Biografía de Luigi Salvatorelli

Historiador italiano, publicista, político durante el ascenso de Benito Mussolin

Carta dirigida al Sr. Basave

Historiador italiano, publicista, político durante el ascenso de Benito Mussolin

Sobre con 2 timbres

Historiador italiano, publicista, político durante el ascenso de Benito Mussolin

Fotografía Personal

Historiador italiano, publicista, político durante el ascenso de Benito Mussolin

The role of hypoxia and SRC tyrosine kinase in glioblastoma invasiveness and radioresistance

CERVOXY COLLInternational audienceAdvances in functional imaging are supporting neurosurgery and radiotherapy for glioblastoma, which still remains the most aggressive brain tumor with poor prognosis. The typical infiltration pattern of glioblastoma, which impedes a complete surgical resection, is coupled with a high rate of invasiveness and radioresistance, thus further limiting efficient therapy, leading to inevitable and fatal recurrences. Hypoxia is of crucial importance in gliomagenesis and, besides reducing radiotherapy efficacy, also induces cellular and molecular mediators that foster proliferation and invasion. In this review, we aimed at analyzing the biological mechanism of glioblastoma invasiveness and radioresistance in hypoxic niches of glioblastoma. We also discussed the link between hypoxia and radiation-induced radioresistance with activation of SRC proto-oncogene non-receptor tyrosine kinase, prospecting potential strategies to overcome the current limitation in glioblastoma treatment

Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model

Proton boron capture therapy (PBCT) in a preclinical glioblastoma model exhibits increased therapeutic effectiveness with an increased cell death and mitophagy, supporting its use as a scalable strategy to treat glioblastoma