ALOE VERA POWDER BASED MATRIX TABLET FOR ORAL CONTROLLED DELIVERY OF HIGHLY SOLUBLE DRUG

This study mainly aimed for oral control delivery system of highly water soluble drug using aloe vera powder as a carrier for matrix tablet. Ascorbic acid is taken as a model drug for its high solubility. Different concentrations such as 30 %, 40 % and 50 % of matrix tablets of Aloe Vera powder are made by wet granulation technique using starch paste as a binder. The formulated granules were further subjected to Quality control test such as Angle of repose (º), Bulk Density, Carr's Index and Hausner ratio. These matrix tablets are then subjected to in vitro drug release using USP dissolution apparatus. The amount of ascorbic acid released from the matrix is estimated by using UV spectrometer and this result is compared with marketed ascorbic acid tablets. Formulation containing 40 % matrix was found to be good as compared to other two formulations and shows better controlled release of drug