GPCR-OKB: the G protein coupled receptor oligomer knowledge base

Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers

Identification and reconstruction of low-energy electrons in the ProtoDUNE-SP detector

International audienceMeasurements of electrons from νe interactions are crucial for the Deep Underground Neutrino Experiment (DUNE) neutrino oscillation program, as well as searches for physics beyond the standard model, supernova neutrino detection, and solar neutrino measurements. This article describes the selection and reconstruction of low-energy (Michel) electrons in the ProtoDUNE-SP detector. ProtoDUNE-SP is one of the prototypes for the DUNE far detector, built and operated at CERN as a charged particle test beam experiment. A sample of low-energy electrons produced by the decay of cosmic muons is selected with a purity of 95%. This sample is used to calibrate the low-energy electron energy scale with two techniques. An electron energy calibration based on a cosmic ray muon sample uses calibration constants derived from measured and simulated cosmic ray muon events. Another calibration technique makes use of the theoretically well-understood Michel electron energy spectrum to convert reconstructed charge to electron energy. In addition, the effects of detector response to low-energy electron energy scale and its resolution including readout electronics threshold effects are quantified. Finally, the relation between the theoretical and reconstructed low-energy electron energy spectrum is derived and the energy resolution is characterized. The low-energy electron selection presented here accounts for about 75% of the total electron deposited energy. After the addition of missing energy using a Monte Carlo simulation, the energy resolution improves from about 40% to 25% at 50 MeV. These results are used to validate the expected capabilities of the DUNE far detector to reconstruct low-energy electrons

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Studies on Phytochemicals, Minerals, Antioxidants and Efficacy of Crude Extracts of Therapeutic Herbal Potentilla reptans L. on Certain Pathogenic Causal Agents

The crude extract of indigenous herbal Potentilla reptans L. habitat wild belonging to Rosaceae family, has been explored in search of therapeutic compounds that amalgamate as associative phytochemical and phyto mineral constituents. A number of novel bioactive organic compounds viz. antioxidant (30.8 μg/mL), saponin (30 mg/g), flavonoid (10.39 mg/g), alkaloid (30 mg/g), phenol (4.33 mg/g,) tannin (30.74 mg/g) and minerals like magnesium (4.55 mg/g), iron (1.12 mg/g), sulfur (1.85 mg/g), potassium (1.26 mg/g), manganese (0.10 mg/g), calcium (5.16 mg/g), phosphorous (0.14 mg/g), zinc (0.12 mg/g) and copper (0.06 mg/g), an indispensable sources of precious chemo-diversity, the only means for survivability of species forever on earth have depicted. In an antimicrobial test with crude extracts, a strong positive effect against Staphylococcus aureus in bacteria and Candida albicans, Microsporum gypseum in fungi by all extracts of MeOH, EtOAc and CHCl3 was authenticated to the aged old traditional health care system of herbals and novel to unique in home remedy prescriptions.</jats:p

REDESCRIPTION OF Minervarya nicobariensis (STOLIZKA, 1870) (AMPHIBIA: DICROGLOSSIDAE) WITH A NEOTYPE DESIGNATION

The poorly-known, insular endemic frog species, Minervarya nicobariensis (Stoliczka, 1870) is re-described based on new material from the Nicobar Archipelago. A neotype is designated as its holotype had been lost. Novel data on biology, ecology, distribution and natural history of this poorly known species are provided. Breeding biology and larval morphology are described in detail. Potential threats to the species are discussed and an assessment of its conservation status is attempted.</jats:p

