Разработка распределенной системы концептуального проектирования сложных технических объектов

Small wetlands increasingly become important agricultural production niches in sub-Saharan Africa. Understanding the diversity of these households may help to develop guidelines for their future use. In this study a typology of households in small wetlands was developed using case studies of 275 farmers from Kenya and Tanzania. Based on a combination of production system attributes land resources, and production objectives, households were categorised into 12 farm types. Production resources, access to cropland on upland, access to market, and non-wetland related livelihood strategies differed between households and translated into different wetland use patterns. Farm types were linked to the prevailing wetland systems. The household typology captured various dimensions in values, attitudes, and goals of farmers and determined their influence on land use decisions. The wetland field: farm size ratio differed significantly between farm types. More than one-third of the households depended completely on cropland in the wetland. The variable nature of household dependence was reflected in diverse production orientations with different levels of land use intensity and subsequent pressure on wetlands. The heterogeneity induced agricultural practices among households and the complexity of the wetland system highlight the need for specific incentives to develop sustainable plans for wetland management

Evaluation and visualization of multiaxial stress and strain states under non-proportional loading

This paper presents a simple method of determining stresses and strains and a severity of loading history under non-proportional loadings with defining the rotation angles of the maximum principal stress and strain in a three dimensional stress and strain space. Based on the method, non-proportional stress and strain ranges are derived and applicability of the range to the life evaluation for low carbon steel under non-proportional random strain paths are discussed. The strain range taking account of intensity of loading path reducing life can be suitable parameter for multiaxial fatigue life evaluation under multiaxial non-proportional loading. This paper also shows a method of visually presenting the principal stress and strain that assists designers to understand the loading mode whether proportional or non-proportional under 3 dimensional (6 stress/strain components) multiaxial loading

Autoimmunity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66083/1/j.1365-4362.1981.tb00393.x.pd

Bounding λ2 for Kähler–Einstein metrics with large symmetry groups

We calculate an upper bound for the second non-zero eigenvalue of the scalar Laplacian, λ2, for toric-Kähler–Einstein metrics in terms of the polytope data. We also give a similar upper bound for Koiso–Sakane type Kähler–Einstein metrics. We provide some detailed examples in complex dimensions 1, 2 and 3

Intranasal administration of acetylcholinesterase inhibitors

This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing confirmed achievement of therapeutically relevant drug levels that matched or exceeded those for oral dosing, with a dramatic reduction in undesired emetic responses. Intranasal drug delivery is an effective option for the treatment of Alzheimer's disease and other central nervous system disorders

The HIV-1 Tat Protein is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7

The HIV-1 transactivator protein Tat is a critical regulator of HIV transcription primarily enabling efficient elongation of viral transcripts. Its interactions with RNA and various host factors are regulated by ordered, transient post-translational modifications. Here, we report a novel Tat modification, monomethylation at lysine 71 (K71). We found that Lys-71 monomethylation (K71me) is catalyzed by KMT7, a methyltransferase that also targets lysine 51 (K51) in Tat. Using mass spectrometry, in vitro enzymology, and modification-specific antibodies, we found that KMT7 monomethylates both Lys-71 and Lys-51 in Tat. K71me is important for full Tat transactivation, as KMT7 knockdown impaired the transcriptional activity of wild type (WT) Tat but not a Tat K71R mutant. These findings underscore the role of KMT7 as an important monomethyltransferase regulating HIV transcription through Tat

The attachments of the anteromedial and posterolateral fibre bundles of the anterior cruciate ligament: Part 1: tibial attachment.

Accepted versio