Weddellian marine/coastal vertebrates diversity from a basal horizon (Ypresian, Eocene) of the <i>Cucullaea</i> I Allomember, La Meseta formation, Seymour (Marambio) Island, Antarctica

La Formación La Meseta aflora en la Isla Seymour/Marambio, Mar de Weddell, noreste de la Península Antártica y contiene una de las asociaciones de vertebrados costeros/marinos de edad Eoceno temprano (Ypresiano) más diversa que se conoce a nivel mundial. Esta unidad está compuesta por areniscas marinas pobremente consolidadas las cuales fueron depositadas en ambientes costeros, deltaicos y/o estuarinos. Esta incluye invertebrados y vertebrados marinos así como plantas y vertebrados terrestres. El horizonte basal (el banco de Cucullaea, Telm 4) del Alomiembro Cucullaea I es lateralmente extensor y altamente fosilífero. Los restos de peces del banco de Cucullaea (Ypresiano) incluyen 35 especies con 26 familias y representa una de las más abundantes y diversas fauna de vertebrados fósiles registradas en latitudes altas. La distribución estratigráfica y las relaciones filogenéticas de los pingüinos fósiles (Sphenisciformes) son consistentes con la primera radiación de este grupo en el Eoceno temprano. El primer incuestionable Archaeoceti de Antártida es registrado en esta unidad y es referido un nuevo taxón.The La Meseta Formation crops out in Seymour/Marambio Island, Weddell Sea, northeast of the Antarctic Peninsula and contains one of the world's most diverse assemblages of Weddellian marine/coastal vertebrates of Early Eocene (Ypresian) age. The La Meseta Formation is composed of poorly consolidated, marine sandstones and siltstones which were deposited in a coastal, deltaic and/or estuarine environment. It includes marine invertebrates and vertebrates as well as terrestrial vertebrates and plants. The highly fossiliferous basal horizon (Cucullaea shell bed, Telm 4 of Sadler 1988) of the Cucullaea I Allomember is a laterally extensive shell bed with sandy matrix. The fish remains, including 35 species from 26 families, of the Ypresian Cucullaea bed represent one of the most abundant and diverse fossil vertebrate faunas yet recorded in southern latitudes. Stratigraphic distribution and phylogenetic relationships of the Weddellian sphenisciforms are consistent with a first radiation of this group in the Early Eocene. The first inquestionable archaeocete from Antarctica is recorded in this unit and is referred to a new taxon.Facultad de Ciencias Naturales y Muse

Eocene ungulate mammals from West Antarctica: implications from their fossil record and a new species

Here we describe a new terrestrial mammal from the Eocene of Seymour Island (Isla Marambio) represented by a lower left third molar and assigned to a new species of Sparnotheriodontidae, an ungulate family with a broad palaeobiogeographical distribution in South America. The specimen was found in the Cucullaea I allomember of the La Meseta Formation, in a new mammalian locality (IAA 2/16). Notiolofos regueroi sp. nov. shares a brachyodont, lophoselenodont and bicrescentic molar pattern with N. arquinotiensis, recorded for a stratigraphic sequence of 17.5 Ma in Antarctica. The criteria for the species differentiation are the absence of mesial and labial cingulids, the larger paraconid, the wider talonid basin, the accentuated distal projection of the hypoconulid, the centroconid development and the smaller size. Together with the astrapotherian Antarctodon sobrali, they represent the medium to large terrestrial mammals of the early Eocene Antarctic landscape that was mostly dominated by closed forests of Nothofagus. Dental wear facets and differences in their body mass are inferred and discussed as possible evidence of niche differentiation. Additionally, the presence of land mammals with Patagonian affinities in the Eocene of Antarctica reinforces the Cretaceous-Palaeocene presence of the Weddellian Isthmus, a functional land corridor between Antarctica and South America.Facultad de Ciencias Naturales y Muse

Eocene ungulate mammals from West Antarctica: implications from their fossil record and a new species

