Stationary Proportional Hazard Processes via Complementary Power Function Distribution Processes

In the following, we introduce new proportional hazard (PH) processes, which are derived by a marginal transformation applied to complementary power function distribution (CPFD) processes. Also, we introduce two new Pareto processes, which are derived from the proportional hazard family. We discuss distributional features of such processes, explore inferential aspects and include an example of applications of the new processes to real-life data.Comment: 33 Pages, 14 Figures. arXiv admin note: text overlap with arXiv:2305.1302

Deep sequential modeling for recommendation

We propose a model which extends variational autoencoders by exploiting the rich information present in the past preference history. We introduce a recurrent version of the VAE, where instead of passing a subset of the whole history regardless of temporal dependencies, we rather pass the consumption sequence subset through a recurrent neural network. At each time-step of the RNN, the sequence is fed through a series of fully-connected layers, the output of which models the probability distribution of the most likely future preferences. We show that handling temporal information is crucial for improving the accuracy of recommendation

Synthesis, characterization and prediction of anticancer potentiality of some novel green nanoparticles by molecular docking and ADMET techniques

ABSTRACT. Anticancer potentiality of some newly synthesized Nano-Biginelli compounds with the help of enzyme extracted naturally from plants is reported. The biological synthesis of nanoparticles via nano biotechnology processes have a significant potential to enhance the production without the use of harsh, toxic, and expensive chemicals commonly used in conventional physical and chemical processes. The compounds have been characterized on the basis of UV, FTIR, XRD and SEM studies in order to depict the formation of nanoparticles. Using the combination of docking and ADMET techniques, we have tried to predict the anti-cancer potentiality as well as its area of target, i.e. cancer cell to trigger the anti-cancer reaction. Results indicate that the compound 1 (ethyl-6-methyl-2-oxo-4-(4-methoxyphenyl)-1,2,3,4-tetrahydropyrimidin-5-carboxylate) has possible virtual leads to design novel human Aurora B kinase inhibitor.               KEY WORDS: Nano biotechnology, Green chemistry, Enzymes, Drug research Bull. Chem. Soc. Ethiop. 2019, 33(3), 493-504.DOI: https://dx.doi.org/10.4314/bcse.v33i3.1

Toxicity in Neuronal Cells Caused by Cerebrospinal Fluid from Pneumococcaland Gram-Negative Meningitis

To identify neurotoxic factors in meningitis, a neuronal cell line (HN33.1) was exposed to cerebrospinal fluid (CSF) obtained from rabbits with pneumococcal meningitis or Escherichia coli meningitis or 2 h and 6 h after meningitis was induced by proinflammatory bacterial products (pneumococcal cell walls, endotoxin). CSF from all types of meningitis induced similar degrees of cytotoxicity. When a soluble tumor necrosis factor (TNF) receptor that completely blocked TNF-mediated toxicity at 10-7 M was used, all toxicity in meningitis caused by E. coli, endotoxin, or pneumococcal cell wall administration (2 h afterwards) was mediated by TNF. In contrast, CSF from animals with meningitis caused by live pneumococci or pneumococcal cell wall injection (6 h afterwards) retained cytotoxicity in the presence of the TNF receptor. Thus, in established pneumococcal meningitis, but not in the other forms of meningitis, TNF is not the only component toxic in this neuronal cell lin

Thermodynamic Structure of the Solar Corona: Tomographic Reconstructions and MHD Modeling

We carry out a study of the global three-dimensional (3D) structure of the electron density and temperature of the quiescent inner solar corona ($r<1.25 R_\odot$) by means of tomographic reconstructions and magnetohydrodynamic simulations. We use differential emission measure tomography (DEMT) and the Alfv\'en Wave Solar Model (AWSoM), in their latest versions. Two target rotations were selected from the solar minimum between solar cycles (SCs) 23 and 24 and the declining phase of SC 24. We report in quantitative detail on the 3D thermodynamic structure of the core and outer layers of the streamer belt, and of the high latitude coronal holes (CH), as revealed by the DEMT analysis. We report on the presence of two types of structures within the streamer belt, loops with temperature decreasing/increasing with height (dubbed down/up loops), as reported first in previous DEMT studies. We also estimate the heating energy flux required at the coronal base to keep these structures stable, found to be or order $10^5 erg\, cm^{-2} s^{-1}$, consistently with previous DEMT and spectroscopic studies. We discuss how these findings are consistent with coronal dissipation of Alfv\'en waves. We compare the 3D results of DEMT and AWSoM in distinct magnetic structures. We show that the agreement between the products of both techniques is the best so far, with an overall agreement $\lesssim 20\%$, depending on the target rotation and the specific coronal region. In its current implementation the ASWsoM model can not reproduce down loops though. Also, in the source region of the fast and slow components of the solar wind, the electron density of the AWSoM model increases with latitude, opposite to the trend observed in DEMT reconstructions

Arterio-enteric fistula in failed enteric-drained pancreas transplants: an impending danger

Enteric drainage is the preferred method of exocrine diversion in simultaneous kidney-pancreas transplantation. Because of improvements in immunosuppression, enteric drainage has become the preferred method of pancreas transplantation in general. Although associated with less potential complications than bladder-drained pancreas, potentially lethal arterio-enteric fistulas in the setting of nonfunctioning allografts represent a constant threat. We herein present a case report, a review of the literature, and a call for caution

Effects of Parvovirus B19 Infection in Renal Transplant Recipients: A Retrospective Review of Three Cases

Parvovirus B19 (PVB19) is a DNA virus which causes clinically relevant infection in renal transplant recipients (RTR) leading to significant morbidity. Manifestations include erythropoietin resistant anemia, proteinuria, and glomerulosclerosis in the allograft. Severe infection may require administration of intravenous immunoglobulin, reduction in immunosuppression and transfusions. The major challenge in managing and preventing the infection in RTR involves the act of balancing the decreased level of immunosuppression and the risk of rejection. The objective of this article is to understand the importance of PVB19 infection and its outcome in RTR. We reviewed the medical records of three RTR with confirmed PVB19 infection and recorded patient information including demographics, clinical and laboratory data, management, and outcome. The average time of occurrence of PVB19 infection as transplant was 8.6 weeks and they presented with symptomatic anemia. Elevated creatinine values were noted in two of them. Following treatment, anemia improved and creatinine values returned to baseline. One of them developed an early relapse and had to be treated once again similarly. We emphasize the importance of maintaining a high index of suspicion for PVB19 infection in patients with anemia in the posttransplant phase, especially in patients on higher doses of immunosuppressants. Early and proper treatment can prevent worsening clinical condition and possible effects on the allograft

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma.

Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth factor-β (TGF-β) superfamily, which has been found to play an integral role in the maintenance of stem cell homeostasis within multiple stem cell systems, as a mediator of stem-like cells in glioblastoma. We find that BMP and TGF-β signaling define divergent molecular and functional identities in glioblastoma, and mark relatively quiescent and proliferative GSCs, respectively. Treatment of GSCs with BMP inhibits cell proliferation, but does not abrogate their stem-ness, as measured by self-renewal and tumorigencity. Further, BMP pathway activation confers relative resistance to radiation and temozolomide chemotherapy. Our findings define a quiescent cancer stem cell population in glioblastoma that may be a cellular reservoir for tumor recurrence following cytotoxic therapy