Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia

© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined. Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen concentrations the NO efflux is reinforced when band 3 is phosphorylated (p < 0.001). Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). However, the mechanisms by which fibrinogen signalling modulates erythrocyte function remain to be clarified and are currently under study. These conditions may be considered an approach to be followed in blood storage for transfusions.This study was supported by grants from the FCT - Fundação para a Ciência e a Tecnologia (project reference PTDC/SAU-OSM/73449/2006

Diffusion-limited deposition of dipolar particles

Deposits of dipolar particles are investigated by means of extensive Monte Carlo simulations. We found that the effect of the interactions is described by an initial, non-universal, scaling regime characterized by orientationally ordered deposits. In the dipolar regime, the order and geometry of the clusters depend on the strength of the interactions and the magnetic properties are tunable by controlling the growth conditions. At later stages, the growth is dominated by thermal effects and the diffusion-limited universal regime obtains, at finite temperatures. At low temperatures the crossover size increases exponentially as T decreases and at T=0 only the dipolar regime is observed.Comment: 5 pages, 4 figure

Constraining the evolution of the CMB temperature with SZ measurements from Planck data

The CMB temperature-redshift relation, T_CMB(z)=T_0(1+z), is a key prediction of the standard cosmology, but is violated in many non standard models. Constraining possible deviations to this law is an effective way to test the LambdaCDM paradigm and to search for hints of new physics. We have determined T_CMB(z), with a precision up to 3%, for a subsample (104 clusters) of the Planck SZ cluster catalog, at redshift in the range 0.01-- 0.94, using measurements of the spectrum of the Sunyaev Zel'dovich effect obtained from Planck temperature maps at frequencies from 70 to 353 GHz. The method adopted to provide individual determinations of T_CMB(z) at cluster redshift relies on the use of SZ intensity change, Delta I_SZ(nu), at different frequencies, and on a Monte-Carlo Markov Chain approach. By applying this method to the sample of 104 clusters, we limit possible deviations of the form T_CMB(z)=T_0(1+z)^(1-beta) to be beta= 0.022 +/- 0.018, at 1 sigma uncertainty, consistent with the prediction of the standard model. Combining these measurements with previously published results we get beta=0.016+/-0.012.Comment: submitted to JCAP, 21 pages, 8 figure

Características agronômicas das bananeiras `Maravilha` e `Prata Anã` sob coberturas vegetais no sistema orgânico em solo de Tabuleiro Costeiro.

O cultivo de bananeira no sistema orgânico tem se mostrado promissor em função de consumidores cada vez mais exigentes por produtos naturais livres de agroquímicos. A prática da adubação verde tem sido recomendada por proporcionar benefícios significativos

On the Uq[sl(2)]{\cal{U}}_{q}[sl(2)] Temperley-Lieb reflection matrices

This work concerns the boundary integrability of the spin-s ${\cal{U}}_{q}[sl(2)]$ Temperley-Lieb model. A systematic computation method is used to constructed the solutions of the boundary Yang-Baxter equations. For $s$ half-integer, a general $2s(s+1)+3/2$ free parameter solution is presented. It turns that for $s$ integer, the general solution has $2s(s+1)+1$ free parameters. Moreover, some particular solutions are discussed.Comment: LaTex 17 page