Understanding Student Computational Thinking with Computational Modeling

Recently, the National Research Council's framework for next generation science standards highlighted "computational thinking" as one of its "fundamental practices". 9th Grade students taking a physics course that employed the Modeling Instruction curriculum were taught to construct computational models of physical systems. Student computational thinking was assessed using a proctored programming assignment, written essay, and a series of think-aloud interviews, where the students produced and discussed a computational model of a baseball in motion via a high-level programming environment (VPython). Roughly a third of the students in the study were successful in completing the programming assignment. Student success on this assessment was tied to how students synthesized their knowledge of physics and computation. On the essay and interview assessments, students displayed unique views of the relationship between force and motion; those who spoke of this relationship in causal (rather than observational) terms tended to have more success in the programming exercise.Comment: preprint to submit to PERC proceedings 201

Immorality and Irrationality

Does immorality necessarily involve irrationality? The question is often taken to be among the deepest in moral philosophy. But apparently deep questions sometimes admit of deflationary answers. In this case we can make way for a deflationary answer by appealing to dualism about rationality, according to which there are two fundamentally distinct notions of rationality: structural rationality and substantive rationality. I have defended dualism elsewhere. Here, I’ll argue that it allows us to embrace a sensible – I will not say boring – moderate view about the relationship between immorality and irrationality: roughly, that immorality involves substantive irrationality, but not structural irrationality. I defend this moderate view, and argue that many of the arguments for less moderate views turn either on missing the distinction between substantive and structural rationality, or on misconstruing it

Potential Demand for Programs on Nuisance Wildlife Among Wildlife-Related Program Offerings to Urban/Suburban Organizations

Program planners of 114 organizations in the Roanoke Valley area of Virginia responded to the likelihood of their scheduling programs on wildlife-related topics. Among the topics offered was “Controlling Wildlife Pests and/or Their Damage.” Responses were organized by type of organization (civic club, neighborhood organization, educational/PTA organization, environmental/hobby organization, garden/plant club) and whether they were “highly likely” (HL), “somewhat likely” (SL), “not likely” (NL), or “not sure” (NS) they would schedule such a program. Results on likelihood of scheduling were as follows: 31 civic clubs (1 HL, 4 SL, 33NL, 4 NS); 26 neighborhood organizations (5 HL, 7 SL, 5 NL, 9 NS); 26 educational/PTA organizations (3HL, 7 SL, 14 NL, 2 NS); 10 environmental organizations (1 HL, 2 SL, 7 NL, 0 NS); and 21 garden clubs (2 HL, 6 SL, 11 NL, 2 NS). Overall, 114 respondents provided 12 HL, 26 SL, 59 NL, and 17 NS responses. Among the 114 respondents, only 8 rated the topic among their “top 3” most desired topics. In the overall survey, wildlife-related topics were not more acceptable than environmental program topics and, within the wildlife program topics, a program on “Controlling Wildlife Pests and/or Their Damage” was not likely to be scheduled by more than half the programs chairs. As only one-third of respondents indicated any likelihood of scheduling a program on “Controlling Wildlife Pests and/or Their Damage,” a challenge in developing proactive programs on wildlife pest management for urban/suburban club audiences seems very clear

Total chemical synthesis of a heterodimeric interchain Bis-Lactam-linked peptide: application to an analogue of human insulin-like peptide 3

Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule. Examples of these cystine mimics include dicarba, diselenide, thioether, triazole, and lactam bridges. Each has unique physicochemical properties that impact upon the resulting peptide conformation. Each also requires specific conditions for its formation via chemical peptide synthesis protocols. While the preparation of peptides containing two lactam bonds within a peptide is technically possible and reported by others, to date there has been no report of the chemical synthesis of a heterodimeric peptide linked by two lactam bonds. To examine the feasibility of such an assembly, judicious use of a complementary combination of amine and acid protecting groups together with nonfragment-based, total stepwise solid phase peptide synthesis led to the successful preparation of an analogue of the model peptide, insulin-like peptide 3 (INSL3), in which both of the interchain disulfide bonds were replaced with a lactam bond. An analogue containing a single disulfide-substituted interchain lactam bond was also prepared. Both INSL3 analogues retained significant cognate RXFP2 receptor binding affinity.John Karas, Fazel Shabanpoor, Mohammed Akhter Hossain, James Gardiner, Frances Separovic, John D. Wade and Denis B. Scanlo

Book Reviews

Book reviews by Julius Cohen, Edward F. Barrett, Roger P. Peters, Thomas M. Scanlon, and Clarence Manion

‘A Slow Build-Up of a History of Kindness’: Exploring the Potential of Community-Led Housing in Alleviating Loneliness

This article explores the potential of community-led housing (CLH) in combatting loneliness, and represents a mixed-methods research project carried out from just before the beginning of the pandemic, through 2020. Methods comprised a nationwide quantitative online survey of members of CLH groups (N = 221 respondents from England and Wales), followed by five case studies of communities representing a range of different CLH models. This qualitative element comprised participant observation, and semi-structured interviews at each group. The article also considers data from a smaller research project carried out by the same team in July 2020, that aimed to capture the experience of the pandemic for CLH groups, and comprising an online questionnaire followed by 18 semi-structured interviews. We conclude that members of CLH projects are measurably less lonely than those with comparable levels of social connection in wider society, and that such benefits are achieved through combinations of multiple different elements that include physical design, social design and through social processes. Notably, not all aspects of communities that contribute positively are a result of explicit intentionality, albeit the concept is considered key to at least one of the models

Investigation of lunar surface chemical contamination by LEM descent engine and associated equipment Final report

Lunar surface contamination from LEM rocket exhaust - methods of minimizing sample contaminatio

Reasons, Coherence, and Group Rationality

Philosophy and Phenomenological Research, EarlyView

TRH: Pathophysiologic and clinical implications

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases. The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown. The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course. But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive