A CASE REPORT ON AYURVEDIC MANAGEMENT OF VICHARCHIKA (ECZEMA)

Kushtarog is classified in 2 types i.e., Mahakushta and Kshudrakushta. Vicharchika is described under Kshudrakushta. Vicharchika is the type of Kshudrakushta often encountered by Ayurvedic dermatologists characterized with symptoms, namely, Kandu, Srava, Pidaka and Shyava varna. Vicharchika is often correlated to eczema based on the clinical presentations. The modern science has greatly advanced, particularly in dermatology but there is no specific medication for sure cure of eczema but symptomatic treatments like steroids are used, but they produce serious side effects like nephrotoxicity, osteoporosis, skin cancer etc. Whereas Ayurveda treats from the root of eczema by cleansing vitiated Dosha and balancing the Dosha and Dhatus without any side effects. A 27 years old male patient approached the OPD with the chief complaints of blackish discoloration, itching, flaking, cracking and bleeding over the anterior side of b/l legs. All the complaints were from 8 months. The patient was given completely Ayurvedic treatment with Panchnimbadi vati, Haridra khand, Gandhak rasayan vati and Sukshma triphala vati, Panchnimbadi churna lepa and Jalaukavcharan and the results were remarkably seen and there was significant improvement in the symptoms. Hence this study was taken to prove that Ayurvedic management has remarkable results in Vicharchika (eczema). Observation and results were drawn on the basis of assessment criteria. Discussion was done on the basis of entire observations during research. Conclusion was drawn on the basis of result

Management of Cardiopulmonary Complications of Cirrhosis

Advanced portal hypertension accompanying end-stage liver disease results in an altered milieu due to inadequate detoxification of blood from splanchnic circulation by the failing liver. The portosystemic shunts with hepatic dysfunction result in an increased absorption and impaired neutralisation of the gastrointestinal bacteria and endotoxins leads to altered homeostasis with multiorgan dysfunction. The important cardiopulmonary complications are cirrhotic cardiomyopathy, hepatopulmonary syndrome, portopulmonary hypertension, and right-sided hydrothorax

High redshift constraints on dark energy models and tension with the flat LambdaCDM model

So far large and different data sets revealed the accelerated expansion rate of the Universe, which is usually explained in terms of dark energy. The nature of dark energy is not yet known, and several models have been introduced: a non zero cosmological constant, a potential energy of some scalar field, effects related to the non homogeneous distribution of matter, or effects due to alternative theories of gravity. In [1, 2] a tension with the flat LambdaCDM model has been discovered using a high-redshift Hubble diagram of supernovae, quasars, and gamma-ray bursts. Here we use Union2 type Ia supernovae (SNIa) and Gamma Ray Bursts (GRB) Hubble diagram, and a set of direct measurements of the Hubble parameter to explore different dark energy models. We use the Chevallier-Polarski-Linder (CPL) parametrization of the dark energy equation of state (EOS), a minimally coupled quintessence scalar field, and, finally, we consider models with dark energy at early times (EDE). We perform a statistical analysis based on the Markov chain Monte Carlo (MCMC) method, and explore the probability distributions of the cosmological parameters for each of the competing models. We apply the Akaike Information Criterion (AIC) to compare these models: our analysis indicates that an evolving dark energy, described by a scalar field with exponential potential is favoured by observational data.Comment: 27 pages, 11 figures submitted to JCA

Synthesis of Cuprous Oxide (Cu2O) Nanoparticles – a Review

Cuprous Oxide (Cu2O) a semiconductor material oxide; with unique optoelectronic properties; gains significant importance for its synthesis in view of its various technological and industrial applications. A few liquid phase methods for the synthesis of Cu2O nanoparticles are reviewed on the basis of materials, methodology, synthesis conditions and key findings. A comparative study of these methods is also performed following criteria of repeatability, safety, cost, time span and simplicity. Contextual to the above mentioned criteria, three liquid phase synthesis techniques were shortlisted and actually experimented (as reported) to synthesize the Cu2O nanoparticles. This was done to investigate the effectiveness, repeatability and stability of the synthesized Cu2O product as a function of ageing time. The synthesized Cu2O using all these techniques are prone to be unstable and undergo the rapid phase change to CuO phase which was ascertained from the shift of absorbance peak in UV-VIS spectra. The results have highlighted the urgent need to develop a facile, economical, scalable and safe method to synthesize stable Cu2O nanoparticles at room temperature

