328 research outputs found
Non-linear numerical simulations of magneto-acoustic wave propagation in small-scale flux tubes
We present results of non-linear, 2D, numerical simulations of
magneto-acoustic wave propagation in the photosphere and chromosphere of
small-scale flux tubes with internal structure. Waves with realistic periods of
three to five minutes are studied, after applying horizontal and vertical
oscillatory perturbations to the equilibrium model. Spurious reflections of
shock waves from the upper boundary are minimized thanks to a special boundary
condition. This has allowed us to increase the duration of the simulations and
to make it long enough to perform a statistical analysis of oscillations. The
simulations show that deep horizontal motions of the flux tube generate a slow
(magnetic) mode and a surface mode. These modes are efficiently transformed
into a slow (acoustic) mode in the vA < cS atmosphere. The slow (acoustic) mode
propagates vertically along the field lines, forms shocks and remains always
within the flux tube. It might deposit effectively the energy of the driver
into the chromosphere. When the driver oscillates with a high frequency, above
the cut-off, non-linear wave propagation occurs with the same dominant driver
period at all heights. At low frequencies, below the cut-off, the dominant
period of oscillations changes with height from that of the driver in the
photosphere to its first harmonic (half period) in the chromosphere. Depending
on the period and on the type of the driver, different shock patterns are
observed.Comment: 22 pages 6 color figures, submitted to Solar Physics, proceeding of
SOHO 19/ GONG 2007 meeting, Melbourne, Australi
Interoperability framework for supporting information-based assistance in the factory
The aim of this paper is to propose new interoperability solution, based on Info-Engine framework and web services technology to support data exchange and extraction from PLM system, specially the Windchill tool. This solution will be implemented as a connector module of more generic framework, named Digital Factory Assistant (DFA). The DFA framework aims to provide factory workers by a set of knowledge and information based decision support to improve their activity performance
Laparoscopic umbilical hernia repair in the presence of extensive paraumbilical collateral veins: A case report
A patient with an umbilical hernia presenting with collateral veins in the abdominal wall and umbilicus is a case that every hernia surgeon has to deal with occasionally. Several underlying diseases have been described to provoke collateral veins in the abdominal wall. However, the treatment strategy should be uniform. We herein report a case of a successful laparoscopic umbilical hernia repair in a patient with collateral veins in the abdominal wall and umbilicus. A 63-year-old man was referred to the surgical outpatient clinic with a large symptomatic umbilical hernia and collateral veins in the abdominal wall, secondary to an occlusion of both common iliac veins. Because of collateral veins in the umbilicus and the size of the hernial defect, he was offered laparoscopic hernia repair without compromising these veins. Because of the extensive abdominal wall collaterals, duplex sonography vein mapping was performed preoperatively to mark a safe collateral-free area for trocar introduction. The defect was repaired by mesh prosthesis
Magneto-Acoustic Wave Oscillations in Solar Spicules
Some observations suggest that solar spicules show small amplitude and high
frequency oscillations of magneto-acoustic waves, which arise from photospheric
granular forcing. We apply the method of MHD seismology to determine the period
of kink waves. For this purposes, the oscillations of a magnetic cylinder
embedded in a field-free environment is investigated. Finally, diagnostic
diagrams displaying the oscillatory period in terms of some equilibrium
parameters are provided to allow a comparison between theoretical results and
those coming from observations.Comment: 10 pages, 4 fig
Fingolimod and tumor-infiltrating lymphocytes in checkpoint-inhibitor treated cancer patients.
Immune checkpoint inhibitors (ICIs) are emerging as the new standard of care for treating various metastatic cancers. It is known that effective anti-tumor immune responses are associated with a stronger presence of tumor-infiltrating lymphocytes (TILs) in solid tumor tissue. Cancer patients with relapsing-remitting multiple sclerosis (RRMS) are often under continuous treatment with fingolimod, an immune-modulating drug that inhibits lymphocyte egress from secondary lymphatic organs. Little is known about the effect of fingolimod on ICI cancer therapy, as fingolimod may limit the number of TILs. Here we present three patients with RRMS, who developed various cancers during fingolimod treatment. Histology of all tumors consistently showed low numbers of TILs. A second biopsy taken from one of the tumors, a melanoma, revealed a significant increase of TILs after stopping fingolimod and starting pembrolizumab, indicating a surge in the number and re-invigoration of T cells. Our study suggests that fingolimod limits the number of TILs in solid tumors and may, thus, inhibit anti-cancer immune responses
Pharmaceutical Policy Reforms to Regulate Drug Prices in Asia Pacific Region: The Case of Australia, China, India, Malaysia, New Zealand, and South Korea.
