CONSTRUÇÃO DE MODELO TEÓRICO PARA AS SPIN-OFFS DA UNIVERSIDADE FEDERAL DE SANTA CATARINA - UFSC

O objetivo deste estudo é apresentar um modelo teórico para criação e desenvolvimento de spin-offs para a Universidade Federal de Santa Catarina - UFSC. De modo específico, pretende-se pesquisar modelos de gestão spin-offs universitárias em âmbito nacional e internacional; estruturar modelo teórico de spin-offs para a UFSC; pesquisar o estado da arte das teorias de governança, empreendedorismo e inovação no tocante às spin-offs, e deste modo, integrar e ajudar a formar a tríplice hélice do sistema de inovação catarinense. O ambiente físico de suporte para o desenvolvimento do estudo será o NOVUS – Ambiente de Desenvolvimento de Empreendimentos Inovadores, que foi criado em Fevereiro de 2017 e atualmente representa a incubadora da UFSC, tendo como objetivo apoiar o desenvolvimento de novos negócios criados a partir de projetos e ideias de alunos, professores e servidores técnicos-administrativos da UFSC.. Por fim, com os resultados da pesquisa, pretende-se promover uma integração entre as spin-offs da UFSC com os centros de inovação de Santa Catarina, de modo a permitir a troca de experiências de diferentes stakeholders de todo o sistema de inovação catarinense

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Construção de modelo teórico para as spin-offs da UFSC

Seminário de Iniciação Científica e Tecnológica Universidade Federal de Santa CatarinaO objetivo do projeto é estimular a criação e o desenvolvimento de spin-offs na Universidade Federal de Santa Catarina. Para isto, serão adotados critérios de governança, capacidade de inovação e cidade criativa. A governança será adotada considerando aspecto relacionados à estrutura universitária; mecanismos de crescimento; tecnologia, inovação e networking; sustentabilidade; e oportunidades de relacionamento nacional e internacional. A Capacidade de Inovação aplicada a partir de estímulos à inovação; inovatividade; desenvolvimento tecnológico; mecanismos de criação; e oportunidades de negócios nacionais e internacionais. Referente a cidade/universidade criativa serão utilizados fundamentos voltados ao ambiente inovadora; parcerias; geração de oportunidades; formação de redes; networking; e capacidade de formação de recursos humanos. Todas essas categorias buscam contribuir para a qualificação de gestores universitários e de empreendedores de spin-offs. Para isto, serão utilizados recursos financeiros para o desenvolvido de um sistema informacional que destaque as características das spin-offs da UFSC e que possa auxiliar na busca de oportunidades junto a stakeholders da comunidade universitária, assim como do sistema de inovação catarinense, fomentando a criação e o desenvolvimento das spin-offs universitárias. O ambiente físico de suporte para o desenvolvimento do projeto será o NOVUS – AMBIENTE DE DESENVOLVIMEN-TO DE EMPREENDIMENTOS INOVADORES (novus.ufsc.br), que foi criado em Fevereiro de 2017 e atualmente representa a incubadora da UFSC, tendo como objetivo apoiar o desenvolvimento de novos negócios criados a partir de projetos e ideias de alunos, professores e servidores técnicos-administrativos da UFSC. O Novus está localizado no Sapiens Parque, no andar ático do Prédio do Inpetro, e atualmente necessidade de alguns investimentos financeiros para que possa contribuir ainda mais para o sistema de inovação catarinense. Por fim, com os resultados da pesquisa pretende-se também promover uma integração entre as spin-offs da UFSC com os centros de inovação de Santa Catarina, de modo a permitir a troca de experiências de diferentes stakeholders de todo o sistema de inovação catarinense

Social Mobility and Mental Disorders at 30 Years of Age in Participants of the 1982 Cohort, Pelotas, Rio Grande Do Sul - RS.

This study aimed to evaluate the relationship between mental disorders at 30 years of age and social mobility by formally testing three hypotheses: Risk Accumulation; Critical Period; and Social Mobility. The study was performed using data from the 30-year follow-up of the Pelotas Birth Cohort Study, conducted in 1982, and data from previous follow-ups. The tool used to evaluate mental health was the Self Report Questionnaire (SRQ-20). For the statistical analysis, the chi-square test with the Yates correction was used to estimate the prevalence of mental disorder, and the Poisson regression with robust variance was used to formally test the hypotheses according to the Risk Accumulation, Critical Period and Social Mobility Models. The analyses were stratified by gender. The prevalence of Common Mental Disorders (CMDs) was 24.3% (95% CI 22.9-25.7) when the whole sample was considered. The highest prevalence, 27.1% (95% CI 25.1-29.2), was found in women, and the difference between genders was significant (p < 0.001). CMDs were more frequent in participants who remained "poor" in the three follow-ups. In both men and women, the best fit was obtained with the Risk Accumulation Model, with p = 0.6348 and p = 0.2105, respectively. The results indicate the need to rethink public income maintenance policies. Finally, we suggest further studies to investigate the role of different public policies in decreasing the prevalence of mental disorders and thus contribute proposals of new policies that may contribute to the prevention of these disorders

Prevalence of CMD in men and women, Pelotas, 2012.

<p>Prevalence of CMD in men and women, Pelotas, 2012.</p

Prevalence of CMD according to Social Mobility, Pelotas, 1982/2004/2012.

<p>0 = Poor 1 = Non-Poor</p><p>Prevalence of CMD according to Social Mobility, Pelotas, 1982/2004/2012.</p

Results of saturated and restricted tests according to the different hypotheses tested, Pelotas 1982/2004/2012.

<p>* Chi-square test</p><p>Results of saturated and restricted tests according to the different hypotheses tested, Pelotas 1982/2004/2012.</p

Acute brain inflammation and oxidative damage are related to long-term cognitive deficits and markers of neurodegeneration in sepsis-survivor rats

Survivors from sepsis present long-term cognitive deficits and some of these alterations resemble the pathophysiological mechanisms of neurodegenerative diseases. For this reason, we analyzed beta-amyloid peptide (Aβ) and synaptophysin levels in the brain of rats that survived from sepsis and their relation to cognitive dysfunction and to acute brain inflammation. Sepsis was induced in rats by cecal ligation and puncture, and 30 days after surgery, the hippocampus and prefrontal cortex were isolated just after cognitive evaluation by the inhibitory avoidance test. The immunocontent of Aβ and synaptophysin were analyzed by Western blot analysis. Aβ increased and synaptophysin decreased in septic animals both in the hippocampus and prefrontal cortex concurrent with the presence of cognitive deficits. Prefrontal levels of synaptophysin correlated to the performance in the inhibitory avoidance. Two different treatments known to decrease brain inflammation and oxidative stress when administered at the acute phase of sepsis decreased Aβ levels both in the prefrontal cortex and hippocampus, increased synaptophysin levels only in the prefrontal cortex, and improved cognitive deficit in sepsis-survivor animals. In conclusion, we demonstrated that brain from sepsis-survivor animals presented an increase in Aβ content and a decrease in synaptophysin levels and cognitive impairment. These alterations can be prevented by treatments aimed to decrease acute brain inflammation and oxidative stress