Study of drug prescription pattern and adverse drug reaction monitoring in patients with hypertension and diabetes visiting outpatient department in a government tertiary care hospital in Maharashtra, India

Background: Drug utilization study is an important tool to study the clinical use of drugs and its impact on healthcare system. DUS in patients with HTN and DM is essential to observe the changing prescribing attitude of physicians with the aim to promote rational use of drugs and to minimize the adverse drug reactions.Methods: A cross sectional observational study was conducted on randomly selected patients attending medicine outpatient department in a tertiary care hospital. Drug prescription sheets of 600 patients were studied for 18 months from January 2016 to June 2017 and the prescribing pattern was analysed using the World Health Organization basic drug indicators.Results: Total 2029 drugs were prescribed to 600 patients that belonged to various classes. The average number of drugs prescribed per encounter was 3.4. Majority (61.5%) drugs were prescribed using generic names. Percentage encounters with the antibiotics and injections were 6.3 and 11.5 per cent respectively. 38% drugs were prescribed from the 20th edition of WHO Model List of Essential Medicines. PDD in the current study was found to be significantly less than WHO DDD in all drugs. All of the prescriptions in the present study conformed to WHO guidelines and majority of them with JNC VIII guidelines.Conclusions: The findings of this study are comparable to those of other studies. However, there is a scope of improvement in areas such as overdosing, prescribing more by generic names instead of brand names and from WHO Model List of Essential Medicines

EVOLUTION OF NANOTECH ASSISTED PCR DIAGNOSIS OF MYCOBACTERIUM TUBERCULOSIS AND ITS ASSESSMENT WITH CONVENTIONAL METHODS

Objective: This study was focused on assessment and performance of conventional and nanotech assisted methods for detection of Mycobacterium tuberculosis. Tuberculosis (TB) still leftovers one of the top ten causes of death worldwide, thus this study has undertaken the use of MNP for early detection of TB.Methods: A cross-sectional studies were conducted on clinical and radiological suspected TB patients in the department of microbiology at D. Y. Patil hospital Kolhapur. All samples received in the month of August 2016 to January 2017. Total One hundred twenty-sputum samples were processed for diagnosis of TB by ZN stain, culture on L. J. Medium and real-timePCR tests.Results: In our present study, 60.83% (73) patient male and 39.17 % (47) were female patient, showing a borderline male prevalence found in our study. Eighteen percent patients were found to be in the age group (21-30 y) are mostly affected for pulmonary tuberculosis. A significant difference was seen in the percentage of differentDNA extraction methods, the fig. being conventional chloroform-phenol 66.66%, the commercial kit 80%, magnetic bead 86.66% and MNPs method 99.66% found to be significant (P<0.0001**).Conclusion: In the present study the MNP-DNA extraction techniques with NALC followed by IS6110 target amplification were found superior for diagnosis of TB. The MNP assisted extraction method showed better results in terms of quantification and sensitivity of TB PCR diagnosis, evolving nanotech assisted innovative method

Study to evaluate the effect of Naradiya Laxmivilas Rasa and Goghruta Nasya in Vertigo (Bhrama)

Vertigo is a disturbance of sense of equilibrium and movements, where person feels that either his surroundings are going around him, or he himself is rotating. It varies from mild imbalance to severe vertigo accompanied by nausea and vomiting. In Ayurveda it can be compared to Bhrama which manifests as consequence of aggravation of Vata and Pitta Doshas along with Raja Guna resulting in spinning of head. An open randomized clinical trial was conducted to evaluate the effect of Naradiya Laxmi Vilas Rasa and Goghruta Nasya in vertigo w.s.r to Bhrama for duration of 2 months. 100 patients were selected and clinical evaluation was done by subjective and objective parameters. It was noted that there was significant relief in symptoms of Vertigo. So, it can be concluded that Naradiya Laxmi Vilas Rasa and Goghruta Nasya has significant effect on Vertigo (Bhrama)