Ultrastructures of silver nanoparticles biosynthesized using endophytic fungi

AbstractThree endophytic fungi Aspergillus tamarii PFL2, Aspergillus niger PFR6 and Penicllium ochrochloron PFR8 isolated from an ethno-medicinal plant Potentilla fulgens L. were used for the biosynthesis of silver nanoparticles. Scanning and transmission electron microscopic analysis were performed to study the structural morphology of the biosynthesized silver nanoparticles. The electron microscopy study revealed the formation of spherical nanosized silver particles with different sizes. The nanoparticles synthesized using the fungus A. tamarii PFL2 was found to have the smallest average particle size (3.5±3nm) as compared to the nanoparticles biosynthesized using other two fungi A. niger PFR6 and P. ochrochloron PFR8 which produced average particle sizes of 8.7±6nm and 7.7±4.3nm, respectively. The energy dispersive X-ray spectroscopy (EDS) technique in conjunction with scanning electron microscopy was used for the elemental analysis of the nanoparticles. The selected area diffraction pattern recorded from single particle in the aggregates of nanoparticles revealed that the silver particles are crystalline in nature

Effect of Calcium Nitrate and Potassium Nitrate priming on seed germination and seedling vigour of papaya (Carica papaya L.).

Not AvailableThe effect of seed priming with calcium nitrate Ca(NO3)2 and potassium nitrate (KNO3) on germination and seedling vigour were studied in papaya varieties. Open pollinated local (gauty) papaya seeds were soaked in Ca(NO3)2and KNO3 solutions (10000 ppm,15000 ppm and 20000 ppm) up to 24 hours and germination percentage and seedling characteristics were recorded. The least number of days taken for seed germination (4.33 days), the highest germination percentage (82.56 %), the highest shoot length (14.31 cm) and the highest fresh biomass (1.36 g) and dry biomass (0.174 g) were recorded in 10000 ppm Ca(NO3)2 treatment. Further, seeds of papaya varieties viz., Arka Surya, Arka Prabhat and Madhu bindhu were treated with 5000 ppm, 10000 ppm and 15000 ppm Ca(NO3)2 and observed that Arka Prabhat seeds treated with 10000 ppm Ca(NO3)2 had taken the least number of days for germination (4.75 days) and also the highest shoot length (25.2 cm). The results of the experiment proved the significant effect of calcium ions over potassium ions on papaya seed germination and seedling vigour.Not Availabl

Hubungan Tingkat Pendidikan Ibu, Tingkat Pendapatan Orang Tua Dan Tingkat Pengetahuan Gizi Anak Dengan Status Gizi Siswa-Siswi Sekolah Menengah Pertama Al-Hikmah Petukangan Selatan.

Status gizi merupakan salah satu faktor yang sangat berpengaruh pada kualitas sumber daya manusia karena mempengaruhi kecerdasan, produktivitas, dan kreativitas. Dalam upaya peningkatan status gizi pada hakekatnya harus dimulai sedini mungkin pada usia anak remaja. Pada usia ini harus diperhatikan untuk menunjang produksi fisik otak yang merupakan syarat agar anak mempunyai kecerdasan tinggi. Permasalahan yang dikaji dalam penelitian ini adalah hubungan tingkat pendidikan ibu, tingkat pendapatan orang tua dan tingkat pengetahuan gizi anak dengan status gizi. Penelitian ini menggunakan desain penelitian cross sectional dengan tujuan untuk mengetahui hubungan dua variabel, variabel terikat (Dependen) dan variabel bebas (Independen) pada waktu yang sama. Teknik sampling yang digunakan adalah Stratified Random Sampling. Hasil analisis bivariat Dari 4 variabel terdapat 2 variabel yang memiliki hubungan yang bermakna yaitu hubungan jenis kelamin dengan status gizi dengan Pvalue = 0,005, dan hubungan tingkat pengetahuan gizi anak dengan status gizi dengan Pvalue = 0,002. Sedangkan 2 variabel lainnya tidak ada hubungan yang bermakna, variabel tersebut antara lain yaitu Hubungan tingkat pendidikan ibu dengan status gizi dengan Pvalue = 1,121 dan Hubungan tingkat pendapatan orang tua dengan status gizi dengan Pvalue = 2,760. Berdasarkan hasil penelitian disarankan perlu diadakan penelitian selanjutnya mengenai Status Gizi pada remaja untuk memberikan informasi kepada anak remaja, serta memberikan pengetahuan mengenai status gizi melalui buku-buku bacaan dan peran UKS untuk mensosialisasikan tentang gaya hidup sehat