “digital twin” refers to an emerging technology that utilizes the internet of things, software simulation, and data analytics to create a digital replica of a physical object or system. Digital twins have the potential to significantly transform condition monitoring and maintenance operations. In this research, a prototype is developed consisting of hardware and software components to enable the creation of a digital twin for an industrial application. High-pressure hydrogen vessels are industrial equipment with a high safety requirement for the storage and transfer of highly flammable hydrogen. Our prototype illustrates the effectiveness of utilizing a real-time digital twin of the hydrogen high-pressure vessel for failure risk management. The Action Design Research (ADR) is used to describe the process that led to the development of the prototype.Peer reviewe

Photogrammetry and Additive Manufacturing Based Methodology for Decentralized Spare Part Production in Automotive Industry

Additive Manufacturing is becoming a suitable production process for many industries: it is based on the idea of adding material layer by layer, in opposite to traditional manufacturing processes. This technology shows advantages as design flexibility, internal logistics minimization and product customization that make it perfect to produce customized parts and all the applications where low production rates occur. The production of spare parts for classic or luxury cars is a field where Additive Manufacturing can be adopted because of low demand and relevant costs to manage stocks keeping several different parts in the after-sales inventory. The photogrammetry technique has been investigated to obtain the 3D model of the component to be replaced and send it to decentralized production centers equipped with 3D printers. This approach can enhance by far the supply chain management for automotive spare parts

Production Capacity Pooling in Additive Manufacturing, Possibilities and Challenges

Part 7: Operations Planning, Scheduling and ControlInternational audienceIndustries such as aviation tend to hold large amounts of capital tied to spare parts inventories to insure a high availability [1]. One effective approach to increase the efficiency in inventory management has been resource pooling [2]. However, the emergence of additive manufacturing (AM) enables the new paradigm of production capacity pooling, which varies from current ones. AM’s inherent characteristics may realize capacity sharing among distinct industries, alleviate the need for high safety stock levels and enable better customer service through the reduction of transshipments for spare parts. The advantages can be extended to the broader fulfillment reach of the firm in other geographical areas without expanding its existing production capacity or inventory (and other benefits from a distributed production setting). However, issues with inter-organizational agreements, testing and production reliability may slow down the pooling process while the required facilities are in place. This paper aims to extend the existing literature on implications of this growing phenomenon on inventory management practices. Study methodology is conceptual analysis