Gli studi medievistici di Cornelio Desimoni, un 'pioniere' della storia del territorio

ITALIANO: L’articolo consiste in una rassegna critica dell’opera di Cornelio Desimoni, storico molto versatile, dedicata fra il 1859 e il 1896 al periodo medievale. Accanto a commenti puntuali e all’esegesi di singoli documenti, a recensioni di testi di vario argomento, alla compilazione dei ponderosi annali della propria cittadina natale (Gavi), Desimoni ha affrontato ripetutamente un tema importante di storia politico-territoriale, in cui hanno pesato le sue competenze nel campo del diritto, con risultati molto maturi per l’epoca: le marche e i loro sviluppi nell’Italia a partire dal secolo IX. / ENGLISH: This article is a critical survey of the work that Cornelio Desimoni, a very versatile historian, dedicated to the middle ages during the period between 1859 and 1896. Apart from proffering precise comments, analyses of single documents, reviews of texts on various subjects and compiling the ponderous annals of his birth town (Gavi), Desimoni repeatedly tackled an important theme in political-territorial history: the marches and their development in Italy as from the 9th century. This latter accomplishment, which produced mature results for the time, was favoured by his competence in jurisprudence

Competitiveness and the Logistics Performance Index: The ANOVA method application for Africa, Asia, and the EU regions

Abstract This paper analyses the impact of strategic sub-components of the Global Competitiveness Index (GCI) on the Logistics Performance Index (LPI). As a hypothesis, it is assumed that there is a relationship between the LPI and selected factors in GCI, which were grouped into three clusters: infrastructure, human factor, and institutions. The purpose is to investigate which of those groups has the most significant impact on the LPI - an interactive comparative analysis tool created by the World Bank that addresses logistics issues in a broad context against world regions' development or countries' economies. For this purpose, the LPI was used as the dependent variable, while a linear regression model measured some GCI components' influence. The study was conducted for Africa, Asia, and the EU, employing the ANOVA method. The paper finds the three clusters are related to higher efficiency. While the new method shows these clusters are essential for improving the logistics performance index, an extensive range of factors might affect logistics sector performance in both geography and stage of development. In Europe, human factor is far more critical for progressively improving the LPI, while necessary infrastructure remains crucial in Asia. All three factors are central to Africa's logistics development

A rapid high-performance liquid chromatography-tandem mass spectrometry assay for unambiguous detection of different milk species employed in cheese manufacturing

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Diagnosis and treatment of headache probably attributed to cerebral venous sinus thrombosis

Cerebral venous sinus thrombosis (CVST) is a rare condition whose most common and sometimes only symptom is headache. Alas, diagnosis and treatment of CVST is often delayed or overlooked because of its high clinical variability. Using guidelines advices in detecting warning signs or symptoms of secondary headaches might ease the diagnosis of CVST.The article presents the case of a woman who is in treatment for chronic migraine and assessed for secondary headache in a multidisciplinary outpatient headache program. Alert symptoms like sudden worsening headache presentation, along with anamnestic cues, prompted neuroimaging that detected left transverse sinus thrombosis whose onset was difficult to date

Appropriateness of oral anticoagulants for long-term treatment of atrial fibrillation in older people: results of an evidence-based review and international consensus validation process (OAC-FORTA 2016)

Background: Age appropriateness of anticoagulants for stroke prevention in atrial fibrillation is uncertain. Objective: To review oral anticoagulants for the treatment of atrial fibrillation in older (age >65 years) people and to classify appropriate and inappropriate drugs based on efficacy, safety and tolerability using the Fit-fOR-The-Aged (FORTA) classification. Methods: We performed a structured comprehensive review of controlled clinical trials and summaries of individual product characteristics to assess study and total patient numbers, quality of major outcome data and data of geriatric relevance. The resulting evidence was discussed in a round table with an interdisciplinary panel of ten European experts. Decisions on age appropriateness were made using a Delphi process. Results: For the eight drugs included, 380 citations were identified. The primary outcome results were reported in 32 clinical trials with explicit and relevant data on older people. Though over 24,000 patients aged >75/80 years were studied for warfarin, data on geriatric syndromes were rare (two studies reporting on frailty/falls/mental status) and missing for all other compounds. Apixaban was rated FORTA-A (highly beneficial). Other non-vitamin K antagonist oral anticoagulants (including low/high-intensity dabigatran and high-intensity edoxaban) and warfarin were assigned to FORTA-B (beneficial). Phenprocoumon, acenocoumarol and fluindione were rated FORTA-C (questionable), mainly reflecting the absence of data. Conclusions: All non-vitamin K antagonist oral anticoagulants and warfarin were classified as beneficial or very beneficial in older persons (FORTA-A or -B), underlining the overall positive assessment of the risk/benefit ratio for these drugs. For other vitamin-K antagonists regionally used in Europe, the lack of evidence should challenge current practice