Metaphysics in K\uf6nigsberg prior to Kant (1703-1770)

The present contribute aims to reconstruct, using the methodology of intellectual history, the broad spectrum of metaphysical doctrines that Kant could know during the years of the formation of his philosophy. The first part deals with the teaching of metaphysics in K\uf6nigsberg from 1703 to 1770. The second part examines the main characteristics of the metaphysics in the various handbooks, which were taught at the Albertina, in order to have an exhaustive overview of all metaphysical positions

Benedetto Varchi on the Soul: Vernacular Aristotelianism between Reason and Faith

In this paper, I wish to present the first full-fledged investigation of Benedetto Varchi’s manuscript writings on psychology, which show the depth of his familiarity with philosophy and his originality as a thinker. In particular, I wish to show that Varchi was not an Averroist. Rather in the manuscript Varchi rejects Averroistic doctrines and seeks to reconcile Aristotelian psychology with the truth of religion. In so doing, Varchi appropriates Themistius’s interpretation of Aristotle through the filter of Marcantonio Zimara’s writings, which allows him to support the immortality and indivisibility of the human soul while safeguarding the doctrines of Christian faith

Metaphysics in Königsberg prior to Kant (1703-1770)

The present contribute aims to reconstruct, using the methodology of intellectual history, the broad spectrum of metaphysical doctrines that Kant could know during the years of the formation of his philosophy. The first part deals with the teaching of metaphysics in Königsberg from 1703 to 1770. The second part examines the main characteristics of the metaphysics in the various handbooks, which were taught at the Albertina, in order to have an exhaustive overview of all metaphysical positions

Aristotele e il problema della soggettivit\ue0

Gli storici della filosofia solitamente attribuiscono ai pensatori moderni l\u2019invenzioni di concetto \u201csoggetto\u201d, \u201coggetto\u201d e \u201csoggettivit\ue0\u201d e li concepiscono in direttamente in contrasto con la filosofia scolastica e aristotelica. Questo articolo suggerisce la presenza di una proto-teoria della soggettivit\ue0 in Aristotele. La teoria aristotelica della soggettivit\ue0 \ue8 fondata principalmente su quattro dottrine. In primo luogo, si pu\uf2 riscontrare nell\u2019epistemologia aristotelica la presenza di una \u201cprospettiva\u201d e di un \u201cpunto di vista\u201d. Il secondo aspetto significativo \ue8 il concetto di determinazione dell\u2019oggetto della conoscenza, che nella filosofia aristotelica \ue8 rappresentato dalla nozione di \u201cprosthesis\u201d. La terza dottrina si fonda sulla distinzione fra ci\uf2 che \ue8 pi\uf9 conoscibile per noi (gnorimoteron emin) e ci\uf2 che \ue8 pi\uf9 conoscibile per natura (gnorimoteron te physei). L\u2019ultima dottrina riguarda la seconda natura del soggetto e gli abiti della conoscenza acquisiti attraverso l\u2019esperienza, i quali spiegano perch\ue9 i soggetti abbiano conoscenze diverse degli stessi oggetti secondo le loro precedenti esperienze

The effects caused by the replacement of native riparian forest with Eucalyptus sp. on the benthic macro-invertebrate community.

The replacement of native riparian forests with exotic plants, especially Eucalyptus sp. can cause changes in ecological processes of small orders rivers. The leaves of Eucalyptus sp. have lower nutrients concentration, higher hardness and secondary metabolites which inhibit the decomposing micro-organisms and benthic macro-invertebrate colonization, which are the connection between the dead organic matter and the rest of the food chain. Thus the aim of the study was to test the following hypothesis: leaf decomposition rate will be lower in the substrate composed of Eucalyptus sp. leaves, when compared to the substrate composed of native tree species leaves; the benthic macro-invertebrates diversity will be lower in the substrate composed of Eucalyptus sp. leaves than the one composed of native tree species leaves. Sixty litter bags were used in the experiment, 30 of them were filled with 5 g of Eucalyptus sp leaves and the other 30 with a mixture of native trees leaves. From the results it was concluded that leaf decomposition rates were similar for both substrates, substrate composed of native trees leaves and substrate composed of Eucalyptus sp. leaves; the benthic macroinvertebrates diversity was lower in the substrate composed of Eucalyptus sp. leaves when compared to the substrate composed of native tree species leaves

Tracheostomy in the COVID-19 pandemic

Purpose: The role of tracheostomy in COVID-19-related ARDS is unknown. Nowadays, there is no clear indication regarding the timing of tracheostomy in these patients. Methods: We describe our synergic experience between ENT and ICU Departments at University Hospital of Modena underlining some controversial aspects that would be worth discussing tracheostomies in these patients. During the last 2 weeks, we performed 28 tracheostomies on patients with ARDS due to COVID-19 infection who were treated with IMV. Results: No differences between percutaneous and surgical tracheostomy in terms of timing and no case of team virus infection. Conclusion: In our experience, tracheostomy should be performed only in selected patients within 7- and 14-day orotracheal intubation

Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production

Background/Aims: Dietary polyphenols from green tea have been shown to possess cardio-protective activities in different experimental models of heart diseases and age-related ventricular dysfunction. The present study was aimed at evaluating whether long term in vivo administration of green tea extracts (GTE), can exert positive effects on the normal heart, with focus on the underlying mechanisms. Methods: The study population consisted of 20 male adult Wistar rats. Ten animals were given 40 mL/day tap water solution of GTE (concentration 0.3%) for 4 weeks (GTE group). The same volume of water was administered to the 10 remaining control rats (CTRL). Then, in vivo and ex vivo measurements of cardiac function were performed in the same animal, at the organ (hemodynamics) and cellular (cardiomyocyte mechanical properties and intracellular calcium dynamics) levels. On cardiomyocytes and myocardial tissue samples collected from the same in vivo studied animals, we evaluated: (1) the intracellular content of ATP, (2) the endogenous mitochondrial respiration, (3) the expression levels of the Sarcoplasmic Reticulum Ca2+-dependent ATPase 2a (SERCA2), the Phospholamban (PLB) and the phosphorylated form of PLB, the L-type Ca2+ channel, the Na+-Ca2+ exchanger, and the ryanodine receptor 2. Results: GTE cardiomyocytes exhibited a hyperdynamic contractility compared with CTRL (the rate of shortening and re-lengthening, the fraction of shortening, the amplitude of calcium transient, and the rate of cytosolic calcium removal were significantly increased). A faster isovolumic relaxation was also observed at the organ level. Consistent with functional data, we measured a significant increase in the intracellular ATP content supported by enhanced endogenous mitochondrial respiration in GTE cardiomyocytes, as well as higher values of the ratios phosphorylated-PLB/PLB and SERCA2/PLB. Conclusions: Long-term in vivo administration of GTE improves cell mechanical properties and intracellular calcium dynamics in normal cardiomyocytes, by increasing energy availability and removing the inhibitory effect of PLB on SERCA2

Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

AbstractThe supra-molecular assembly of the main respiratory chain enzymatic complexes in the form of “supercomplexes” has been proved by structural and functional experimental evidence. This evidence strongly contrasts the previously accepted Random Diffusion Model stating that the complexes are functionally connected by lateral diffusion of small redox molecules (i.e. Coenzyme Q and cytochrome c).This review critically examines the available evidence and provides an analysis of the functional consequences of the intermolecular association of the respiratory complexes pointing out the role of Coenzyme Q and of cytochrome c as channeled or as freely diffusing intermediates in the electron transfer activity of their partner enzymes

To what degree have the non-police public services adopted the National Intelligence Model? : what benefits could the National Intelligence Model deliver?

It is claimed that the National Intelligence Model (NIM) consolidated intelligence-led policing principles in investigative practice and decision making in British policing. Subsequently, encouraged by the Home Office, the NIM was adopted by a number of other public services with an investigative capability. However, that transfer took place without a sufficiently rigorous evaluation of the model’s value to the police service and without any meaningful analysis of its relevance to the investigative functions of other public sector agencies. This research examined the adoption of the NIM by three public sector bodies: The Department for Work and Pensions (DWP), The Identity and Passport Service (IPS) and the Driving Standards Agency (DSA). It drew on archival materials, associated literature and the analysis of semi-structured interviews with the personnel of these and associated agencies. Research respondents also assessed a simplified version of the NIM that was designed to remove many of the original model’s inconsistencies and ambiguities. The research identified that the reviewed public services are not compliant with the NIM minimum standards and that the model has not delivered any meaningful improvement in the consistency of process, investigative efficiency, improved partnership working, or in fraud reduction in those agencies. The NIM failed because of perceived complexity, the language of the model and supplementary guidance; its exclusive ‘fit’ with the police; and a suspicion by the agencies’ personnel that its adoption was intended as a performance management and governance tool. Moreover, the revised version of the NIM’s minimum standards did not improve comprehension or conformity, or resolve the model’s perceived police bias. It was concluded that the model is not fit for purpose for the agencies studied and that an alternative model that is more finely tuned to the needs of those agencies is required.EThOS - Electronic Theses Online ServiceGBUnited Kingdo