FROM WORLD 3 TO THE SOCIAL ASSESSMENT OF TECHNOLOGY

The monodirectional model of development of technology, from science to markai, reduces the role of society regarding technology to a passive element. The society is in practed by technology. The impacts could be good or not. We can identify and analyse (in advance) these impacts through the Technology Assessment methodology. Thus Technology Assessment is the same that Impacts Technology Assessment. However, we could interpet the development of technology according to multidirectional models (for example, evolutionary multidirectional models). In these models the society could play an active role. Society is not only the impacted target for technological development. Society is also the factor shaping technology. The second interpretation of technological development makes possible to propose and perform a methodology of Technology Assessment where relevant social groups (involved in or affected by the technology at issue) must be identified and their social behaviour has to be analyzed in situations of conflict (between groups) in order to detect the different technological options and their potential different impacts. It is the so-called Social (Strategic or Constructive) Technology Assessment

Modular Planar Antenna at X-band for satellite communications

An antenna which has been conceived as a portable system for satellite communications based on the recommendations ITU-R S.580-6 [1] and ITU-R S.465-5 [2] for small antennas, i.e., with a diameter lower than 50 wavelengths, is introduced. It is a planar and a compact structure with a size of 40×40×2 cm. The antenna is formed by an array of 256 printed elements covering a large bandwidth (14.7%) at X-Band. The specification includes transmission (Tx) and reception (Rx) bands simultaneously. The printed antenna has a radiation pattern with a 3dB beamwidth of 5°, over a 31dBi gain, and a dual and an interchangeable circular polarizatio

Portable low profile antenna at X-band

An antenna which has been conceived as a portable system for satellite communications based on the recommendations ITU-R S.580-6 and ITU-R S.465-5 for small antennas, i.e., with a diameter lower than 50 wavelengths, is introduced. It is a planar and a compact structure with a size of 40×40×2 cm. The antenna is formed by an array of 256 printed elements covering a large bandwidth (14.7%) at X-Band with a VSWR of 1.4:1. The specification includes transmission (Tx) and reception (Rx) bands simultaneously. The printed antenna has a radiation pattern with a 3dB beamwidth of 5°, over a 31dBi gain, and a dual and an interchangeable circular polarization

Ao redor do invisível: o tempo em suspensão no processo criativo de Cláudia França

Nesse artigo nos aproximamos da reflexão de que uma obra colocada ao público, se vista pelos seus bastidores, por aquilo que a contém e que a gerou, pode fornecer dados inestimáveis para a História da Arte e para os estudos dos processos criativos. Assim, este artigo busca desenvolver um estudo reflexivo sobre o tempo como disparador e como matéria no processo criativo de Cláudia França, na exposição “Trabalho do Chão”, de 2019, quando recria um ambiente doméstico de forma simbólica, buscando gerar reflexões sobre as noções de paisagem e arquitetura e as relações humanas. Partimos da hipótese de que a artista corta o espaço e o reconstrói em uma espécie de tempo como instante, fragmento de uma duração interrompida. Estudamos os cadernos da artista e seus demais documentos de processo, para compreender algumas das escolhas que levaram ao formato final da obra apresentada ao público. Buscamos revelar como procedimentos tradicionais do desenho são incorporados em uma poética tridimensional que compartilha a intimidade da artista. Tratamos seu procedimento a partir de conceitos de criatividade e inovação que toma processos clássicos e os reelabora na construção de uma obra que questiona os limites do desenho e da escultura contemporâneos

Texto-Livro, Texto-Filme: Aparições de Macunaíma inspiradas na poética de Mário de Andrade

