(2E)-3-(4-Chloro­phen­yl)-1-(4-hy­droxy­phen­yl)prop-2-en-1-one

In the title compound, C15H11ClO2, the dihedral angle between the mean planes of the chloro­benzene and hy­droxy­benzene rings is 6.5 (6)°. The mean plane of the prop-2-en-1-one group makes an angle of 18.0 (1)° with the hy­droxy­phenyl ring and 11.5 (1)° with the chloro­phenyl ring. The crystal packing is stabilized by inter­molecular O—H⋯O hydrogen bonds, weak C—H⋯O, C—H⋯π and π–π stacking inter­actions [centroid–centroid distances = 3.7771 (7) and 3.6917 (7) Å]

Antistress and antimicrobial studies of biphenyl chalcone derivatives

This work reports the synthesis, characterization of new (2E)-1-(biphenyl-4-yl)-3-aryl)-prop-2-en-1-one derivatives (C1-C10). The chalcone derivatives were evaluated for in vitro antibacterial, antifungal, antioxidant activities. The compounds exhibited moderate to good antimicrobial activity at MIC 10-40 μg/mL. The compounds were docked at the active site of the methionyl-tRNA synthetase (metRS) (PDB ID: 1A8H) to predict their putative interactions. The compounds further screened for antioxidant property, amid C5, C7 and C8 exhibited good DPPH radical scavenging activity. Compound C5 was selected for antistress studies against gamma radiation induced oxidative stress markers in E .coli K 12. The C5 pretreatment and irradiated bacteria sample showed modulatory action of stress enzymes SOD and CAT to near basal level and significant demulating effect on the level of TBARS.Keywords: Biphenyl chalcone derivatives, radioprotection, antioxidant activity, antimicrobial activity, molecular dockin

Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3-dipolar cycloaddition method. The reaction proceeds through the formation of azomethine ylides generated in situ by the decarboxylative condensation of isatin and amino acids with dipolarophile chalcones. These compounds are active against Staphylococcus aureus, Escherichia coli, Aspergillus niger and Aspergillus flavus, supporting the in silico screening. In addition, their antitubercular activity was assessed using the MABA method. The compounds 3â²-[(4-fluorophenyl)carbonyl]-4â²-phenylspiro[indole-3,2â²-pyrrolidin]-2(1H)-one 3a, 4â²-(4-bromophenyl)-3â²-[(4-fluorophenyl)carbonyl]-5â²-(hydroxymethyl) spiro[indole-3,2â²-pyrrolidin]-2(1H)-one 3e and 4â²-(4-chlorophenyl)-3â²-[(4-fluorophenyl)carbonyl]-5â²-(2-methylpropyl)spiro[indole-3,2â²-pyrrolidin]-2(1H)-one 3g are potent molecules with MIC of 0.8 μg/mL. In the DPPH radical scavenging assay, compounds 4â²-(4-chlorophenyl)-3â²-[(4-fluorophenyl)carbonyl]spiro[indole-3,2â²-pyrrolidin]-2(1H)-one 3b, 4â²-(4-chlorophenyl)-3â²-[(4-fluorophenyl)carbonyl]-5â²-(hydroxymethyl)spiro[indole-3,2â²-pyrrolidin]-2(1H)-one 3d and 4â²-(4-bromophenyl)-3â²-[(4-fluorophenyl)carbonyl]-5â²-(hydroxymethyl)spiro[indole-3,2â²-pyrrolidin]-2(1H)-one 3e exhibited significant radical scavenging capacity. Keywords: Chalcone, Spiro-oxindole, Azomethine ylide, Antimicrobial activity, Molecular dockin