Here we describe a new terrestrial mammal from the Eocene of Seymour Island (Isla Marambio) represented by a lower left third molar and assigned to a new species of Sparnotheriodontidae, an ungulate family with a broad palaeobiogeographical distribution in South America. The specimen was found in the Cucullaea I allomember of the La Meseta Formation, in a new mammalian locality (IAA 2/16). Notiolofos regueroi sp. nov. shares a brachyodont, lophoselenodont and bicrescentic molar pattern with N. arquinotiensis, recorded for a stratigraphic sequence of 17.5 Ma in Antarctica. The criteria for the species differentiation are the absence of mesial and labial cingulids, the larger paraconid, the wider talonid basin, the accentuated distal projection of the hypoconulid, the centroconid development and the smaller size. Together with the astrapotherian Antarctodon sobrali, they represent the medium to large terrestrial mammals of the early Eocene Antarctic landscape that was mostly dominated by closed forests of Nothofagus. Dental wear facets and differences in their body mass are inferred and discussed as possible evidence of niche differentiation. Additionally, the presence of land mammals with Patagonian affinities in the Eocene of Antarctica reinforces the Cretaceous-Palaeocene presence of the Weddellian Isthmus, a functional land corridor between Antarctica and South America.Facultad de Ciencias Naturales y Muse

Misinformation, Trust, and Use of Ivermectin and Hydroxychloroquine for COVID-19

Importance The COVID-19 pandemic has been notable for the widespread dissemination of misinformation regarding the virus and appropriate treatment. Objective To quantify the prevalence of non–evidence-based treatment for COVID-19 in the US and the association between such treatment and endorsement of misinformation as well as lack of trust in physicians and scientists. Design, Setting, and Participants This single-wave, population-based, nonprobability internet survey study was conducted between December 22, 2022, and January 16, 2023, in US residents 18 years or older who reported prior COVID-19 infection. Main Outcome and Measure Self-reported use of ivermectin or hydroxychloroquine, endorsing false statements related to COVID-19 vaccination, self-reported trust in various institutions, conspiratorial thinking measured by the American Conspiracy Thinking Scale, and news sources. Results A total of 13 438 individuals (mean [SD] age, 42.7 [16.1] years; 9150 [68.1%] female and 4288 [31.9%] male) who reported prior COVID-19 infection were included in this study. In this cohort, 799 (5.9%) reported prior use of hydroxychloroquine (527 [3.9%]) or ivermectin (440 [3.3%]). In regression models including sociodemographic features as well as political affiliation, those who endorsed at least 1 item of COVID-19 vaccine misinformation were more likely to receive non–evidence-based medication (adjusted odds ratio [OR], 2.86; 95% CI, 2.28-3.58). Those reporting trust in physicians and hospitals (adjusted OR, 0.74; 95% CI, 0.56-0.98) and in scientists (adjusted OR, 0.63; 95% CI, 0.51-0.79) were less likely to receive non–evidence-based medication. Respondents reporting trust in social media (adjusted OR, 2.39; 95% CI, 2.00-2.87) and in Donald Trump (adjusted OR, 2.97; 95% CI, 2.34-3.78) were more likely to have taken non–evidence-based medication. Individuals with greater scores on the American Conspiracy Thinking Scale were more likely to have received non–evidence-based medications (unadjusted OR, 1.09; 95% CI, 1.06-1.11; adjusted OR, 1.10; 95% CI, 1.07-1.13). Conclusions and Relevance In this survey study of US adults, endorsement of misinformation about the COVID-19 pandemic, lack of trust in physicians or scientists, conspiracy-mindedness, and the nature of news sources were associated with receiving non–evidence-based treatment for COVID-19. These results suggest that the potential harms of misinformation may extend to the use of ineffective and potentially toxic treatments in addition to avoidance of health-promoting behaviors

Relationship between solidification microstructure and hot cracking susceptibility for continuous casting of low-carbon and high-strength low-alloyed steels: A phase-field study