In 1928, writer Mario de Andrade presented to the conservative Brazilian society the pages of Macunaíma. Four decades later, film director Joaquim Pedro de Andrade, inspired on the book, brought Macunaíma to the film screens. Two creative appearances about the same character, in different languages, which have become symbols of artistic movements: “Modernismo” and “Cinema Novo”. This work aims to analyze the intersemiotic tensions created from the written signs that identify the hero Macunaíma, and its transposition to the audiovisual media, taking into account the limits of each medium and how social and political context influenced these artists.En 1928, el escritor Mario de Andrade presentó a la sociedad brasileña conservadora las páginas de Macunaíma. Cuatro décadas después, el director de cine Joaquim Pedro de Andrade llevó a la pantalla la película Macunaíma, basada en el libro. Dos apariciones creativas sobre un mismo personaje en diferentes lenguajes, que se han convertido en símbolos de los movimientos artísticos: el “Modernismo” y el “Cinema Novo”. Este trabajo se propone analizar las tensiones intersemioticas creadas a partir de signos escritos que identifican al héroe Macunaíma, y su transposición al medio audiovisual, teniendo en cuenta los límites de cada medio y las influencias del contexto sociopolítico.Em 1928, o escritor Mario de Andrade apresentava à conservadora sociedade brasileira as páginas de Macunaíma, um herói sem nenhum caráter. Quatro décadas depois, Joaquim Pedro de Andrade levava às telas o filme Macunaíma, inspirado no livro. Duas aparições criativas sobre o mesmo personagem em diferentes linguagens, que se tornaram símbolos de movimentos artísticos: o Modernismo e o Cinema Novo. Este trabalho propõe analisar as tensões intersemióticas criadas a partir de signos escritos que identificam o herói Macunaíma, e sua transposição para a mídia audiovisual, levando em conta os limites de cada suporte e as influências sócio-políticas de cada época

Mechanically interlocked molecules in metal–organic frameworks

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemical Society Reviews, copyright © Royal Society of Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.rsc.org/en/content/articlelanding/2022/CS/D2CS00167EMechanically interlocked molecules (MIMs) have great potential in the development of molecular machinery due to their intercomponent dynamics. The incorporation of these molecules in a condensed phase makes it possible to take advantage of the control of the motion of the components at the macroscopic level. Metal–organic frameworks (MOFs) are postulated as ideal supports for intertwined molecules. This review covers the chemistry of the mechanical bond incorporated into metal–organic frameworks from the seminal studies to the latest published advances. We first describe some fundamental concepts of MIMs and MOFs. Next, we summarize the advances in the incorporation of rotaxanes and catenanes inside MOF matrices. Finally, we conclude by showing the study of the rotaxane dynamics in MOFs and the operation of some stimuli-responsive MIMs within MOFs. In addition to emphasising some selected examples, we offer a critical opinion on the state of the art of this research field, remarking the key points on which the future of these systems should be focused

Prevalence of FLG loss-of-function mutations R501X, 2282del4, and R2447X in Spanish children with atopic dermatitis

Background/Objectives Atopic dermatitis (AD) is the most prevalent inflammatory skin disorder, and is often associated with a personal or family history of atopic disease. The presence of loss-of-function mutations in the filaggrin gene (FLG) is the main predisposing factor for AD FLG mutations show ethnic and geographical variations, even between European populations. We sought to determine the frequency of the 3 most common FLG null mutations in a population of Spanish children consisting of healthy controls and AD patients. We also investigated the association between these 3 FLG mutations and AD. Methods A total of 214 participants (111 AD patients and 103 healthy controls) were enrolled in this study. Genotyping for 3 FLG null mutations (R501X, 2282del4, and R2447X) was performed by conventional Sanger sequencing. Results The combined mutation frequency was 1.9% in the control group and 12.6% in the AD group. The most common FLG mutation in AD patients was R501X (9.9%), followed by R2447X (2.7%) and 2282del4 (1.8%). Conclusion These findings further our understanding of the prevalence of FLG null mutations in the Spanish population, and suggest that the frequency of FLG mutations in AD patients in Spain is slightly higher than that of other Mediterranean countries

Ivabradine-Stimulated Microvesicle Release Induces Cardiac Protection against Acute Myocardial Infarction.

Ivabradine can reduce heart rate through inhibition of the current I(f ) by still unexplored mechanisms. In a porcine model of ischemia reperfusion (IR), we found that treatment with 0.3 mg/kg Ivabradine increased plasma release of microvesicles (MVs) over Placebo, as detected by flow cytometry of plasma isolated from pigs 7 days after IR, in which a tenfold increase of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) containing (both high and low-glycosylated) MVs, was detected in response to Ivabradine. The source of MVs was investigated, finding a 37% decrease of CD31+ endothelial cell derived MVs, while CD41+ platelet MVs remained unchanged. By contrast, Ivabradine induced the release of HCN4+ (mostly cardiac) MVs. While no differences respect to EMMPRIN as a cargo component were found in endothelial and platelet derived MVs, Ivabradine induced a significant release of EMMPRIN+/HCN4+ MVs by day 7 after IR. To test the role of EMMPRIN+ cardiacMVs (EMCMV), H9c2 cellmonolayers were incubated for 24 h with 107 EMCMVs, reducing apoptosis, and increasing 2 times cell proliferation and 1.5 times cell migration. The in vivo contribution of Ivabradine-induced plasma MVs was also tested, in which 108 MVs isolated from the plasma of pigs treated with Ivabradine or Placebo 7 days after IR, were injected in pigs under IR, finding a significant cardiac protection by increasing left ventricle ejection fraction and a significant reduction of the necrotic area. In conclusion ivabradine induces cardiac protection by increasing at least the release of EMMPRIN containing cardiac microvesicles.post-print1810 K