Medicine price directly affects affordability and access to medicines particularly in countries where a major portion of pharmaceutical spending is through out-of-pocket payment, such as in the Asia Pacific region. We have undertaken a detailed appraisal of the pharmaceutical policy reforms to regulate drug prices in 3 developed (Australia, New Zealand, and South Korea) and 3 emerging (China, India, and Malaysia) economies of the Asia Pacific region. Despite continuous efforts by the authorities in adopting a wide range of reformatory pharmaceutical pricing policies to ensure affordability of medicines, these policies may not be optimal where drug prices were not lowered as expected (eg, in Korea). On the contrary, considerable price reductions of various pharmaceuticals have been observed in New Zealand and India because of the reform in pharmaceutical pricing policy. This review of pharmaceutical pricing reforms reinforces the need for constant monitoring by policy makers in Asia Pacific countries to regulate drug prices and to undertake reform in pharmaceutical pricing policies when necessary to ensure affordability and access to medicines
Optical excitations in a one-dimensional Mott insulator
The density-matrix renormalization-group (DMRG) method is used to investigate
optical excitations in the Mott insulating phase of a one-dimensional extended
Hubbard model. The linear optical conductivity is calculated using the
dynamical DMRG method and the nature of the lowest optically excited states is
investigated using a symmetrized DMRG approach. The numerical calculations
agree perfectly with field-theoretical predictions for a small Mott gap and
analytical results for a large Mott gap obtained with a strong-coupling
analysis. Is is shown that four types of optical excitations exist in this Mott
insulator: pairs of unbound charge excitations, excitons, excitonic strings,
and charge-density-wave (CDW) droplets. Each type of excitations dominates the
low-energy optical spectrum in some region of the interaction parameter space
and corresponds to distinct spectral features: a continuum starting at the Mott
gap (unbound charge excitations), a single peak or several isolated peaks below
the Mott gap (excitons and excitonic strings, respectively), and a continuum
below the Mott gap (CDW droplets).Comment: 12 pages (REVTEX 4), 12 figures (in 14 eps files), 1 tabl
Oscillations and waves in solar spicules
Since their discovery, spicules have attracted increased attention as energy/mass bridges between the dense and dynamic photosphere and the tenuous hot solar corona. Mechanical energy of photospheric random and coherent motions can be guided by magnetic field lines, spanning from the interior to the upper parts of the solar atmosphere, in the form of waves and oscillations. Since spicules are one of the most pronounced features of the chromosphere, the energy transport they participate in can be traced by the observations of their oscillatory motions. Oscillations in spicules have been observed for a long time. However the recent high-resolutions and high-cadence space and ground based facilities with superb spatial, temporal and spectral capacities brought new aspects in the research of spicule dynamics. Here we review the progress made in imaging and spectroscopic observations of waves and oscillations in spicules. The observations are accompanied by a discussion on theoretical modelling and interpretations of these oscillations. Finally, we embark on the recent developments made on the presence and role of Alfven and kink waves in spicules. We also address the extensive debate made on the Alfven versus kink waves in the context of the explanation of the observed transverse oscillations of spicule axes
Numerical Simulations of Magnetoacoustic-Gravity Waves in the Solar Atmosphere
We investigate the excitation of magnetoacoustic-gravity waves generated from
localized pulses in the gas pressure as well as in vertical component of
velocity. These pulses are initially launched at the top of the solar
photosphere that is permeated by a weak magnetic field. We investigate three
different configurations of the background magnetic field lines: horizontal,
vertical and oblique to the gravitational force. We numerically model
magnetoacoustic-gravity waves by implementing a realistic (VAL-C) model of
solar temperature. We solve two-dimensional ideal magnetohydrodynamic equations
numerically with the use of the FLASH code to simulate the dynamics of the
lower solar atmosphere. The initial pulses result in shocks at higher
altitudes. Our numerical simulations reveal that a small-amplitude initial
pulse can produce magnetoacoustic-gravity waves, which are later reflected from
the transition region due to the large temperature gradient. The atmospheric
cavities in the lower solar atmosphere are found to be the ideal places that
may act as a resonator for various oscillations, including their trapping and
leakage into the higher atmosphere. Our numerical simulations successfully
model the excitation of such wave modes, their reflection and trapping, as well
as the associated plasma dynamics
Magnetic Field Structures in a Facular Region Observed by THEMIS and Hinode
The main objective of this paper is to build and compare vector magnetic maps
obtained by two spectral polarimeters, i.e. THEMIS/MTR and Hinode SOT/SP, using
two inversion codes (UNNOFIT and MELANIE) based on the Milne-Eddington solar
atmosphere model. To this end, we used observations of a facular region within
active region NOAA 10996 on 23 May 2008, and found consistent results
concerning the field strength, azimuth and inclination distributions. Because
SOT/SP is free from the seeing effect and has better spatial resolution, we
were able to resolve small magnetic polarities with sizes of 1" to 2", and we
could detect strong horizontal magnetic fields, which converge or diverge in
negative or positive facular polarities. These findings support models which
suggest the existence of small vertical flux tube bundles in faculae. A new
method is proposed to get the relative formation heights of the multi-lines
observed by MTR assuming the validity of a flux tube model for the faculae. We
found that the Fe 1 6302.5 \AA line forms at a greater atmospheric height than
the Fe 1 5250.2 \AA line.Comment: 20 pages, 9 figures, 3 tables, accepted for publication in Solar
Physic
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