© The Minerals, Metals & Materials Society and ASM International 2013Hot cracking is one of the major defects in continuous casting of steels, frequently limiting the productivity. To understand the factors leading to this defect, microstructure formation is simulated for a low-carbon and two high-strength low-alloyed steels. 2D simulation of the initial stage of solidification is performed in a moving slice of the slab using proprietary multiphase-field software and taking into account all elements which are expected to have a relevant effect on the mechanical properties and structure formation during solidification. To account for the correct thermodynamic and kinetic properties of the multicomponent alloy grades, the simulation software is online coupled to commercial thermodynamic and mobility databases. A moving-frame boundary condition allows traveling through the entire solidification history starting from the slab surface, and tracking the morphology changes during growth of the shell. From the simulation results, significant microstructure differences between the steel grades are quantitatively evaluated and correlated with their hot cracking behavior according to the Rappaz-Drezet-Gremaud (RDG) hot cracking criterion. The possible role of the microalloying elements in hot cracking, in particular of traces of Ti, is analyzed. With the assumption that TiN precipitates trigger coalescence of the primary dendrites, quantitative evaluation of the critical strain rates leads to a full agreement with the observed hot cracking behavior. © 2013 The Minerals, Metals & Materials Society and ASM International

Community Mobility and Depressive Symptoms During the COVID-19 Pandemic in the United States

Importance Marked elevation in levels of depressive symptoms compared with historical norms have been described during the COVID-19 pandemic, and understanding the extent to which these are associated with diminished in-person social interaction could inform public health planning for future pandemics or other disasters. Objective To describe the association between living in a US county with diminished mobility during the COVID-19 pandemic and self-reported depressive symptoms, while accounting for potential local and state-level confounding factors. Design, Setting, and Participants This survey study used 18 waves of a nonprobability internet survey conducted in the United States between May 2020 and April 2022. Participants included respondents who were 18 years and older and lived in 1 of the 50 US states or Washington DC. Main Outcome and Measure Depressive symptoms measured by the Patient Health Questionnaire-9 (PHQ-9); county-level community mobility estimates from mobile apps; COVID-19 policies at the US state level from the Oxford stringency index. Results The 192 271 survey respondents had a mean (SD) of age 43.1 (16.5) years, and 768 (0.4%) were American Indian or Alaska Native individuals, 11 448 (6.0%) were Asian individuals, 20 277 (10.5%) were Black individuals, 15 036 (7.8%) were Hispanic individuals, 1975 (1.0%) were Pacific Islander individuals, 138 702 (72.1%) were White individuals, and 4065 (2.1%) were individuals of another race. Additionally, 126 381 respondents (65.7%) identified as female and 65 890 (34.3%) as male. Mean (SD) depression severity by PHQ-9 was 7.2 (6.8). In a mixed-effects linear regression model, the mean county-level proportion of individuals not leaving home was associated with a greater level of depression symptoms (β, 2.58; 95% CI, 1.57-3.58) after adjustment for individual sociodemographic features. Results were similar after the inclusion in regression models of local COVID-19 activity, weather, and county-level economic features, and persisted after widespread availability of COVID-19 vaccination. They were attenuated by the inclusion of state-level pandemic restrictions. Two restrictions, mandatory mask-wearing in public (β, 0.23; 95% CI, 0.15-0.30) and policies cancelling public events (β, 0.37; 95% CI, 0.22-0.51), demonstrated modest independent associations with depressive symptom severity. Conclusions and Relevance In this study, depressive symptoms were greater in locales and times with diminished community mobility. Strategies to understand the potential public health consequences of pandemic responses are needed

Design of Dressed Crab Cavities for the HL-LHC Upgrade

The HL-LHC upgrade relies on a set of RF crab cavities for reaching its goals. Two parallel concepts, the Double Quarter Wave (DQW) and the RF Dipole (RFD), are going through a comprehensive design process along with preparation of fabrication in view of extensive tests with beam in SPS. High Order Modes (HOM) couplers are critical in providing damping in RF cavities for operation in accelerators. HOM prototyping and fabrication have recently started at CERN. In this paper, an overview of the final geometry is provided along with an insight in the mechanical and thermal analyses performed to validate the design of this critical component. Emphasis is also given to material selection, prototyping, initial fabrication and test campaigns that are aimed at fulfilling the highly demanding tolerances of the couplers