Personalized Management of Fatigue in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Using a Smart Digital mHealth Solution: Protocol for a Participatory Design Approach

Fatigue; Myalgic encephalomyelitis/chronic fatigue syndrome; Personalized self-managementFatiga; Encefalomielitis miálgica/síndrome de fatiga crónica; Autogestión personalizadaFatiga; Encefalomielitis miàlgica/síndrome de fatiga crònica; Autogestió personalitzadaBackground: Fatigue is the most common symptom in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID, impacting patients’ quality of life; however, there is currently a lack of evidence-based context-aware tools for fatigue self-management in these populations. Objective: This study aimed to (1) address fatigue in ME/CFS and long COVID through the development of digital mobile health solutions for self-management, (2) predict perceived fatigue severity using real-time data, and (3) assess the feasibility and potential benefits of personalized digital mobile health solutions. Methods: The MyFatigue project adopts a patient-centered approach within the participatory health informatics domain. Patient representatives will be actively involved in decision-making processes. This study combines inductive and deductive research approaches, using qualitative studies to generate new knowledge and quantitative methods to test hypotheses regarding the relationship between factors like physical activity, sleep behaviors, and perceived fatigue in ME/CFS and long COVID. Co-design methods will be used to develop a personalized digital solution for fatigue self-management based on the generated knowledge. Finally, a pilot study will evaluate the feasibility, acceptance, and potential benefits of the digital health solution. Results: The MyFatigue project opened to enrollment in November 2023. Initial results are expected to be published by the end of 2024. Conclusions: This study protocol holds the potential to expand understanding, create personalized self-management approaches, engage stakeholders, and ultimately improve the well-being of individuals with ME/CFS and long COVID.This study received funding from the Spanish Ministry of Science and Innovation (Knowledge Generation Project Grant PID-2021-125528OB-I00), and it was cofunded by the 2020 European Union’s Research and Innovation Funding Program

ANTIMATTER, a PDP11 real-time audiovisualization project

[ES] El colectivo PDP11 es un grupo de artistas que provienen del punk, del rock, de la bossa nova, del cine experimental, del arte interactivo y del videoarte. En los inicios el colectivo centró su trabajo en las relaciones entre el sonido y la imagen. PDP11 construye su discurso visual al margen de lo tangible elevando el sonido al irracional firmamento de las matemáticas y desde allí, retoma impoluto a una nueva identidad, la dimensión de los colores. El sonido dejado al vaivén del momento toma su forma en ruidos, distorsiones, guitarras, sintetizadores, bajos, voces y silencios. Los proyectos se desarrollan de forma colectiva a partir de una idea modulada por las aportaciones personales durante su desarrollo. El proyecto Antimatter que se presenta está inspirado en el concepto físico de antimateria. El universo de las partículas y antipartículas, y sobre todo la transformación que se produce cuando colisionan fundamenta la estructura de este proyecto.[EN] The PDP11 collective is a group of artists that come from punk, rock, bossa nova, experimental cinema, interactive art and video art. In the beginning, the collective focused its work on the relationships between sound and image. PDP11 builds its visual discourse on the margin of the tangible by raising the sound to the irrational firmament of mathematics and from there, it untaintedly takes on a new identity, the dimension of colors. The sound left to the swing of the moment takes its form in noises, distortions, guitars, synthesizers, basses, voices and silences. The projects are developed collectively from an idea modulated by personal contributions during its development. The Antimatter project that we present is inspired by the physical concept of antimatter. The universe of the particles and antiparticles, and especially the transformation that occurs when they collide, bases the structure of this project.García Miragall, CM.; Martínez De Pisón Ramón, MJ.; Sanmartin Piquer, FJ. (2019). ANTIMATTER, un proyecto de audiovisualización en tiempo real de PDP11. En IV Congreso Internacional de investigación en artes visuales: ANIAV 2019 Imagen [N] visible. Editorial Universitat Politècnica de València. 300-305. https://doi.org/10.4995/ANIAV.2019.2019.9057OCS30030